Featured Publications
Imaging and optogenetic modulation of vascular mural cells in the live brain
Tong L, Hill RA, Damisah EC, Murray KN, Yuan P, Bordey A, Grutzendler J. Imaging and optogenetic modulation of vascular mural cells in the live brain. Nature Protocols 2020, 16: 472-496. PMID: 33299155, DOI: 10.1038/s41596-020-00425-w.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsRegional cerebral blood flowMural cellsBlood-brain barrier maintenanceCerebral ischemia mouse modelAge-related neurodegenerative diseasesCerebral blood flowSmooth muscle cell physiologyBrain blood vesselsIschemia mouse modelVascular mural cellsBrain microvesselsHigh-resolution intravital imagingVascular disordersMouse modelBlood flowMuscle cell physiologyTransgenic miceCalcium transientsAlzheimer's diseaseCalcium imagingCell subtypesBarrier maintenanceNeurodegenerative diseasesTwo-photon optogeneticsBlood vessels
2021
Intravital Imaging of Neocortical Heterotopia Reveals Aberrant Axonal Pathfinding and Myelination around Ectopic Neurons
Li AM, Hill RA, Grutzendler J. Intravital Imaging of Neocortical Heterotopia Reveals Aberrant Axonal Pathfinding and Myelination around Ectopic Neurons. Cerebral Cortex 2021, 31: 4340-4356. PMID: 33877363, PMCID: PMC8328209, DOI: 10.1093/cercor/bhab090.Peer-Reviewed Original ResearchConceptsNeuronal clustersEarly postnatal developmentVivo calcium imagingEctopic neuronal clustersAxonal patternNeocortical heterotopiaHeterotopic neuronsCortical heterotopiaHeterotopia formationEctopic neuronsAnimal modelsTractable animal modelPostnatal developmentCalcium imagingBrain regionsInducible modelIntravital imagingNeuronsAxonal pathfindingAberrant patternsHeterotopiaMyelinationAxon guidanceCognitive disabilitiesLive mice