Featured Publications
IL‐1β Drives Production of FGF‐23 at the Onset of Chronic Kidney Disease in Mice
McKnight Q, Jenkins S, Li X, Nelson T, Marlier A, Cantley LG, Finberg KE, Fretz JA. IL‐1β Drives Production of FGF‐23 at the Onset of Chronic Kidney Disease in Mice. Journal Of Bone And Mineral Research 2020, 35: 1352-1362. PMID: 32154933, PMCID: PMC7363582, DOI: 10.1002/jbmr.4003.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseOnset of CKDEarly chronic kidney diseaseFGF-23 expressionFGF-23Renal dysfunctionParathyroid hormoneIL-1βCongenital chronic kidney diseaseFGF-23 levelsSerum parathyroid hormoneGlomerular capillary tuftCongenital modelSerum phosphateIron bioavailabilitySystemic elevationVitamin DInflammatory cytokinesKidney diseaseEarly biomarkersIron statusMouse modelPhosphate imbalanceInitial upregulationCapillary tuft
2014
Early B Cell Factor 1 Regulates Adipocyte Morphology and Lipolysis in White Adipose Tissue
Gao H, Mejhert N, Fretz JA, Arner E, Lorente-Cebrián S, Ehrlund A, Dahlman-Wright K, Gong X, Strömblad S, Douagi I, Laurencikiene J, Dahlman I, Daub CO, Rydén M, Horowitz MC, Arner P. Early B Cell Factor 1 Regulates Adipocyte Morphology and Lipolysis in White Adipose Tissue. Cell Metabolism 2014, 19: 981-992. PMID: 24856929, PMCID: PMC4109056, DOI: 10.1016/j.cmet.2014.03.032.Peer-Reviewed Original ResearchAdipocytesAdipogenesisAdipose Tissue, WhiteAdiposityAnimalsCells, CulturedDiabetes MellitusDiet, High-FatFemaleGene ExpressionHumansHypertrophyInflammationInsulin ResistanceLipolysisMaleMiceMice, Inbred C57BLMice, KnockoutRNA InterferenceRNA, Small InterferingTrans-ActivatorsTumor Necrosis Factor-alpha
2012
Sclerostin: A new mediator of crosstalk between the skeletal and immune systems*
Horowitz MC, Fretz JA. Sclerostin: A new mediator of crosstalk between the skeletal and immune systems*. Journal Of Bone And Mineral Research 2012, 27: 1448-1450. PMID: 22706900, DOI: 10.1002/jbmr.1672.Commentaries, Editorials and Letters
2011
Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling
Festa E, Fretz J, Berry R, Schmidt B, Rodeheffer M, Horowitz M, Horsley V. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling. Cell 2011, 146: 761-771. PMID: 21884937, PMCID: PMC3298746, DOI: 10.1016/j.cell.2011.07.019.Peer-Reviewed Original ResearchConceptsAdipocyte lineage cellsStem cell nicheStem cell activityLineage cellsCell nicheSkin stem cell nichesStem cell functionEpithelial stem cell nicheStem cell activationEpithelial stem cell functionSkin stem cellsTissue homeostasisNiche cellsFunctional analysisAdipogenic cellsSkin homeostasisMammalian skinTransplantation experimentsStem cellsPrecursor cellsHair cyclingCell functionAdipocyte cellsNicheFunctional tissue
2009
Regulation of Aryl Hydrocarbon Receptor Function by Selective Estrogen Receptor Modulators
DuSell CD, Nelson ER, Wittmann BM, Fretz JA, Kazmin D, Thomas RS, Pike JW, McDonnell DP. Regulation of Aryl Hydrocarbon Receptor Function by Selective Estrogen Receptor Modulators. Endocrinology 2009, 24: 33-46. PMID: 19901195, PMCID: PMC2802893, DOI: 10.1210/me.2009-0339.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAryl Hydrocarbon Receptor Nuclear TranslocatorBreast NeoplasmsCell DifferentiationCell LineCell Line, TumorChromatin ImmunoprecipitationDose-Response Relationship, DrugFemaleGene Expression ProfilingGene Expression RegulationHumansMaleMiceOsteoclastsReceptors, Aryl HydrocarbonReceptors, EstrogenRecombinant ProteinsSelective Estrogen Receptor ModulatorsTamoxifenConceptsSelective estrogen receptor modulatorsAryl hydrocarbon receptorEstrogen receptor modulatorsEstrogen receptorReceptor modulatorsBreast cancerAbsence of ERER-independent mannerAryl hydrocarbon receptor functionAgonist/antagonist activityActivity of drugsAhR target genesEstradiol metabolismPharmacological actionsOsteoclast differentiationTamoxifenTherapeutic efficacyActive metaboliteReceptor functionAntagonist activityHydrocarbon receptorCalcium signalingCellular proliferationPotential roleCellular model
2007
Targeted Deletion of a Distant Transcriptional Enhancer of the Receptor Activator of Nuclear Factor-κB Ligand Gene Reduces Bone Remodeling and Increases Bone Mass
Galli C, Zella LA, Fretz JA, Fu Q, Pike JW, Weinstein RS, Manolagas SC, O’Brien C. Targeted Deletion of a Distant Transcriptional Enhancer of the Receptor Activator of Nuclear Factor-κB Ligand Gene Reduces Bone Remodeling and Increases Bone Mass. Endocrinology 2007, 149: 146-153. PMID: 17932217, PMCID: PMC2194617, DOI: 10.1210/en.2007-0734.Peer-Reviewed Original Research