2009
Bone morphogenetic protein‐6 induces the expression of inducible nitric oxide synthase in macrophages
Kwon S, Lee G, Lee J, Kim W, Kim I. Bone morphogenetic protein‐6 induces the expression of inducible nitric oxide synthase in macrophages. Immunology 2009, 128: e758-e765. PMID: 19740337, PMCID: PMC2753926, DOI: 10.1111/j.1365-2567.2009.03079.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, NeutralizingBone Morphogenetic Protein 6Cells, CulturedCycloheximideDactinomycinHumansInterleukin-1betaMacrophages, PeritonealMiceNF-kappa BNitric Oxide Synthase Type IIProtein Synthesis InhibitorsRecombinant ProteinsSignal TransductionSmad ProteinsTumor Necrosis Factor-alphaConceptsBone morphogenetic proteinBMP-6Effects of BMPBone morphogenetic protein 6New protein synthesisMorphogenetic proteinsMurine macrophage cell lineMacrophage cell lineImportant regulatorProtein synthesisProtein 6Cell typesMouse peritoneal macrophagesCell linesActinomycin DNF-kappaBSmadExpressionDose-dependent mannerSynthaseNitric oxide synthasePathwayInductionInducible nitric oxide synthasePeritoneal macrophages
2002
The Human Papilloma Virus E7 Oncoprotein Inhibits Transforming Growth Factor-β Signaling by Blocking Binding of the Smad Complex to Its Target Sequence*
Lee D, Kim B, Kim I, Cho E, Satterwhite D, Kim S. The Human Papilloma Virus E7 Oncoprotein Inhibits Transforming Growth Factor-β Signaling by Blocking Binding of the Smad Complex to Its Target Sequence*. Journal Of Biological Chemistry 2002, 277: 38557-38564. PMID: 12145312, DOI: 10.1074/jbc.m206786200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCyclin-Dependent KinasesDNADNA-Binding ProteinsFemaleGenes, ReporterHumansOncogene Proteins, ViralPapillomaviridaeProtein BindingSignal TransductionSmad ProteinsTrans-ActivatorsTranscription, GeneticTransforming Growth Factor betaTransforming Growth Factor beta1Uterine Cervical NeoplasmsConceptsHuman papillomavirus (HPV) oncoprotein E7HPV-positive cellsCervical cancerTGF-beta signalingSuppression of SmadConfocal microscopic studiesE7 oncoproteinsOncoprotein E7Growth inhibitory activitySmad transcriptional activityHPVE7Inhibitory activityMicroscopic studyTranscriptional activityDNA synthesisSmadSmad proteinsSignalingEtiologyCancerInfectionPRB