2009
Varenicline Reduces Alcohol Self-Administration in Heavy-Drinking Smokers
McKee SA, Harrison EL, O'Malley SS, Krishnan-Sarin S, Shi J, Tetrault JM, Picciotto MR, Petrakis IL, Estevez N, Balchunas E. Varenicline Reduces Alcohol Self-Administration in Heavy-Drinking Smokers. Biological Psychiatry 2009, 66: 185-190. PMID: 19249750, PMCID: PMC2863311, DOI: 10.1016/j.biopsych.2009.01.029.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismBenzazepinesCentral Nervous System DepressantsDouble-Blind MethodEthanolFemaleHumansMaleNicotinic AgonistsQuinoxalinesSmokingVareniclineYoung AdultConceptsHeavy drinking smokersSelf-administration periodAlcohol consumptionPartial nicotinic agonistPlacebo-controlled investigationEffects of vareniclineReduced ethanol intakeAlcohol Self-AdministrationAlcohol use disorderNicotinic acetylcholine receptorsMedication pretreatmentAdverse eventsNumber of drinksPreclinical evidenceAdditional drinkEthanol intakeTobacco dependenceDaily smokersPriming doseVareniclineComorbid disordersNicotinic agonistsUse disordersPriming drinkPotential treatment
2000
Similarities in the Disturbances in Cortical Information Processing in Alcoholism and Aging: A Pilot Evoked Potential Study
Boutros N, Reid M, Petrakis I, Campbell D, Torello M, Krystal J. Similarities in the Disturbances in Cortical Information Processing in Alcoholism and Aging: A Pilot Evoked Potential Study. International Psychogeriatrics 2000, 12: 513-525. PMID: 11263717, DOI: 10.1017/s1041610200006621.Peer-Reviewed Original ResearchConceptsInformation processingCortical information processingSensory gatingPaired-click paradigmOlder healthy subjectsAlcohol dependenceSensory gating deficitsStimulus classificationNovel stimuliOddball paradigmHealthy individualsYoung healthy groupEvoked potential studiesDSM-IV criteriaPotential studiesHealthy subjectsGender-matched groupAged healthy individualsGender-matched healthy individualsGating deficitsMiddle-aged individualsPsychotic symptomsOlder groupProcessingAlcoholic patients