2023
Clinical presentation of group B Streptococcus-infected diabetic foot ulcers
Waldman O, Dexter B, Sulovari A, Oh I. Clinical presentation of group B Streptococcus-infected diabetic foot ulcers. Journal Of Wound Care 2023, 32: s19-s25. PMID: 37405964, DOI: 10.12968/jowc.2023.32.sup7.s19.Peer-Reviewed Original ResearchMeSH KeywordsDiabetes MellitusDiabetic FootHemoglobinsHumansRetrospective StudiesStreptococcusWound HealingConceptsDiabetic foot ulcersFoot ulcersBlack patientsRecurrent infectionsElevated hemoglobin A1cIntra-operative culturesHemoglobin A1c levelsInitial laboratory valuesSoft tissue infectionsDFU infectionsDFU patientsInitial surgeryOrthopaedic FootAggressive treatmentClinical characteristicsGBS infectionA1c levelsHemoglobin A1cTissue infectionsClinical outcomesClinical presentationInfected boneAppropriate treatmentGroup BLaboratory valuesTranscriptomic identification of genes expressed in invasive S. aureus diabetic foot ulcer infection
Agidigbi T, Kwon H, Knight J, Zhao D, Lee F, Oh I. Transcriptomic identification of genes expressed in invasive S. aureus diabetic foot ulcer infection. Frontiers In Cellular And Infection Microbiology 2023, 13: 1198115. PMID: 37434783, PMCID: PMC10332306, DOI: 10.3389/fcimb.2023.1198115.Peer-Reviewed Original ResearchConceptsDiabetic foot ulcersPeripheral blood mononuclear cellsHost immune responseActive infectionImmune responseDiabetic foot ulcer infectionsInfected diabetic foot ulcersFoot ulcer infectionsPatients 8 weeksIntravenous antibiotic therapyBlood mononuclear cellsWound healing statusDFU infectionsPBMC expressionSalvage therapyUlcer infectionDifferent time pointsAntibiotic therapyMajor complicationsSurgical treatmentFoot ulcersMononuclear cellsPotential intervention optionsSpecies-specific infectionTreatment response
2021
Comparative study of culture, next‐generation sequencing, and immunoassay for identification of pathogen in diabetic foot ulcer
Lipof JS, Jones CMC, Daiss J, Oh I. Comparative study of culture, next‐generation sequencing, and immunoassay for identification of pathogen in diabetic foot ulcer. Journal Of Orthopaedic Research® 2021, 39: 2638-2645. PMID: 33543785, PMCID: PMC8339135, DOI: 10.1002/jor.25001.Peer-Reviewed Original ResearchMeSH KeywordsDiabetes MellitusDiabetic FootHigh-Throughput Nucleotide SequencingHumansImmunoassayStaphylococcal InfectionsStaphylococcus aureusConceptsDiabetic foot infectionsMusculoskeletal infectionsNext-generation sequencingS. agalactiaeS. aureusCulture-directed antibioticsDeep musculoskeletal infectionNegative initial culturesProspective observational studyTime of diagnosisDiabetic foot ulcersLimb salvage effortsPeripheral blood samplesYears of ageFoot infectionsSurgical debridementFoot ulcersRecurrent infectionsTreatment successFair correlationIntraoperative samplesObservational studyBlood samplesUseful adjunctOrthopaedic surgeons
2020
Intraoperative Site Vancomycin Powder Application in Infected Diabetic Heel Ulcers With Calcaneal Osteomyelitis
Brodell JD, Kozakiewicz LN, Hoffman SL, Oh I. Intraoperative Site Vancomycin Powder Application in Infected Diabetic Heel Ulcers With Calcaneal Osteomyelitis. Foot & Ankle International 2020, 42: 356-362. PMID: 33185116, DOI: 10.1177/1071100720962480.Peer-Reviewed Original ResearchConceptsDiabetic heel ulcersVancomycin powder applicationTotal calcanectomyVancomycin powderCalcaneal osteomyelitisHeel ulcersClinical outcomesRetrospective case-control studyLimb salvage rateOverall healing rateImproved clinical outcomesCase-control studyLocal tissue irritationMultidrug-resistant bacteriaVancomycin cohortWound complicationsClinical characteristicsOperative complicationsUlcer surgeryDiabetic patientsRevision amputationSalvage rateKnee amputationClinical benefitUnderwent revision