2022
Treating ‘Septic’ With Enhanced Antibiotics and ‘Arthritis’ by Mitigation of Excessive Inflammation
Kwon HK, Dussik CM, Kim SH, Kyriakides TR, Oh I, Lee FY. Treating ‘Septic’ With Enhanced Antibiotics and ‘Arthritis’ by Mitigation of Excessive Inflammation. Frontiers In Cellular And Infection Microbiology 2022, 12: 897291. PMID: 35755835, PMCID: PMC9218192, DOI: 10.3389/fcimb.2022.897291.Peer-Reviewed Original ResearchConceptsSeptic arthritisBacterial burdenAntibiotic treatmentMurine modelTherapeutic goalsConcurrent antimicrobial therapyDistinct therapeutic goalsGeneration of inflammationMRSA septic arthritisSeptic knee arthritisInflammatory joint conditionsArticular cartilageMitigation of inflammationPost-antibiotic treatmentNovel therapeutic strategiesSeptic arthritis modelArticular cartilage damageEx vivo modelArticular cartilage integrityInflammatory arthritisInhibitors of ERKInflammatory profileMRSA infectionSynovial tissueExcessive inflammation
2020
Distinct vasculotropic versus osteotropic features of S. agalactiae versus S. aureus implant‐associated bone infection in mice
Masters EA, Hao SP, Kenney HM, Morita Y, Galloway CA, de Mesy Bentley K, Ricciardi BF, Boyce BF, Schwarz EM, Oh I. Distinct vasculotropic versus osteotropic features of S. agalactiae versus S. aureus implant‐associated bone infection in mice. Journal Of Orthopaedic Research® 2020, 39: 389-401. PMID: 33336806, PMCID: PMC7882123, DOI: 10.1002/jor.24962.Peer-Reviewed Original ResearchConceptsS. aureus osteomyelitisBone infectionS. agalactiaeAnimal modelsS. aureus bone infectionImplant looseningSoft tissueImplant-associated osteomyelitisQuantitative animal modelCortical boneAdjacent soft tissuesGroup B streptococciS. aureusSeptic implant looseningS. agalactiae infectionAssessment of miceS. aureus virulenceGreater body weightDevastating complicationClinical featuresAbscess formationLocal inflammationAggressive osteolysisLess osteolysisPreclinical models