Polymorphisms of COMT and CREB1 are associated with treatment-resistant depression in a Chinese Han population
Wang Y, Li S, Niu L, Ma Y, Qiu Y, Li S, Guobule N, Cao H, Li J. Polymorphisms of COMT and CREB1 are associated with treatment-resistant depression in a Chinese Han population. Journal Of Neural Transmission 2021, 129: 85-93. PMID: 34767111, DOI: 10.1007/s00702-021-02415-y.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesCatechol O-MethyltransferaseChinaCyclic AMP Response Element-Binding ProteinDepressive Disorder, MajorGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansPolymorphism, Single NucleotideConceptsTreatment-resistant depressionHamilton Depression Rating Scale-17Catechol-O-methyltransferaseCyclic AMP response element binding proteinRisk of treatment-resistant depressionPathophysiology of treatment-resistant depressionCREB1 geneAssociated with treatment-resistant depressionAssociated with antidepressant responseTreatment-resistant depressed patientsCatechol-O-methyltransferase rs4680Polymorphism of catechol-O-methyltransferaseCatechol-O-methyltransferase geneHDRS total scoreSymptoms of MDDNon-TRD groupAntidepressant responseAMP response element binding proteinDepressive disorderCREB1 polymorphismsDepressive symptomsTotal scoreSingle nucleotide polymorphismsGene-gene interaction effectsElement-binding protein