2010
Bone Morphogenetic Protein Signaling: Implications in Urology
Jeong J, Kang D, Lee G, Kim I. Bone Morphogenetic Protein Signaling: Implications in Urology. Investigative And Clinical Urology 2010, 51: 511-517. PMID: 20733955, PMCID: PMC2924553, DOI: 10.4111/kju.2010.51.8.511.Peer-Reviewed Original ResearchBone morphogenetic proteinSmall molecule inhibitorsBMP signalingTransmembrane serine/threonine kinase receptorsSerine/threonine kinase receptorsSubsequent signal transduction cascadesMolecule inhibitorsFirst small-molecule inhibitorSignal transduction cascadeMultiple key stepsSmad-independent pathwaysDiverse human diseasesHeteromeric complexesTransduction cascadeEmbryonic developmentInhibitory SmadsMorphogenetic proteinsReceptor domainHuman diseasesKinase receptorsCritical functionsPathwayCritical roleNovel therapeuticsSignaling
2002
The Human Papilloma Virus E7 Oncoprotein Inhibits Transforming Growth Factor-β Signaling by Blocking Binding of the Smad Complex to Its Target Sequence*
Lee D, Kim B, Kim I, Cho E, Satterwhite D, Kim S. The Human Papilloma Virus E7 Oncoprotein Inhibits Transforming Growth Factor-β Signaling by Blocking Binding of the Smad Complex to Its Target Sequence*. Journal Of Biological Chemistry 2002, 277: 38557-38564. PMID: 12145312, DOI: 10.1074/jbc.m206786200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCyclin-Dependent KinasesDNADNA-Binding ProteinsFemaleGenes, ReporterHumansOncogene Proteins, ViralPapillomaviridaeProtein BindingSignal TransductionSmad ProteinsTrans-ActivatorsTranscription, GeneticTransforming Growth Factor betaTransforming Growth Factor beta1Uterine Cervical NeoplasmsConceptsHuman papillomavirus (HPV) oncoprotein E7HPV-positive cellsCervical cancerTGF-beta signalingSuppression of SmadConfocal microscopic studiesE7 oncoproteinsOncoprotein E7Growth inhibitory activitySmad transcriptional activityHPVE7Inhibitory activityMicroscopic studyTranscriptional activityDNA synthesisSmadSmad proteinsSignalingEtiologyCancerInfectionPRB