2000
DETECTION OF ANTIBODIES REACTIVE WITH EHRLICHIA CHAFFEENSIS IN THE RACCOON
Comer J, Nicholson W, Paddock C, Sumner J, Childs J. DETECTION OF ANTIBODIES REACTIVE WITH EHRLICHIA CHAFFEENSIS IN THE RACCOON. Journal Of Wildlife Diseases 2000, 36: 705-712. PMID: 11085432, DOI: 10.7589/0090-3558-36.4.705.Peer-Reviewed Original ResearchPrimary Isolation of Ehrlichia chaffeensis from Patients with Febrile Illnesses: Clinical and Molecular Characteristics
Standaert S, Yu T, Scott M, Childs J, Paddock C, Nicholson W, Singleton J, Blaser M. Primary Isolation of Ehrlichia chaffeensis from Patients with Febrile Illnesses: Clinical and Molecular Characteristics. The Journal Of Infectious Diseases 2000, 181: 1082-1088. PMID: 10720534, DOI: 10.1086/315346.Peer-Reviewed Original ResearchConceptsPolymerase chain reactionE. chaffeensisCerebrospinal fluid specimensCultures of bloodHigh diagnostic yieldEhrlichia chaffeensisPrimary isolationFebrile illnessDiagnostic titerBlood isolatesDiagnostic yieldTick exposureSame patientCerebrospinal fluidPatientsFluid specimensDiagnostic testsFrequent isolationBloodChain reactionChaffeensisInfectionMolecular characteristicsMolecular analysisIsolates
1999
Rats of the Genus Rattus are Reservoir Hosts for Pathogenic Bartonella Species: An Old World Origin for a New World Disease?
Ellis B, Regnery R, Beati L, Bacellar F, Rood M, Glass G, Marston E, Ksiazek T, Jones D, Childs J. Rats of the Genus Rattus are Reservoir Hosts for Pathogenic Bartonella Species: An Old World Origin for a New World Disease? The Journal Of Infectious Diseases 1999, 180: 220-224. PMID: 10353885, DOI: 10.1086/314824.Peer-Reviewed Original ResearchHidden Mortality Attributable to Rocky Mountain Spotted Fever: Immunohistochemical Detection of Fatal, Serologically Unconfirmed Disease
Paddock C, Greer P, Ferebee T, Singleton J, McKechnie D, Treadwell T, Krebs J, Clarke M, Holman R, Olson J, Childs J, Zaki S. Hidden Mortality Attributable to Rocky Mountain Spotted Fever: Immunohistochemical Detection of Fatal, Serologically Unconfirmed Disease. The Journal Of Infectious Diseases 1999, 179: 1469-1476. PMID: 10228069, DOI: 10.1086/314776.Peer-Reviewed Original ResearchConceptsCase fatality ratioDiagnosis of RMSFIHC stainingRocky Mountain Spotted FeverLaboratory-confirmed casesAcute-phase seraTickborne infectionHidden mortalityIgM antibodiesDiagnostic titerPolymerase chain reactionIHC findingsPatient seraSerologic assaysImmunohistochemical stainingSpotted FeverImmunohistochemical detectionFatal diseasePatientsDisease controlIndirect immunofluorescenceNotifiable diseaseDiseaseUnderestimates of mortalityTissue samplesLongitudinal study of infection with Borrelia burgdorferi in a population of Peromyscus leucopus at a Lyme disease-enzootic site in Maryland.
Hofmeister E, Ellis B, Glass G, Childs J. Longitudinal study of infection with Borrelia burgdorferi in a population of Peromyscus leucopus at a Lyme disease-enzootic site in Maryland. American Journal Of Tropical Medicine And Hygiene 1999, 60: 598-609. PMID: 10348235, DOI: 10.4269/ajtmh.1999.60.598.Peer-Reviewed Original ResearchConceptsPolymerase chain reactionB. burgdorferiJuvenile miceCross-sectional sampleEar tissueBorrelia burgdorferi infectionIxodes scapularis ticksInfected miceSusceptible miceChronic infectionOverall prevalenceIncidence rateBurgdorferi infectionHigh riskLower riskInfectionMiceInfected ticksLongitudinal sampleBorrelia burgdorferiScapularis ticksChain reactionBurgdorferiLongitudinal studyIndirect transmission
1995
Ehrlichiosis in a Golf-Oriented Retirement Community
Standaert S, Dawson J, Schaffner W, Childs J, Biggie K, Singleton J, Gerhardt R, Knight M, Hutcheson R. Ehrlichiosis in a Golf-Oriented Retirement Community. New England Journal Of Medicine 1995, 333: 420-425. PMID: 7616991, DOI: 10.1056/nejm199508173330704.Peer-Reviewed Original ResearchConceptsE. chaffeensis infectionCase-control studySerologic testingCommunity AMedical history reviewLone star tickRisk of infectionCommunity BAnnual incidenceSerologic evidencePolymerase chain reactionTick biteRetirement communityInfectionEhrlichiosisEndemic diseaseChain reactionEhrlichia chaffeensisHigh rateSurvey participantsPercentTicksInsect repellentOutbreakRecreational activitiesEAR BIOPSY LOCATION INFLUENCES DETECTION OF BORRELIA BURGDORFERI BY PCR, BUT NOT BY CULTURE IN NATURALLY INFECTED PEROMYSCUS LEUCOPUS
Hofmeister E, Childs J. EAR BIOPSY LOCATION INFLUENCES DETECTION OF BORRELIA BURGDORFERI BY PCR, BUT NOT BY CULTURE IN NATURALLY INFECTED PEROMYSCUS LEUCOPUS. Journal Of Wildlife Diseases 1995, 31: 345-351. PMID: 8592355, DOI: 10.7589/0090-3558-31.3.345.Peer-Reviewed Original ResearchConceptsEar biopsy samplesPolymerase chain reactionBiopsy samplesBiopsy locationB. burgdorferiBorrelia burgdorferiInfected micePeripheral samplesIndividual miceInfection statusMore tissue samplesMiceTissue samplesHigh concordanceChain reactionOrgan cultureBurgdorferiGreater frequencyEar samplesWhite-footed miceEnzootic areaEarCentral sample
1992
Comparison of polymerase chain reaction and culture for detection of Borrelia burgdorferi in naturally infected Peromyscus leucopus and experimentally infected C.B-17 scid/scid mice
Hofmeister E, Markham R, Childs J, Arthur R. Comparison of polymerase chain reaction and culture for detection of Borrelia burgdorferi in naturally infected Peromyscus leucopus and experimentally infected C.B-17 scid/scid mice. Journal Of Clinical Microbiology 1992, 30: 2625-2631. PMID: 1400962, PMCID: PMC270489, DOI: 10.1128/jcm.30.10.2625-2631.1992.Peer-Reviewed Original Research