2024
Alcohol Use Disorder and Chronic Pain: An Overlooked Epidemic
De Aquino J, Sloan M, Nunes J, Costa G, Katz J, de Oliveira D, Ra J, Tang V, Petrakis I. Alcohol Use Disorder and Chronic Pain: An Overlooked Epidemic. American Journal Of Psychiatry 2024, 181: 391-402. PMID: 38706339, PMCID: PMC11521207, DOI: 10.1176/appi.ajp.20230886.Peer-Reviewed Original ResearchConceptsAlcohol use disorderChronic painAUD studiesChronic pain disordersChronic pain outcomesRisk of relapseAlcohol withdrawal syndromeAssessment of painHigher levels of alcohol consumptionLevels of alcohol consumptionWithdrawal syndromePain disordersPain outcomesAcute toleranceNeurobiological changesClinical significanceUse disorderPainClinical relevanceSelf-reportAlcohol intoxicationAlcohol consumptionGeneral populationMedical conditionsNarrative review
2012
Prazosin for Treatment of Patients With PTSD and Comorbid Alcohol Dependence
Petrakis I, Ralevski E. Prazosin for Treatment of Patients With PTSD and Comorbid Alcohol Dependence. 2012 DOI: 10.21236/ada568060.Peer-Reviewed Original ResearchAlpha-1 adrenergic receptor antagonistComorbid alcohol dependenceAdrenergic receptor antagonistAlcohol dependenceReceptor antagonistAlcohol consumptionDouble-blind fashionCommon comorbid conditionsTreatment of patientsRates of PTSDCommon neurobiological mechanismsTraumatic Stress DisorderSymptoms of PTSDComorbid conditionsSleep disturbancesEffective treatmentGeneral populationTrauma nightmaresPrazosinCurrent diagnosisPatientsStress disorderNeurobiological mechanismsPTSD symptomsSymptoms
2011
Prazosin for Treatment of Patients with PTSD and Comorbid Alcohol Dependence
Petrakis I. Prazosin for Treatment of Patients with PTSD and Comorbid Alcohol Dependence. 2011 DOI: 10.21236/ada554540.Peer-Reviewed Original ResearchComorbid alcohol dependenceAdrenergic receptor antagonistAlcohol dependenceReceptor antagonistSymptoms of PTSDAlcohol consumptionTraumatic Stress DisorderCommon neurobiological mechanismsDouble-blind fashionRates of PTSDTreatment of patientsPTSD symptomsStress disorderNeurobiological mechanismsCombat veteransPTSDCommon comorbidTrauma nightmaresSleep disturbancesEffective treatmentGeneral populationPrazosinCurrent diagnosisPatientsSymptoms
2009
Pharmacotherapeutic Effects of Opioid Antagonists in Alcohol-Abusing Patients with Schizophrenia
Petrakis I. Pharmacotherapeutic Effects of Opioid Antagonists in Alcohol-Abusing Patients with Schizophrenia. Contemporary Neuroscience 2009, 473-483. DOI: 10.1007/978-1-59745-197-0_25.Peer-Reviewed Original ResearchAlcohol use disorderOpioid antagonist naltrexoneUse disordersAntagonist naltrexoneTherapeutic optionsGeneral populationSchizoaffective disorderDevastating clinical disorderOpioid antagonist treatmentBest therapeutic optionGroup of patientsUse of naltrexoneSymptoms of psychosisNoncomorbid patientsPharmacologic managementAntagonist treatmentOpioid antagonistAlcohol use/dependenceComorbid schizophreniaClinical trialsPharmacotherapeutic effectsSchizophrenic patientsPatientsSide effectsCognitive symptoms