2018
Pharmacological and Psychological Treatments for Comorbid Alcohol Use Disorder and Depressive Disorder: a Review
Yoon G, Petrakis I. Pharmacological and Psychological Treatments for Comorbid Alcohol Use Disorder and Depressive Disorder: a Review. Current Addiction Reports 2018, 5: 312-322. DOI: 10.1007/s40429-018-0213-z.Peer-Reviewed Original ResearchComorbid alcohol use disorderAlcohol use disorderPsychological interventionsCognitive-behavioral treatmentUse disordersPsychological treatmentDepressive disorderMotivational interviewingComorbid disordersMixed resultsDisordersInterventionRecent FindingsWePharmacological interventionsCurrent reviewEffective treatmentFurther researchReviewThe goalInterviewingAntidepressantsPatientsTreatmentDepressionTrialsEfficacy
2017
Partnering with Psychiatry to Close the Education Gap: An Approach to the Addiction Epidemic
Tetrault JM, Petrakis IL. Partnering with Psychiatry to Close the Education Gap: An Approach to the Addiction Epidemic. Journal Of General Internal Medicine 2017, 32: 1387-1389. PMID: 28766126, PMCID: PMC5698217, DOI: 10.1007/s11606-017-4140-9.Peer-Reviewed Original Research
2013
Differential diagnosis for a stable patient maintained on buprenorphine who gives a urine toxicology screen negative for buprenorphine
Sethi R, Petrakis I. Differential diagnosis for a stable patient maintained on buprenorphine who gives a urine toxicology screen negative for buprenorphine. American Journal On Addictions 2013 DOI: 10.1111/j.1521-0391.2013.12087.x.Peer-Reviewed Original Research
2012
Prazosin for Treatment of Patients With PTSD and Comorbid Alcohol Dependence
Petrakis I, Ralevski E. Prazosin for Treatment of Patients With PTSD and Comorbid Alcohol Dependence. 2012 DOI: 10.21236/ada568060.Peer-Reviewed Original ResearchAlpha-1 adrenergic receptor antagonistComorbid alcohol dependenceAdrenergic receptor antagonistAlcohol dependenceReceptor antagonistAlcohol consumptionDouble-blind fashionCommon comorbid conditionsTreatment of patientsRates of PTSDCommon neurobiological mechanismsTraumatic Stress DisorderSymptoms of PTSDComorbid conditionsSleep disturbancesEffective treatmentGeneral populationTrauma nightmaresPrazosinCurrent diagnosisPatientsStress disorderNeurobiological mechanismsPTSD symptomsSymptoms
2011
Prazosin for Treatment of Patients with PTSD and Comorbid Alcohol Dependence
Petrakis I. Prazosin for Treatment of Patients with PTSD and Comorbid Alcohol Dependence. 2011 DOI: 10.21236/ada554540.Peer-Reviewed Original ResearchComorbid alcohol dependenceAdrenergic receptor antagonistAlcohol dependenceReceptor antagonistSymptoms of PTSDAlcohol consumptionTraumatic Stress DisorderCommon neurobiological mechanismsDouble-blind fashionRates of PTSDTreatment of patientsPTSD symptomsStress disorderNeurobiological mechanismsCombat veteransPTSDCommon comorbidTrauma nightmaresSleep disturbancesEffective treatmentGeneral populationPrazosinCurrent diagnosisPatientsSymptoms
2009
Pharmacotherapeutic Effects of Opioid Antagonists in Alcohol-Abusing Patients with Schizophrenia
Petrakis I. Pharmacotherapeutic Effects of Opioid Antagonists in Alcohol-Abusing Patients with Schizophrenia. Contemporary Neuroscience 2009, 473-483. DOI: 10.1007/978-1-59745-197-0_25.Peer-Reviewed Original ResearchAlcohol use disorderOpioid antagonist naltrexoneUse disordersAntagonist naltrexoneTherapeutic optionsGeneral populationSchizoaffective disorderDevastating clinical disorderOpioid antagonist treatmentBest therapeutic optionGroup of patientsUse of naltrexoneSymptoms of psychosisNoncomorbid patientsPharmacologic managementAntagonist treatmentOpioid antagonistAlcohol use/dependenceComorbid schizophreniaClinical trialsPharmacotherapeutic effectsSchizophrenic patientsPatientsSide effectsCognitive symptoms
2006
Effects of Naltrexone on Cognition in a Treatment Study of Patients with Schizophrenia and Comorbid Alcohol Dependence
Ralevski E, Balachandra K, Gueorguieva R, Limoncelli D, Petrakis I. Effects of Naltrexone on Cognition in a Treatment Study of Patients with Schizophrenia and Comorbid Alcohol Dependence. Journal Of Dual Diagnosis 2006, 2: 53-69. DOI: 10.1300/j374v02n04_05.Peer-Reviewed Original ResearchCognitive functioningAlcohol dependenceFrontal lobe functioningComorbid alcohol dependenceSymptoms of schizophreniaAlcohol useFunctioningCognitionTreatment studiesSchizophreniaEffects of naltrexoneAlcohol reductionMemoryDrinking patternsAlcohol consumptionAttentionSecond objectiveWeeks of treatmentDeficitsFirst objectiveWeek 24Naltrexone treatmentWeek 12NaltrexonePatients
2005
Setting Up a Buprenorphine Clinic
Balachandra K, Petrakis I. Setting Up a Buprenorphine Clinic. Addictive Disorders & Their Treatment 2005, 4: 111-116. DOI: 10.1097/01.adt.0000163701.68367.95.Peer-Reviewed Original ResearchBuprenorphine clinicOutpatient substance abuse clinicsSpectrum of treatmentOne-year experienceSubstance abuse clinicsOpioid dependencePharmacotherapeutic optionsOutpatient settingTreatment challengesOpioid addictionHospital settingClinicNew FDABuprenorphinePatientsMedicationsPositive experiencesSettingMazindol Augmentation of Antipsychotic Treatment for Schizophrenic Patients with Comorbid Cocaine Abuse or Dependence
Perry E, Gil R, Miles D, Brenner L, Macdougall L, Johnson R, Degen K, Gueorguieva R, Petrakis I, Krystal J, D'Souza D. Mazindol Augmentation of Antipsychotic Treatment for Schizophrenic Patients with Comorbid Cocaine Abuse or Dependence. Journal Of Dual Diagnosis 2005, 1: 37-47. DOI: 10.1300/j374v01n01_04.Peer-Reviewed Original ResearchCocaine abusePsychiatric symptomsCocaine cravingCatecholamine reuptake inhibitorCurrent antipsychotic medicationsCocaine consumptionPlacebo groupAntipsychotic pharmacotherapyReuptake inhibitorsAntipsychotic medicationAntipsychotic treatmentComorbid schizophreniaSchizoaffective patientsSubstance abuse issuesSchizophrenic patientsPatientsSchizoaffective disorderSchizophrenia patientsNatural historyMazindolPilot studyGroup therapySchizophreniaSymptomsAbuse issues
2001
Effect of Tryptophan Depletion on Alcohol Cue‐Induced Craving in Abstinent Alcoholic Patients
Petrakis I, Trevisan L, Boutros N, Limoncelli D, Cooney N, Krystal J. Effect of Tryptophan Depletion on Alcohol Cue‐Induced Craving in Abstinent Alcoholic Patients. Alcohol Clinical And Experimental Research 2001, 25: 1151-1155. PMID: 11505046, DOI: 10.1111/j.1530-0277.2001.tb02329.x.Peer-Reviewed Original ResearchConceptsCue-induced cravingAlcohol-dependent patientsTryptophan depletionAlcohol cue-induced cravingDouble-blind fashionPlasma free tryptophanAbstinent alcoholic patientsAmino acid drinkActive tryptophan depletionAlcoholic patientsSerotonin synthesisAcid drinkSober alcoholicsAlcoholic individualsPrecursor tryptophanCue exposurePatientsAlcohol useAbstinent alcoholic individualsCravingFree tryptophanAlcohol cuesTest dayGreater increaseSimilar drinks
1999
Toward a rational pharmacotherapy of comorbid substance abuse in schizophrenic patients
Krystal J, D'Souza D, Madonick S, Petrakis I. Toward a rational pharmacotherapy of comorbid substance abuse in schizophrenic patients. Schizophrenia Research 1999, 35: s35-s49. PMID: 10190224, DOI: 10.1016/s0920-9964(98)00162-5.Peer-Reviewed Original ResearchConceptsSchizophrenic patientsSubstance abuseTerms of rehospitalizationComorbid substance abuseExacerbation of symptomsHealth care expensesSelf-medication hypothesisBetter prognosisMedical illnessPharmacotherapeutic approachesRational pharmacotherapyNonschizophrenic populationsPatientsVocational functionIllicit substancesCare expensesAbuseVulnerability hypothesisRehospitalizationExacerbationMedicationsPharmacotherapyPrognosisPsychostimulantsIllness
1992
Adjunctive desipramine in the treatment of cocaine abusing schizophrenics.
Ziedonis D, Richardson T, Lee E, Petrakis I, Kosten T. Adjunctive desipramine in the treatment of cocaine abusing schizophrenics. Psychopharmacology Bulletin 1992, 28: 309-14. PMID: 1480735.Peer-Reviewed Original ResearchConceptsAntipsychotic agentsSchizophrenic patientsOpen-label outpatient studySubstance abuse relapse preventionTreatment programDual diagnosis treatment programOnly antipsychotic agentTreatment of cocaineCocaine-positive urinesLifetime prevalence ratesRelapse prevention programAdjunctive pharmacotherapyOutpatient studyPrevalence ratesPsychiatric symptomsPatientsCocaine abuseRelapse preventionPrevention programsCocaine usageDMI groupPharmacotherapyDesipramineSymptomsAgents
1991
Bupropion Reduces Cocaine Abuse in Methadone-Maintained Patients
Margolin A, Kosten T, Petrakis I, Avants S, Kosten T. Bupropion Reduces Cocaine Abuse in Methadone-Maintained Patients. JAMA Psychiatry 1991, 48: 87-87. PMID: 1898631, DOI: 10.1001/archpsyc.1991.01810250089015.Peer-Reviewed Original Research
1990
An open pilot study of bupropion and psychotherapy for the treatment of cocaine abuse in methadone-maintained patients.
Margolin A, Kosten T, Petrakis I, Avants S, Kosten T. An open pilot study of bupropion and psychotherapy for the treatment of cocaine abuse in methadone-maintained patients. NIDA Research Monograph 1990, 105: 367-8. PMID: 1908556.Peer-Reviewed Original Research