Adjuvant antibiotic‐loaded bone cement: Concerns with current use and research to make it work
Schwarz EM, McLaren AC, Sculco TP, Brause B, Bostrom M, Kates SL, Parvizi J, Alt V, Arnold WV, Carli A, Chen AF, Choe H, Coraça‐Huber D, Cross M, Ghert M, Hickok N, Jennings JA, Joshi M, Metsemakers W, Ninomiya M, Nishitani K, Oh I, Padgett D, Ricciardi B, Saeed K, Sendi P, Springer B, Stoodley P, Wenke JC, Workgroup H. Adjuvant antibiotic‐loaded bone cement: Concerns with current use and research to make it work. Journal Of Orthopaedic Research® 2020, 39: 227-239. PMID: 31997412, PMCID: PMC7390691, DOI: 10.1002/jor.24616.Peer-Reviewed Original ResearchConceptsAntibiotic-loaded bone cementMusculoskeletal infectionsLevel 1 evidenceRoutine laboratory testingMinimum biofilm eradication concentrationBone cementBiofilm eradication concentrationALBC useBiofilm-associated bacteriaOrthopedic infectionsClinical relevanceClinical practiceDrug AdministrationDrug susceptibilityLocal deliveryEradication concentrationInfectionAntibiotic resistanceCurrent useEfficacyVivo biofilmsLaboratory testingMicrobial colonizationPropose areasSubstantial lack