2017
The Child Behavior Checklist—Obsessive-Compulsive Subscale Detects Severe Psychopathology and Behavioral Problems Among School-Aged Children
Saad LO, do Rosario MC, Cesar RC, Batistuzzo MC, Hoexter MQ, Manfro GG, Shavitt RG, Leckman JF, Miguel EC, Alvarenga PG. The Child Behavior Checklist—Obsessive-Compulsive Subscale Detects Severe Psychopathology and Behavioral Problems Among School-Aged Children. Journal Of Child And Adolescent Psychopharmacology 2017, 27: 342-348. PMID: 28151703, PMCID: PMC5439443, DOI: 10.1089/cap.2016.0125.Peer-Reviewed Original ResearchConceptsObsessive-compulsive symptomsPsychiatric comorbidityPredictive valueBehavioral problemsDSM-IV psychiatric diagnosesPresence of OCSGroup of patientsHigh-risk cohortSignificant obsessive-compulsive symptomsNegative predictive valuePositive predictive valueHigh rateSeverity of OCSRisk cohortSchool-Aged ChildrenDepressive disorderFunctional impairmentPsychiatric diagnosisChild Behavior ChecklistComorbiditiesSevere psychopathologyBeing AssessmentScreening toolPediatric OCDAnxiety disorders
2015
Obsessive–compulsive symptoms are associated with psychiatric comorbidities, behavioral and clinical problems: a population-based study of Brazilian school children
Alvarenga PG, do Rosario MC, Cesar RC, Manfro GG, Moriyama TS, Bloch MH, Shavitt RG, Hoexter MQ, Coughlin CG, Leckman JF, Miguel EC. Obsessive–compulsive symptoms are associated with psychiatric comorbidities, behavioral and clinical problems: a population-based study of Brazilian school children. European Child & Adolescent Psychiatry 2015, 25: 175-182. PMID: 26015374, DOI: 10.1007/s00787-015-0723-3.Peer-Reviewed Original ResearchConceptsFamily History ScreenObsessive-compulsive disorderObsessive-compulsive symptomsSchool-aged childrenChild Behavior ChecklistUnaffected controlsPediatric-onset obsessive-compulsive disorderPresence of OCSPopulation-based studyComorbid psychiatric disordersMajor depressive disorderWell-Being AssessmentOCD groupBrazilian school childrenGroup of childrenPsychiatric comorbidityDepressive disorderClinical impactFunctional impairmentPsychiatric disordersClinical problemOCS groupDiagnostic groupsSignificant socio-demographic differencesSocio-demographic differencesObsessive-compulsive symptom dimensions in a population-based, cross-sectional sample of school-aged children
Alvarenga PG, Cesar RC, Leckman JF, Moriyama TS, Torres AR, Bloch MH, Coughlin CG, Hoexter MQ, Manfro GG, Polanczyk GV, Miguel EC, do Rosario MC. Obsessive-compulsive symptom dimensions in a population-based, cross-sectional sample of school-aged children. Journal Of Psychiatric Research 2015, 62: 108-114. PMID: 25702286, DOI: 10.1016/j.jpsychires.2015.01.018.Peer-Reviewed Original ResearchConceptsSchool-aged childrenPsychiatric symptomsFamily History ScreenAdditional clinical factorsSymptom dimensionsCommunity-based sampleObsessive-compulsive symptom dimensionsClinical factorsObsessive-compulsive disorderPsychiatric comorbidityClinical impairmentSchool impairmentCross-sectional sampleAge 6Clinical samplesFamilial aggregationBiological mothersChildrenBiological relativesSymptomsPrevalenceAge distributionImpairmentNon-clinical samplePresent study
2012
Trajectory in obsessive-compulsive disorder comorbidities
de Mathis MA, Diniz JB, Hounie AG, Shavitt RG, Fossaluza V, Ferrão Y, Leckman JF, de Bragança Pereira C, do Rosario MC, Miguel EC. Trajectory in obsessive-compulsive disorder comorbidities. European Neuropsychopharmacology 2012, 23: 594-601. PMID: 22921470, DOI: 10.1016/j.euroneuro.2012.08.006.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderHigher lifetime frequencyOCD patientsFirst diagnosisTic disordersSeparation anxiety disorderLifetime frequencyObsessive-compulsive disorder (OCD) comorbidityAnxiety disordersOnset of OCDDistribution of comorbiditiesSpecific comorbid diagnosesLifetime psychiatric diagnosesPost-traumatic stress disorderFirst comorbiditySymptom onsetClinical courseClinical presentationPsychiatric comorbidityDisorder comorbidityOCD courseBeck AnxietyComorbid disordersPsychiatric disordersComorbidities
2010
Psychosocial outcome and psychiatric comorbidity in older adolescents with Tourette syndrome: controlled study
Gorman DA, Thompson N, Plessen KJ, Robertson MM, Leckman JF, Peterson BS. Psychosocial outcome and psychiatric comorbidity in older adolescents with Tourette syndrome: controlled study. The British Journal Of Psychiatry 2010, 197: 36-44. PMID: 20592431, PMCID: PMC2894981, DOI: 10.1192/bjp.bp.109.071050.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderGlobal Assessment Scale scoresTourette syndromePsychosocial outcomesComorbidity ratesChildren's Global Assessment Scale scoresPsychosocial functioningImprovement of ticsLifetime psychiatric disordersLower Children's Global Assessment Scale (CGAS) scoresAssessment Scale scoresAge 18 yearsYears of ageHigh comorbidity ratesOlder adolescentsLifetime comorbidity ratesLower CGAS scoresPoor psychosocial outcomesComorbidity outcomesPsychiatric comorbidityMajor depressionCGAS scoresPsychiatric disordersTic severityObsessive-compulsive disorder symptoms