Featured Publications
Lupus nephritis and beyond: Kidney-intrinsic genetic risk for antibody deposition
Chernova I, Craft J. Lupus nephritis and beyond: Kidney-intrinsic genetic risk for antibody deposition. Cell Reports Medicine 2021, 2: 100479. PMID: 35028618, PMCID: PMC8714907, DOI: 10.1016/j.xcrm.2021.100479.Peer-Reviewed Original ResearchThe ion transporter Na+-K+-ATPase enables pathological B cell survival in the kidney microenvironment of lupus nephritis
Chernova I, Song W, Steach H, Hafez O, Al Souz J, Chen P, Chandra N, Cantley L, Veselits M, Clark M, Craft J. The ion transporter Na+-K+-ATPase enables pathological B cell survival in the kidney microenvironment of lupus nephritis. Science Advances 2023, 9: eadf8156. PMID: 36724234, PMCID: PMC9891690, DOI: 10.1126/sciadv.adf8156.Peer-Reviewed Original ResearchConceptsB cellsAutoimmune diseasesAmelioration of proteinuriaLupus nephritis biopsiesB cell infiltrationSodium-potassium adenosine triphosphataseB cell survivalPotassium adenosine triphosphataseLupus nephritisCell infiltrationKidney microenvironmentTissue injuryTherapeutic targetPharmacological inhibitionElevated sodium concentrationLupusHostile microenvironmentHigh expressionKidneySodium concentrationGenetic knockoutCell survivalDiseaseCellsAdenosine triphosphatase
2019
Resistant Hypertension Updated Guidelines
Chernova I, Krishnan N. Resistant Hypertension Updated Guidelines. Current Cardiology Reports 2019, 21: 117. PMID: 31471727, DOI: 10.1007/s11886-019-1209-6.BooksConceptsDiagnosis of RHOffice BP measurementsResistant hypertensionMedication optimizationBlood pressureBP measurementsAmerican Heart Association guidelinesUncontrolled blood pressureWhite-coat effectHeart Association guidelinesDevice-based interventionsPurpose of ReviewToLifestyle modificationMost patientsCoat effectInterventional therapyAssociation guidelinesDosing frequencySecondary causesHypertensionPatientsStep-wise approachDiagnosisFurther studiesTreatment
2007
TIM-1 and TIM-4 Glycoproteins Bind Phosphatidylserine and Mediate Uptake of Apoptotic Cells
Kobayashi N, Karisola P, Peña-Cruz V, Dorfman D, Jinushi M, Umetsu S, Butte M, Nagumo H, Chernova I, Zhu B, Sharpe A, Ito S, Dranoff G, Kaplan G, Casasnovas J, Umetsu D, DeKruyff R, Freeman G. TIM-1 and TIM-4 Glycoproteins Bind Phosphatidylserine and Mediate Uptake of Apoptotic Cells. Immunity 2007, 27: 927-940. PMID: 18082433, PMCID: PMC2757006, DOI: 10.1016/j.immuni.2007.11.011.Peer-Reviewed Original ResearchConceptsTIM-4TIM-1Apoptotic cellsT cell immunoglobulin mucin (TIM) proteinsPrevention of autoimmunityT cell activationGroup of receptorsDendritic cellsCell activationPeritoneal macrophagesMonoclonal antibodiesEfficient clearanceMouse macrophagesRecognition of phosphatidylserineMucin proteinKidney cellsPhagocytosisMacrophagesCellsPS bindingMediate uptakeAutoimmunityPhosphatidylserine
2001
PD-L2 is a second ligand for PD-1 and inhibits T cell activation
Latchman Y, Wood C, Chernova T, Chaudhary D, Borde M, Chernova I, Iwai Y, Long A, Brown J, Nunes R, Greenfield E, Bourque K, Boussiotis V, Carter L, Carreno B, Malenkovich N, Nishimura H, Okazaki T, Honjo T, Sharpe A, Freeman G. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nature Immunology 2001, 2: 261-268. PMID: 11224527, DOI: 10.1038/85330.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntigens, CDAntigens, SurfaceApoptosisApoptosis Regulatory ProteinsB7-1 AntigenB7-H1 AntigenBlood ProteinsCD28 AntigensCells, CulturedCHO CellsCricetinaeCytokinesHumansIntercellular Signaling Peptides and ProteinsJurkat CellsLigandsLymphocyte ActivationMembrane GlycoproteinsMiceMice, Inbred BALB CMolecular Sequence DataPeptidesProgrammed Cell Death 1 Ligand 2 ProteinProgrammed Cell Death 1 ReceptorReceptors, Antigen, T-CellSequence Homology, Amino AcidT-LymphocytesTransfectionConceptsPD-1 ligand 2PD-1 interactionPD-1PD-L1Cytokine productionAntigen concentrationPD-L expressionAutoimmune-like diseaseT cell responsesAntigen-presenting cellsT cell proliferationHigh antigen concentrationsT cell activationT cell receptorInterferon γ treatmentLow antigen concentrationsG0/G1Death-1Immunoinhibitory receptorCell cycle arrestDeficient miceT cellsCell activationΓ treatmentCell responses