2020
Hormonal Regulation of Cholangiocyte Secretion
Gigliozzi A, Fraioli F, Boyer J. Hormonal Regulation of Cholangiocyte Secretion. 2020, 89-95. DOI: 10.1201/9780367813888-8.Peer-Reviewed Original ResearchVasoactive intestinal peptideCholangiocyte secretionBicarbonate secretionBicarbonate-rich choleresisPost-prandial phaseExert inhibitory effectsCGMP-independent pathwayBicarbonate excretionIntestinal peptideParasympathetic systemPKA-dependent pathwayHepatic bileCholangiocyte proliferationActivation of calcineurinMaximal stimulationInhibitory effectSecretionBicarbonate requirementEnhanced expressionAdenylyl cyclaseHormonal regulationDigestive functionMajor determinantActivationCorticosteroids
1999
Vasoactive intestinal polypeptide is a potent regulator of bile secretion from rat cholangiocytes
Cho W, Boyer J. Vasoactive intestinal polypeptide is a potent regulator of bile secretion from rat cholangiocytes. Gastroenterology 1999, 117: 420-428. PMID: 10419925, DOI: 10.1053/gast.1999.0029900420.Peer-Reviewed Original ResearchConceptsBile duct unitsEffect of VIPBile flowBile secretionDuct unitsIntestinal polypeptideFluid secretionBile duct-ligated ratsBile salt outputVasoactive intestinal polypeptideHepatocyte coupletsDose-dependent increaseDuct-ligated ratsBile pHVIP antagonistSite of actionSubstance PSecretory responseVIP responsesReceptor inhibitorsCAMP-independent pathwayBicarbonate secretionPotent stimulantSalt outputAbstractTextCharacterization of ion transport mechanisms involved in bombesin-stimulated biliary secretion in rat cholangiocytes
Cho W, Boyer J. Characterization of ion transport mechanisms involved in bombesin-stimulated biliary secretion in rat cholangiocytes. Journal Of Hepatology 1999, 30: 1045-1051. PMID: 10406182, DOI: 10.1016/s0168-8278(99)80258-x.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAcetazolamideAnimalsBarium CompoundsBileBile DuctsBombesinCarbonic Anhydrase InhibitorsChloride ChannelsChloridesIn Vitro TechniquesIon TransportMaleMicroscopy, VideoNitrobenzoatesPotassium ChannelsRatsRats, Sprague-DawleyTetraethylammonium
1997
Bombesin stimulates bicarbonate secretion from rat cholangiocytes: Implications for neural regulation of bile secretion
Cho W, Mennone A, Rydberg, Boyer J. Bombesin stimulates bicarbonate secretion from rat cholangiocytes: Implications for neural regulation of bile secretion. Gastroenterology 1997, 113: 311-321. PMID: 9207292, DOI: 10.1016/s0016-5085(97)70109-4.Peer-Reviewed Original ResearchConceptsBile secretionBicarbonate secretionRat liverBile duct-ligated ratsRole of bombesinHepatocyte coupletsEffect of bombesinDose-dependent increaseDuct-ligated ratsBile duct unitsCanalicular bile secretionBile pHSite of actionBile flowSubstance PReceptor inhibitorsNeural regulationAbstractTextBombesinBiliary transportDuct unitsSecretionLiverLuminal pHRat cholangiocytes
1993
Effect of secretion on intracellular pH regulation in isolated rat bile duct epithelial cells.
Alvaro D, Cho W, Mennone A, Boyer J. Effect of secretion on intracellular pH regulation in isolated rat bile duct epithelial cells. Journal Of Clinical Investigation 1993, 92: 1314-1325. PMID: 8397224, PMCID: PMC288273, DOI: 10.1172/jci116705.Peer-Reviewed Original ResearchConceptsBile duct epithelial cellsDuct epithelial cellsCl-/HCO3Cell depolarizationEpithelial cellsEffect of secretinCl- channel blockerEffects of secretionsCl removalCl- channel activationRat bile duct epithelial cellsKRB mediumMaximal rateRegulation of intracellularBicarbonate secretionNormal rat liverIntracellular pH regulationMM DIDSHCO3- excretionAcid loadBDE cellsSecretinMicrofluorimetric methodRat liverHCO3- influx