2022
Neuroimmunoendocrinology of Tourette Syndrome
Martino D, Johnson I, Escobar A, Leckman J. Neuroimmunoendocrinology of Tourette Syndrome. 2022, 257-276. DOI: 10.1093/med/9780197543214.003.0016.Peer-Reviewed Original ResearchTourette syndromeImmune-modulatory interventionsImmune competent cellsGeneration of ticsCortico-subcortical circuitsNormal brain developmentNeuroimmune interactionsKey molecular pathwaysGut dysbiosisAllergic illnessHigh riskImmune pathwaysPostnatal lifeTherapeutic interventionsImmune primingImmune systemRelated disordersNeural circuitsBrain developmentNeurodevelopmental disordersDisordersMolecular pathwaysSyndromeDate summaryMolecular mechanisms
2014
Tourette syndrome deep brain stimulation: A review and updated recommendations
Schrock LE, Mink JW, Woods DW, Porta M, Servello D, Visser‐Vandewalle V, Silburn PA, Foltynie T, Walker HC, Shahed‐Jimenez J, Savica R, Klassen BT, Machado AG, Foote KD, Zhang J, Hu W, Ackermans L, Temel Y, Mari Z, Changizi BK, Lozano A, Auyeung M, Kaido T, Agid Y, Welter ML, Khandhar SM, Mogilner AY, Pourfar MH, Walter BL, Juncos JL, Gross RE, Kuhn J, Leckman JF, Neimat JA, Okun MS, Group T. Tourette syndrome deep brain stimulation: A review and updated recommendations. Movement Disorders 2014, 30: 448-471. PMID: 25476818, DOI: 10.1002/mds.26094.Peer-Reviewed Original ResearchConceptsDeep brain stimulationTourette syndromeBrain stimulationBehavioral treatment trialsFifth Edition diagnosisPostoperative outcome measuresOptimal surgical approachMultidisciplinary team approachTourette syndrome patientsMultiple brain targetsYears of ageLocal ethics committeeInstitutional review boardDBS centersMedication refractoryUrgent indicationsSevere motorSurgical approachTreatment trialsBrain targetsEdition diagnosisVocal ticsSyndrome patientsOutcome measuresHigh risk
2010
Oxytocin and the Development of Parenting in Humans
Gordon I, Zagoory-Sharon O, Leckman JF, Feldman R. Oxytocin and the Development of Parenting in Humans. Biological Psychiatry 2010, 68: 377-382. PMID: 20359699, PMCID: PMC3943240, DOI: 10.1016/j.biopsych.2010.02.005.Peer-Reviewed Original Research
2004
Age Effects on Antidepressant-Induced Manic Conversion
Martin A, Young C, Leckman JF, Mukonoweshuro C, Rosenheck R, Leslie D. Age Effects on Antidepressant-Induced Manic Conversion. JAMA Pediatrics 2004, 158: 773-780. PMID: 15289250, DOI: 10.1001/archpedi.158.8.773.Peer-Reviewed Original ResearchConceptsManic conversionAntidepressant classesPatient ageTime-dependent Cox proportional hazards modelsSelective serotonin reuptake inhibitorsCox proportional hazards modelNonbipolar mood disorderSerotonin reuptake inhibitorsProportional hazards modelRisk of conversionAdministrative national databaseEffect of agePharmacy claimsReuptake inhibitorsAntidepressant exposureDrug therapyTricyclic antidepressantsPeripubertal childrenAge effectsBipolar illnessMood disordersHigh riskMental health usersAntidepressant categoryHazards model
2002
Development and natural history of mood disorders
Costello EJ, Pine DS, Hammen C, March JS, Plotsky PM, Weissman MM, Biederman J, Goldsmith HH, Kaufman J, Lewinsohn PM, Hellander M, Hoagwood K, Koretz DS, Nelson CA, Leckman JF. Development and natural history of mood disorders. Biological Psychiatry 2002, 52: 529-542. PMID: 12361667, DOI: 10.1016/s0006-3223(02)01372-0.Peer-Reviewed Original ResearchConceptsMood disordersMood disorders researchPediatric-onset bipolar disorderBipolar disorderUnipolar depressionNatural historySpecific risk factorsModel of pathogenesisPrecursor of depressionPsychotropic medicationsRisk infantsRisk factorsSuccessful treatmentHigh riskMultidisciplinary workgroupChildhood anxiety disordersJuvenile depressionDisorder researchEarly onsetProtective factorsAnxiety disordersPanel of expertsMental healthDisordersDepression
2000
The Psychiatric Symptoms of Rheumatic Fever
Mercadante MT, Busatto GF, Lombroso PJ, Prado L, Rosário-Campos MC, do Valle R, Marques-Dias MJ, Kiss MH, Leckman JF, Miguel EC. The Psychiatric Symptoms of Rheumatic Fever. American Journal Of Psychiatry 2000, 157: 2036-2038. PMID: 11097972, DOI: 10.1176/appi.ajp.157.12.2036.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderRheumatic feverSydenham's choreaTic disordersHigh riskComparison groupFever groupMajor depressive disorderDeficit hyperactivity disorderObsessive-compulsive disorderDepressive disorderRisk factorsPsychiatric symptomsPsychiatric disordersChoreaFeverNeuropsychiatric disordersObsessive-compulsive symptomsRating ScaleHyperactivity disorderSymptomsDisordersADHD symptomsChildrenSemistructured interviews
1995
A family study of obsessive-compulsive disorder
Pauls DL, Alsobrook JP, Goodman W, Rasmussen S, Leckman JF. A family study of obsessive-compulsive disorder. American Journal Of Psychiatry 1995, 152: 76-84. PMID: 7802125, DOI: 10.1176/ajp.152.1.76.Peer-Reviewed Original ResearchConceptsFirst-degree relativesObsessive-compulsive disorderComparison subjectsSubthreshold obsessive-compulsive disorderAvailable first-degree relativesGilles de la Tourette's syndromeRelatives of probandsLa Tourette's syndromeFamily studiesBest-estimate diagnosesRate of ticsTic disordersFamily historyHigh riskTourette syndromeChronic ticsFemale probandsEarly onsetFamilial typeDisordersUnaffected subjectsProbandsSyndromeStructured interviewsSubjects