2023
Transcriptomic identification of genes expressed in invasive S. aureus diabetic foot ulcer infection
Agidigbi T, Kwon H, Knight J, Zhao D, Lee F, Oh I. Transcriptomic identification of genes expressed in invasive S. aureus diabetic foot ulcer infection. Frontiers In Cellular And Infection Microbiology 2023, 13: 1198115. PMID: 37434783, PMCID: PMC10332306, DOI: 10.3389/fcimb.2023.1198115.Peer-Reviewed Original ResearchConceptsDiabetic foot ulcersPeripheral blood mononuclear cellsHost immune responseActive infectionImmune responseDiabetic foot ulcer infectionsInfected diabetic foot ulcersFoot ulcer infectionsPatients 8 weeksIntravenous antibiotic therapyBlood mononuclear cellsWound healing statusDFU infectionsPBMC expressionSalvage therapyUlcer infectionDifferent time pointsAntibiotic therapyMajor complicationsSurgical treatmentFoot ulcersMononuclear cellsPotential intervention optionsSpecies-specific infectionTreatment response
2022
Concurrent targeting of glycolysis in bacteria and host cell inflammation in septic arthritis
Kwon H, Yu K, Cahill S, Alder K, Dussik C, Kim S, Sharma L, Back J, Oh I, Lee F. Concurrent targeting of glycolysis in bacteria and host cell inflammation in septic arthritis. EMBO Molecular Medicine 2022, 14: emmm202115284. PMID: 36354099, PMCID: PMC9728052, DOI: 10.15252/emmm.202115284.Peer-Reviewed Original ResearchConceptsDrug dimethyl fumarateSeptic arthritisIntracellular MRSABacterial joint infectionSoft tissue infectionsAnti-inflammatory effectsInfection-associated inflammationNovel therapeutic paradigmContext of infectionConventional antibiotic treatmentHost cellsAdjuvant administrationSurgical treatmentTissue infectionsClinical symptomsInflammatory machineryJoint infectionBacterial burdenAntibiotic treatmentCell inflammationHost inflammationArthritisInflammationIntraarticular inflammationTherapeutic paradigm
2020
Clinical utilization of species‐specific immunoassays for identification of Staphylococcus aureus and Streptococcus agalactiae in orthopedic infections
Sulovari A, Ninomiya MJ, Beck CA, Ricciardi BF, Ketonis C, Mesfin A, Kaplan NB, Soin SP, McDowell SM, Mahmood B, Daiss JL, Schwarz EM, Oh I. Clinical utilization of species‐specific immunoassays for identification of Staphylococcus aureus and Streptococcus agalactiae in orthopedic infections. Journal Of Orthopaedic Research® 2020, 39: 2141-2150. PMID: 33274775, PMCID: PMC8175449, DOI: 10.1002/jor.24935.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsFracture-related infectionMusculoskeletal infectionsOrthopedic infectionsHigh diagnostic potentialCultured peripheral blood mononuclear cellsDiagnostic potentialDeep musculoskeletal infectionSignificant patient morbidityBlood mononuclear cellsDiabetic foot ulcersAntigen-specific IgGPeriprosthetic joint infectionStaphylococcus aureusInfection patientsSeptic arthritisSurgical treatmentCurrent diagnostic methodsFoot ulcersJoint infectionAntibody titersMononuclear cellsPatient morbidityPolymicrobial infectionsAntibiotic useSpecies-Specific Immunoassay for Diagnosis and Tracking Treatment Response in Foot and Ankle Infection
Oh I, Hao S, Waldman O, Holleran A, Daiss J. Species-Specific Immunoassay for Diagnosis and Tracking Treatment Response in Foot and Ankle Infection. Foot & Ankle Orthopaedics 2020, 5: 2473011420s00372. PMCID: PMC8702934, DOI: 10.1177/2473011420s00372.Peer-Reviewed Original ResearchAnkle infectionWound healing statusHealing statusDFU patientsOngoing infectionTreatment responseS. aureusDiabetic foot ulcer patientsFellowship-trained orthopedic footFoot ulcer patientsCharacteristic curve analysisDiagnostic toolSpecies-specific immunoassayReliable diagnostic toolOrthopaedic FootSpecific diagnostic toolsUlcer patientsAntibiotic therapyClinical resolutionSurgical treatmentClinical outcomesInitial presentationAntibody titersSerum antibodiesAnkle surgeonsGroup B Streptococcus Infected Tenosynovitis in Diabetic Foot Ulcers
Waldman O, Sajda T, Oh I, Sulovari A. Group B Streptococcus Infected Tenosynovitis in Diabetic Foot Ulcers. Foot & Ankle Orthopaedics 2020, 5: 2473011420s00483. PMCID: PMC8702881, DOI: 10.1177/2473011420s00483.Peer-Reviewed Original ResearchDiabetic foot ulcersPost-operative complicationsDFU patientsGBS patientsUnplanned readmissionInflammatory markersRay amputationAcute ulcersSurgical treatmentClinical outcomesFoot ulcersRepeat operationSevere soft tissue inflammationInfected diabetic foot ulcersSevere soft tissue damageElevated inflammatory markersHigh inflammatory markersAggressive surgical treatmentSoft tissue inflammationPost-surgical complicationsOrthopaedic surgeon's practiceGroup B streptococciSoft tissue damageBlood glucose valuesFrequent wound complications
2016
Surgical Anatomy of a Novel Medial Gastrocnemius Recession versus the Proximal Medial Gastrocnemius Recession
Oh I, DiGiovanni B, Kaplan N, Fowler X. Surgical Anatomy of a Novel Medial Gastrocnemius Recession versus the Proximal Medial Gastrocnemius Recession. Foot & Ankle Orthopaedics 2016, 1: 2473011416s00097. DOI: 10.1177/2473011416s00097.Peer-Reviewed Original ResearchMedial sural cutaneous nerveGastrocnemius recessionSmall saphenous veinGreat saphenous veinSaphenous veinSurgical marginsSemimembranosus tendonCutaneous nerveSaphenous nerveTibial nervePopliteal arteryGastrocnemius muscleNeurovascular structuresGreater riskAnatomic structuresEffective surgical treatmentMajor neurovascular structuresAttractive surgical optionWarrants further investigationStrayer procedureGastrocnemius contractureSurgical treatmentProximal releaseClinical efficacySurgical options