2015
Oxytocin-augmented labor and risk for autism in males
Weisman O, Agerbo E, Carter CS, Harris JC, Uldbjerg N, Henriksen TB, Thygesen M, Mortensen PB, Leckman JF, Dalsgaard S. Oxytocin-augmented labor and risk for autism in males. Behavioural Brain Research 2015, 284: 207-212. PMID: 25707712, DOI: 10.1016/j.bbr.2015.02.028.Peer-Reviewed Original ResearchConceptsSynthetic oxytocinInfant developmentICD-10 DCRSingleton live birthsAugmentation of laborAutistic disorderDose-dependent effectAugment laborMaternal exposureLive birthsModest associationEpidemiological analysisAdverse effectsOxytocinPlausible associationRiskMalesInconsistent findingsDisordersFuture studiesBirthAssociationAutismFindingsAugmentation
1999
Oxytocin, vasopressin, and autism: is there a connection?
Insel T, O’Brien D, Leckman J. Oxytocin, vasopressin, and autism: is there a connection? Biological Psychiatry 1999, 45: 145-157. PMID: 9951561, DOI: 10.1016/s0006-3223(98)00142-5.Peer-Reviewed Original ResearchConceptsVasopressin neurotransmissionAvailable preclinical evidencePreclinical evidenceClinical studiesAnimal studiesRodent brainPeptide receptorFeatures of autismOxytocinVasopressinGenetic disordersCompulsive behaviorsNeurotransmissionNormal expressionDevelopmental disordersSocial impairmentReceptorsCommunication deficitsDisordersSpecies-typical social behaviorsNeurobiological approachAutismEvidenceUnique effectsExpression