Distinct vasculotropic versus osteotropic features of S. agalactiae versus S. aureus implant‐associated bone infection in mice
Masters EA, Hao SP, Kenney HM, Morita Y, Galloway CA, de Mesy Bentley K, Ricciardi BF, Boyce BF, Schwarz EM, Oh I. Distinct vasculotropic versus osteotropic features of S. agalactiae versus S. aureus implant‐associated bone infection in mice. Journal Of Orthopaedic Research® 2020, 39: 389-401. PMID: 33336806, PMCID: PMC7882123, DOI: 10.1002/jor.24962.Peer-Reviewed Original ResearchConceptsS. aureus osteomyelitisBone infectionS. agalactiaeAnimal modelsS. aureus bone infectionImplant looseningSoft tissueImplant-associated osteomyelitisQuantitative animal modelCortical boneAdjacent soft tissuesGroup B streptococciS. aureusSeptic implant looseningS. agalactiae infectionAssessment of miceS. aureus virulenceGreater body weightDevastating complicationClinical featuresAbscess formationLocal inflammationAggressive osteolysisLess osteolysisPreclinical modelsClinical utilization of species‐specific immunoassays for identification of Staphylococcus aureus and Streptococcus agalactiae in orthopedic infections
Sulovari A, Ninomiya MJ, Beck CA, Ricciardi BF, Ketonis C, Mesfin A, Kaplan NB, Soin SP, McDowell SM, Mahmood B, Daiss JL, Schwarz EM, Oh I. Clinical utilization of species‐specific immunoassays for identification of Staphylococcus aureus and Streptococcus agalactiae in orthopedic infections. Journal Of Orthopaedic Research® 2020, 39: 2141-2150. PMID: 33274775, PMCID: PMC8175449, DOI: 10.1002/jor.24935.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, BacterialArthritis, InfectiousHumansImmunoassayLeukocytes, MononuclearStaphylococcal InfectionsStaphylococcus aureusStreptococcus agalactiaeConceptsPeripheral blood mononuclear cellsFracture-related infectionMusculoskeletal infectionsOrthopedic infectionsHigh diagnostic potentialCultured peripheral blood mononuclear cellsDiagnostic potentialDeep musculoskeletal infectionSignificant patient morbidityBlood mononuclear cellsDiabetic foot ulcersAntigen-specific IgGPeriprosthetic joint infectionStaphylococcus aureusInfection patientsSeptic arthritisSurgical treatmentCurrent diagnostic methodsFoot ulcersJoint infectionAntibody titersMononuclear cellsPatient morbidityPolymicrobial infectionsAntibiotic use