2024
Dissecting the association between gut microbiota, body mass index and specific depressive symptoms: a mediation Mendelian randomisation study
Yu T, Chen C, Yang Y, Wang M, Yang Y, Feng W, Yuan S, Ma X, Li J, Zhang B. Dissecting the association between gut microbiota, body mass index and specific depressive symptoms: a mediation Mendelian randomisation study. General Psychiatry 2024, 37: e101412. PMID: 38975363, PMCID: PMC11227829, DOI: 10.1136/gpsych-2023-101412.Peer-Reviewed Original ResearchActinobacteria phylumGut microbiotaBody mass indexSpecific depressive symptomsDepressive symptomsMendelian randomisationGenome-wide association studiesTwo-sample Mendelian randomisationMass indexDepressed moodAppetite changesMendelian randomisation studiesBifidobacteriaceae familyAssociation studiesActinobacteriaPhylumMR analysisGenusFamily XIMicrobiotaObservational studyMediation analysisClinical practiceGutProtective effectGhrelin and depressive symptoms in patients with first‐episode drug‐naïve major depressive disorder: The mediating role of hypothalamic‐pituitary‐adrenal axis
Zhang C, Dong Y, Li S, Li M, Gao Y, Liu Y, Liu X, Zhou C, Li J. Ghrelin and depressive symptoms in patients with first‐episode drug‐naïve major depressive disorder: The mediating role of hypothalamic‐pituitary‐adrenal axis. Asia-Pacific Psychiatry 2024, 16: e12552. PMID: 38348641, DOI: 10.1111/appy.12552.Peer-Reviewed Original ResearchConceptsFirst-episode drug-naive MDD patientsMajor depressive disorderHAMD total scoreDrug-naive MDD patientsMDD patientsDepressive symptomsCorticotropin-releasing-hormoneTotal scoreDepressive disorderPathogenesis of major depressive disorderMeasures of depressive symptomsHealthy controlsHypothalamic-pituitary-adrenal axisHamilton Depression ScaleBody mass indexAdrenocorticotropic hormoneHAMD-17Plasma levels of ghrelinGhrelin levelsMediation analysisHAMDPartial correlation analysisDepression ScaleCortisol levelsLevels of ghrelin
2023
Autophagy markers, cognitive deficits and depressive symptoms in Parkinson’s disease
Li Y, Yang H, Zhao P, Yang J, Yao C, Zhou C, Yang C, Sun X, Li S, Li J. Autophagy markers, cognitive deficits and depressive symptoms in Parkinson’s disease. Journal Of Neural Transmission 2023, 131: 73-81. PMID: 37801108, DOI: 10.1007/s00702-023-02702-w.Peer-Reviewed Original ResearchConceptsDepressed PD patientsDepressive symptomsNaming abilityPD patientsHamilton Depression Rating Scale-17Cognitive impairmentNon-depressed PD patientsLC3-II/LC3-IAssociated with delayed recallParkinson's diseaseAssociated with cognitive functionAssociated with MoCA scoresHAMD-17Cognitive deficitsMontreal Cognitive AssessmentDelayed recallCognitive functionCognitive AssessmentGlycolipid parametersAutophagy markersMoCA scoresSymptomsMotor functionImpairmentRecall
2022
Abnormal dynamic functional network connectivity in first-episode, drug-naïve patients with major depressive disorder
Yang W, Wang Y, Qin W, Li M, Mao H, Zhou C, Liu X, Li J. Abnormal dynamic functional network connectivity in first-episode, drug-naïve patients with major depressive disorder. Journal Of Affective Disorders 2022, 319: 336-343. PMID: 36084757, DOI: 10.1016/j.jad.2022.08.072.Peer-Reviewed Original ResearchConceptsHamilton Depression Rating ScaleFirst-episodeDrug-naive patientsFunctional network connectivityDynamic functional network connectivityFeatures of spontaneous brain activityDepression Rating ScaleFunctional brain networksSpontaneous brain activityGender-matched healthy controlsMDD patientsDepressive disorderReceiver operating characteristicDepressive symptomsMDDBrain networksBrain activityConnectivity statesRating ScaleReceiver operating characteristic curve analysisHealthy controlsNetwork connectivityMRI scansDiagnostic performanceCurve analysis
2021
Polymorphisms of COMT and CREB1 are associated with treatment-resistant depression in a Chinese Han population
Wang Y, Li S, Niu L, Ma Y, Qiu Y, Li S, Guobule N, Cao H, Li J. Polymorphisms of COMT and CREB1 are associated with treatment-resistant depression in a Chinese Han population. Journal Of Neural Transmission 2021, 129: 85-93. PMID: 34767111, DOI: 10.1007/s00702-021-02415-y.Peer-Reviewed Original ResearchConceptsTreatment-resistant depressionHamilton Depression Rating Scale-17Catechol-O-methyltransferaseCyclic AMP response element binding proteinRisk of treatment-resistant depressionPathophysiology of treatment-resistant depressionCREB1 geneAssociated with treatment-resistant depressionAssociated with antidepressant responseTreatment-resistant depressed patientsCatechol-O-methyltransferase rs4680Polymorphism of catechol-O-methyltransferaseCatechol-O-methyltransferase geneHDRS total scoreSymptoms of MDDNon-TRD groupAntidepressant responseAMP response element binding proteinDepressive disorderCREB1 polymorphismsDepressive symptomsTotal scoreSingle nucleotide polymorphismsGene-gene interaction effectsElement-binding proteinThe correlation of facial emotion recognition in patients with drug-naïve depression and suicide ideation
Wang Y, Guobule N, Li M, Li J. The correlation of facial emotion recognition in patients with drug-naïve depression and suicide ideation. Journal Of Affective Disorders 2021, 295: 250-254. PMID: 34482056, DOI: 10.1016/j.jad.2021.08.051.Peer-Reviewed Original ResearchConceptsMajor depressive disorderFacial emotion recognitionMajor depressive disorder patientsSuicidal ideationEmotion recognitionFirst-episodeSuicide riskBeck Scale for Suicide Ideation-Chinese VersionHamilton Depression Rating Scale-17Facial Emotion Recognition TestAssessment of Neuropsychological StatusRisk of suicidal behaviorDrug-naive outpatientsNeutral facial expressionsEmotion Recognition TestEpisodes of depressionPerceived social isolationHDRS-17Repeatable BatteryDepressive disorderSuicidal behaviorNeuropsychological statusFacial emotionsRecognition testDepressive symptoms