2024
Sex differences in correlates of suicide attempts in Chinese Han first‐episode and drug‐naïve major depressive disorder with comorbid subclinical hypothyroidism: A cross‐sectional study
Tian X, Liu X, Bai F, Li M, Qiu Y, Jiao Q, Li J, Zhang X. Sex differences in correlates of suicide attempts in Chinese Han first‐episode and drug‐naïve major depressive disorder with comorbid subclinical hypothyroidism: A cross‐sectional study. Brain And Behavior 2024, 14: e3578. PMID: 38844426, PMCID: PMC11156525, DOI: 10.1002/brb3.3578.Peer-Reviewed Original ResearchConceptsPositive and Negative Syndrome ScaleHamilton Depression ScaleHamilton Anxiety ScaleFEDN MDD patientsMDD patientsSuicide attemptsSex differencesDepressive disorderFirst-episodeFactors associated with suicide attemptsRisk of suicide attemptNegative Syndrome ScaleMajor depressive disorderHamilton Depression Scale scoresHamilton Anxiety Scale scoresThyroid peroxidase antibodySubclinical hypothyroidismIncreased suicide attemptsInvestigate sex differencesSignificant sex differencesSyndrome ScalePositive subscaleIncreased riskAnxiety ScaleFEDNSex differences and risk factors of self-reported suicide attempts in middle-aged Chinese Han patients with first-episode drug-naïve anxious depression: a large-scale cross-sectional study
Luo G, Wang S, Gou L, Li C, Yao C, Jing Y, Xuekelaiti Z, Li J, Zhang X. Sex differences and risk factors of self-reported suicide attempts in middle-aged Chinese Han patients with first-episode drug-naïve anxious depression: a large-scale cross-sectional study. Journal Of Neural Transmission 2024, 131: 987-998. PMID: 38743092, DOI: 10.1007/s00702-024-02779-x.Peer-Reviewed Original ResearchFirst-episode drug-naiveSelf-reported suicide attemptsAnxious depressionSuicide attemptsSex differencesHamilton Anxiety Rating Scale scoresAnxiety Rating Scale scoresClinical characteristics of suicide attemptersCharacteristics of suicide attemptersMajor depressive disorderNon-suicide attemptersSelf-reported suicidalityAD patientsRating Scale scoresInvestigate sex differencesMale AD patientsDepressive disorderDrug-naiveClinical psychiatristsSevere anxietySex-specific risk factorsMiddle-aged patientsDepressionThyroid peroxidase antibodyScale scoreThe influence of gender-specific factors influencing severe anxiety in psychotic major depression: role of thyroid hormones and depression severity
Luo G, Jing Y, Yang J, Wang S, Xuekelaiti Z, Yao C, Gao Y, Chen H, Sun D, Li J, Zhang X. The influence of gender-specific factors influencing severe anxiety in psychotic major depression: role of thyroid hormones and depression severity. Journal Of Neural Transmission 2024, 131: 833-845. PMID: 38693463, DOI: 10.1007/s00702-024-02781-3.Peer-Reviewed Original ResearchHamilton Depression Rating ScalePositive and Negative Syndrome ScaleHamilton Depression Rating Scale scoresClinical Global Impressions-SeverityHamilton Anxiety Rating ScaleDepression severitySevere anxietyMDD patientsMajor depressionPMD patientsNon-psychotic MDD patientsRating ScaleThyroid-stimulating hormoneNegative Syndrome ScalePsychotic major depressionDepression Rating ScaleThyroid-stimulating hormone levelsAnxiety Rating ScaleIncreased depression severityAssociated with anxietyNo significant gender differencesSyndrome ScalePrevalence of severe anxietyPsychotic symptomsDepressive disorderAssociation between peripheral plasma cytokine levels and suicidal ideation in first-episode, drug-naïve major depressive disorder
Tian X, Dong Y, Yuan J, Gao Y, Zhang C, Li M, Li J. Association between peripheral plasma cytokine levels and suicidal ideation in first-episode, drug-naïve major depressive disorder. Psychoneuroendocrinology 2024, 165: 107042. PMID: 38613945, DOI: 10.1016/j.psyneuen.2024.107042.Peer-Reviewed Original ResearchBeck Scale for Suicide Ideation-Chinese VersionChildhood Trauma QuestionnaireSuicidal ideationMDD patientsDepressive disorderFirst-episode drug-naive MDD patientsHamilton Depression Rating Scale-17Drug-naive MDD patientsIL-2 levelsMajor depressive disorderIL-2Plasma levelsIL-10HAMD-17First-episodeChildhood traumaTrauma QuestionnaireIL-8IL-6Plasma IL-2 levelsSuicide riskPlasma levels of cytokinesHAMA-14Stratified analysisIdeationGhrelin and depressive symptoms in patients with first‐episode drug‐naïve major depressive disorder: The mediating role of hypothalamic‐pituitary‐adrenal axis
Zhang C, Dong Y, Li S, Li M, Gao Y, Liu Y, Liu X, Zhou C, Li J. Ghrelin and depressive symptoms in patients with first‐episode drug‐naïve major depressive disorder: The mediating role of hypothalamic‐pituitary‐adrenal axis. Asia-Pacific Psychiatry 2024, 16: e12552. PMID: 38348641, DOI: 10.1111/appy.12552.Peer-Reviewed Original ResearchConceptsFirst-episode drug-naive MDD patientsMajor depressive disorderHAMD total scoreDrug-naive MDD patientsMDD patientsDepressive symptomsCorticotropin-releasing-hormoneTotal scoreDepressive disorderPathogenesis of major depressive disorderMeasures of depressive symptomsHealthy controlsHypothalamic-pituitary-adrenal axisHamilton Depression ScaleBody mass indexAdrenocorticotropic hormoneHAMD-17Plasma levels of ghrelinGhrelin levelsMediation analysisHAMDPartial correlation analysisDepression ScaleCortisol levelsLevels of ghrelinPlasma oxidative stress marker levels related to functional brain abnormalities in first-episode drug-naive major depressive disorder
Liu Y, Zhang B, Zhou Y, Li M, Gao Y, Qin W, Xie Y, Liu W, Jing Y, Li J. Plasma oxidative stress marker levels related to functional brain abnormalities in first-episode drug-naive major depressive disorder. Psychiatry Research 2024, 333: 115742. PMID: 38232568, DOI: 10.1016/j.psychres.2024.115742.Peer-Reviewed Original ResearchConceptsMajor depressive disorderMajor depressive disorder patientsAmplitude of low-frequency fluctuationDepressive disorderSuicidal ideationWhole-brain functional connectivity analysisMDD pathophysiologyDrug-naive MDD patientsResting-state fMRI scansAmplitude of low-frequency fluctuation valuesFunctional brain abnormalitiesAnterior cingulate gyrusSuperior frontal gyrusFunctional connectivity analysisOxidative stress markersAbnormal brain functionLow-frequency fluctuationsPlasma oxidative stress markersMDD patientsFrontal gyrusFMRI scanningFirst-episodeCingulate gyrusBrain regionsConnectivity analysis
2022
Abnormal dynamic functional network connectivity in first-episode, drug-naïve patients with major depressive disorder
Yang W, Wang Y, Qin W, Li M, Mao H, Zhou C, Liu X, Li J. Abnormal dynamic functional network connectivity in first-episode, drug-naïve patients with major depressive disorder. Journal Of Affective Disorders 2022, 319: 336-343. PMID: 36084757, DOI: 10.1016/j.jad.2022.08.072.Peer-Reviewed Original ResearchConceptsHamilton Depression Rating ScaleFirst-episodeDrug-naive patientsFunctional network connectivityDynamic functional network connectivityFeatures of spontaneous brain activityDepression Rating ScaleFunctional brain networksSpontaneous brain activityGender-matched healthy controlsMDD patientsDepressive disorderReceiver operating characteristicDepressive symptomsMDDBrain networksBrain activityConnectivity statesRating ScaleReceiver operating characteristic curve analysisHealthy controlsNetwork connectivityMRI scansDiagnostic performanceCurve analysis
2021
Polymorphisms of COMT and CREB1 are associated with treatment-resistant depression in a Chinese Han population
Wang Y, Li S, Niu L, Ma Y, Qiu Y, Li S, Guobule N, Cao H, Li J. Polymorphisms of COMT and CREB1 are associated with treatment-resistant depression in a Chinese Han population. Journal Of Neural Transmission 2021, 129: 85-93. PMID: 34767111, DOI: 10.1007/s00702-021-02415-y.Peer-Reviewed Original ResearchConceptsTreatment-resistant depressionHamilton Depression Rating Scale-17Catechol-O-methyltransferaseCyclic AMP response element binding proteinRisk of treatment-resistant depressionPathophysiology of treatment-resistant depressionCREB1 geneAssociated with treatment-resistant depressionAssociated with antidepressant responseTreatment-resistant depressed patientsCatechol-O-methyltransferase rs4680Polymorphism of catechol-O-methyltransferaseCatechol-O-methyltransferase geneHDRS total scoreSymptoms of MDDNon-TRD groupAntidepressant responseAMP response element binding proteinDepressive disorderCREB1 polymorphismsDepressive symptomsTotal scoreSingle nucleotide polymorphismsGene-gene interaction effectsElement-binding proteinThe correlation of facial emotion recognition in patients with drug-naïve depression and suicide ideation
Wang Y, Guobule N, Li M, Li J. The correlation of facial emotion recognition in patients with drug-naïve depression and suicide ideation. Journal Of Affective Disorders 2021, 295: 250-254. PMID: 34482056, DOI: 10.1016/j.jad.2021.08.051.Peer-Reviewed Original ResearchConceptsMajor depressive disorderFacial emotion recognitionMajor depressive disorder patientsSuicidal ideationEmotion recognitionFirst-episodeSuicide riskBeck Scale for Suicide Ideation-Chinese VersionHamilton Depression Rating Scale-17Facial Emotion Recognition TestAssessment of Neuropsychological StatusRisk of suicidal behaviorDrug-naive outpatientsNeutral facial expressionsEmotion Recognition TestEpisodes of depressionPerceived social isolationHDRS-17Repeatable BatteryDepressive disorderSuicidal behaviorNeuropsychological statusFacial emotionsRecognition testDepressive symptoms