1989
Plasma debrisoquin levels in the assessment of reduction of plasma homovanillic acid. The debrisoquin method.
Riddle MA, Jatlow PI, Anderson GM, Cho SC, Hardin MT, Cohen DJ, Leckman JF. Plasma debrisoquin levels in the assessment of reduction of plasma homovanillic acid. The debrisoquin method. Neuropsychopharmacology 1989, 2: 123-9. PMID: 2742727, DOI: 10.1016/0893-133x(89)90015-8.Peer-Reviewed Original ResearchConceptsCentral nervous systemPeripheral HVA productionDebrisoquin sulfatePHVA levelsHomovanillic acidPlasma homovanillic acidCerebrospinal fluid samplesAssessment of reductionDopamine metabolismPlasma concentrationsNervous systemFluid samplesSubstantial inhibitionHVACN metabolismDoseComplete inhibitionDopamineSubjectsInhibitionMetabolismDebrisoquinLevelsPHVA
1986
Assessment or central dopaminergic function using plasma-free homovanillic acid after debrisoquin administration
Riddle MA, Leckman JF, Cohen DJ, Anderson M, Ort SI, Caruso KA, Shaywitz BA. Assessment or central dopaminergic function using plasma-free homovanillic acid after debrisoquin administration. Journal Of Neural Transmission 1986, 67: 31-43. PMID: 3465864, DOI: 10.1007/bf01243357.Peer-Reviewed Original ResearchConceptsCentral dopaminergic functionDopaminergic functionHomovanillic acidDopamine metabolite homovanillic acidCentral DA activityChronic oral administrationPlasma-free homovanillic acidSingle oral doseBlood-brain barrierMetabolite homovanillic acidBehavioral side effectsOral dosePeripheral metabolismDA activityOral administrationSide effectsDebrisoquinAdministration methodsMarked reductionHVAAdministrationPeripheral formationAdultsValid techniqueChildren