2010
Psychosocial outcome and psychiatric comorbidity in older adolescents with Tourette syndrome: controlled study
Gorman DA, Thompson N, Plessen KJ, Robertson MM, Leckman JF, Peterson BS. Psychosocial outcome and psychiatric comorbidity in older adolescents with Tourette syndrome: controlled study. The British Journal Of Psychiatry 2010, 197: 36-44. PMID: 20592431, PMCID: PMC2894981, DOI: 10.1192/bjp.bp.109.071050.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderGlobal Assessment Scale scoresTourette syndromePsychosocial outcomesComorbidity ratesChildren's Global Assessment Scale scoresPsychosocial functioningImprovement of ticsLifetime psychiatric disordersLower Children's Global Assessment Scale (CGAS) scoresAssessment Scale scoresAge 18 yearsYears of ageHigh comorbidity ratesOlder adolescentsLifetime comorbidity ratesLower CGAS scoresPoor psychosocial outcomesComorbidity outcomesPsychiatric comorbidityMajor depressionCGAS scoresPsychiatric disordersTic severityObsessive-compulsive disorder symptoms
2009
Clinical course of Tourette syndrome
Bloch MH, Leckman JF. Clinical course of Tourette syndrome. Journal Of Psychosomatic Research 2009, 67: 497-501. PMID: 19913654, PMCID: PMC3974606, DOI: 10.1016/j.jpsychores.2009.09.002.Peer-Reviewed Original ResearchConceptsTourette syndromeComorbid conditionsObsessive-compulsive disorderClinical courseLong-term clinical courseChildhood-onset neuropsychiatric disorderEarly adulthoodLong-term outcomesAttention deficit disorderTic symptomsDepressive disorderTic disordersVocal ticsGeneral populationNeuropsychiatric disordersLiterature searchRelevant articlesDisordersSyndromeChildrenAdulthood outcomesOne-thirdSymptomsTraditional literature searchThree-quartersDimensional predictors of response to SRI pharmacotherapy in obsessive–compulsive disorder
Landeros-Weisenberger A, Bloch MH, Kelmendi B, Wegner R, Nudel J, Dombrowski P, Pittenger C, Krystal JH, Goodman WK, Leckman JF, Coric V. Dimensional predictors of response to SRI pharmacotherapy in obsessive–compulsive disorder. Journal Of Affective Disorders 2009, 121: 175-179. PMID: 19577308, PMCID: PMC3974618, DOI: 10.1016/j.jad.2009.06.010.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSRI responseSymptom dimensionsOpen-label continuation phaseClinical Global Improvement ScaleGlobal Improvement ScaleCentral serotonin systemInitial positive responseYale-Brown ObsessiveContinuation phaseMinor symptomsOrdinal logistic regressionClinical trialsSerotonin systemTreatment responseSame patientImprovement ScaleSRI treatmentPatientsSignificant associationLogistic regressionCompulsive ScaleOCD patientsOCD subjectsSymptoms
2005
Caudate volumes in childhood predict symptom severity in adults with Tourette syndrome
Bloch MH, Leckman JF, Zhu H, Peterson BS. Caudate volumes in childhood predict symptom severity in adults with Tourette syndrome. Neurology 2005, 65: 1253-1258. PMID: 16247053, PMCID: PMC2367161, DOI: 10.1212/01.wnl.0000180957.98702.69.Peer-Reviewed Original ResearchConceptsSeverity of ticsBasal ganglia volumesCaudate nucleus volumeTourette syndromeObsessive-compulsive symptomsGanglia volumesEarly adulthoodObsessive-compulsive disorderTic symptomsCaudate nucleusCaudate volumeCross-sectional imaging studiesThalamo-cortical circuitsNucleus volumeSeverity of symptomsAge 16 yearsProspective longitudinal studyAge 14 yearsClinical statusClinical assessmentClinical measuresMorphologic disturbancesMRI scansSymptomsImaging studies
2000
Sensory phenomena in obsessive-compulsive disorder and Tourette's disorder.
Miguel EC, do Rosário-Campos MC, Prado HS, do Valle R, Rauch SL, Coffey BJ, Baer L, Savage CR, O'Sullivan RL, Jenike MA, Leckman JF. Sensory phenomena in obsessive-compulsive disorder and Tourette's disorder. The Journal Of Clinical Psychiatry 2000, 61: 150-6; quiz 157. PMID: 10732667, DOI: 10.4088/jcp.v61n0213.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderTourette's disorderDisorder groupTic-related obsessive-compulsive disorderSensory phenomenaDisorder diagnosisMental sensationsDisorder spectrumAlone groupClinical indicesAdult outpatientsBody sensationPatientsBodily sensationsHeterogeneous disorderPatients' performanceDisordersPhenotypic featuresSensationSemistructured interviewsPresent studyRepetitive behaviorsRecent studiesGroupInner tension