2024
Targeted metabolomics-based understanding of the sleep disturbances in drug-naïve patients with schizophrenia
Yan H, Li G, Zhang X, Zhang C, Li M, Qiu Y, Sun W, Dong Y, Li S, Li J. Targeted metabolomics-based understanding of the sleep disturbances in drug-naïve patients with schizophrenia. BMC Psychiatry 2024, 24: 355. PMID: 38741058, PMCID: PMC11089724, DOI: 10.1186/s12888-024-05805-0.Peer-Reviewed Original ResearchConceptsPositive and Negative Symptom ScaleDrug-naive patientsLiquid chromatography-mass spectrometryDrug-naive schizophreniaAssociated with sleep disturbancesOrthogonal partial least squares discriminant analysisSleep disturbancePittsburgh Sleep Quality IndexPartial least-squares discriminant analysisMetabolomics-based approachNegative Symptom ScaleChromatography-mass spectrometryCharacteristic metabolitesSchizophreniaSymptom ScaleMethodsPlasma samplesPotential biological mechanismsSleep Quality IndexClinical symptomsGlycerophospholipid metabolismPartial correlation analysisHealthy controlsMetabolomic analysisPatientsBackgroundSleep disturbance
2023
Associations between metabolic disorders and sleep disturbance in patients with schizophrenia
Yan H, Huang Z, Lu Y, Qiu Y, Li M, Li J. Associations between metabolic disorders and sleep disturbance in patients with schizophrenia. Comprehensive Psychiatry 2023, 122: 152369. PMID: 36702060, DOI: 10.1016/j.comppsych.2023.152369.Peer-Reviewed Original ResearchConceptsPositive and Negative Symptom ScaleSubjective sleep qualitySleep disturbanceSleep latencyPittsburgh Sleep Quality IndexSleep qualityNegative Symptom ScaleDuration of illnessLonger sleep latencySchizophrenia patientsDrug-naiveRate of MDSchizophreniaAssociated with MDSymptom ScaleMental illnessSleep Quality IndexTotal scorePartial correlation analysisImprove sleep qualityMetabolic disordersDevelopment of MDPredictors of MDBody mass indexClinical correlates