2014
Transcriptome Analysis of the Human Striatum in Tourette Syndrome
Lennington JB, Coppola G, Kataoka-Sasaki Y, Fernandez TV, Palejev D, Li Y, Huttner A, Pletikos M, Sestan N, Leckman JF, Vaccarino FM. Transcriptome Analysis of the Human Striatum in Tourette Syndrome. Biological Psychiatry 2014, 79: 372-382. PMID: 25199956, PMCID: PMC4305353, DOI: 10.1016/j.biopsych.2014.07.018.Peer-Reviewed Original ResearchConceptsCopy number variantsGenome-wide association studiesGene coexpression modulesNumber variantsGene network analysisCommon genetic variantsCoexpression modulesUpregulated genesMetabolism modulesImmune-related genesNetwork analysisAssociation studiesDifferential expressionUpregulated modulesGenetic variantsGenesPatient's striatumTS individualsTranscriptomeVariantsMetabolic alterationsSame regionGamma-aminobutyric acidergic interneuronsTranscriptsRNA
1991
Detection of homeobox genes in development and evolution.
Murtha MT, Leckman JF, Ruddle FH. Detection of homeobox genes in development and evolution. Proceedings Of The National Academy Of Sciences Of The United States Of America 1991, 88: 10711-10715. PMID: 1720547, PMCID: PMC53000, DOI: 10.1073/pnas.88.23.10711.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBiological EvolutionCiona intestinalisCodonDipteraDrosophilaEmbryo, MammalianEmbryo, NonmammalianGenes, HomeoboxMaleMiceMolecular Sequence DataOligodeoxyribonucleotidesPolymerase Chain ReactionRestriction MappingRNASequence Homology, Nucleic AcidTelencephalonConceptsHomeobox genesHomeobox sequencesDNA-binding regulatory proteinsDiverse metazoan speciesSurvey of sequencesMouse genomic DNAImportant model systemPopulations of DNAMetazoan speciesAncient roleMetazoan evolutionPolymerase chain reactionGenomic organizationDrosophila H2.0Regulatory proteinsHlx geneGenomic DNAStudy of developmentMouse telencephalonNovel sequencesGenesOligonucleotide primersHomeodomainModel systemRNA