Ghrelin and depressive symptoms in patients with first‐episode drug‐naïve major depressive disorder: The mediating role of hypothalamic‐pituitary‐adrenal axis
Zhang C, Dong Y, Li S, Li M, Gao Y, Liu Y, Liu X, Zhou C, Li J. Ghrelin and depressive symptoms in patients with first‐episode drug‐naïve major depressive disorder: The mediating role of hypothalamic‐pituitary‐adrenal axis. Asia-Pacific Psychiatry 2024, 16: e12552. PMID: 38348641, DOI: 10.1111/appy.12552.Peer-Reviewed Original ResearchConceptsFirst-episode drug-naive MDD patientsMajor depressive disorderHAMD total scoreDrug-naive MDD patientsMDD patientsDepressive symptomsCorticotropin-releasing-hormoneTotal scoreDepressive disorderPathogenesis of major depressive disorderMeasures of depressive symptomsHealthy controlsHypothalamic-pituitary-adrenal axisHamilton Depression ScaleBody mass indexAdrenocorticotropic hormoneHAMD-17Plasma levels of ghrelinGhrelin levelsMediation analysisHAMDPartial correlation analysisDepression ScaleCortisol levelsLevels of ghrelin