2018
No strict requirement for eosinophils for bone marrow plasma cell survival
Bortnick A, Chernova I, Spencer SP, Allman D. No strict requirement for eosinophils for bone marrow plasma cell survival. European Journal Of Immunology 2018, 48: 815-821. PMID: 29442367, DOI: 10.1002/eji.201747229.Peer-Reviewed Original Research
2014
Lasting Antibody Responses Are Mediated by a Combination of Newly Formed and Established Bone Marrow Plasma Cells Drawn from Clonally Distinct Precursors
Chernova I, Jones DD, Wilmore JR, Bortnick A, Yucel M, Hershberg U, Allman D. Lasting Antibody Responses Are Mediated by a Combination of Newly Formed and Established Bone Marrow Plasma Cells Drawn from Clonally Distinct Precursors. The Journal Of Immunology 2014, 193: 4971-4979. PMID: 25326027, PMCID: PMC4234148, DOI: 10.4049/jimmunol.1401264.Peer-Reviewed Original ResearchConceptsBM plasma cellsPlasma cellsLong-term Ab responsesLong-term humoral responseBone marrow plasma cellsT cell-dependent AgSerum Ab titersIgG-secreting cellsRole of subpopulationsMarrow plasma cellsActivated B cellsPC poolAb titersHumoral responseAntibody responseIgG AbsAb responsesL chain usageIgM AbsB cellsHapten-protein conjugatesPC subsetsChain usageIgM
2007
TIM-1 and TIM-4 Glycoproteins Bind Phosphatidylserine and Mediate Uptake of Apoptotic Cells
Kobayashi N, Karisola P, Peña-Cruz V, Dorfman D, Jinushi M, Umetsu S, Butte M, Nagumo H, Chernova I, Zhu B, Sharpe A, Ito S, Dranoff G, Kaplan G, Casasnovas J, Umetsu D, DeKruyff R, Freeman G. TIM-1 and TIM-4 Glycoproteins Bind Phosphatidylserine and Mediate Uptake of Apoptotic Cells. Immunity 2007, 27: 927-940. PMID: 18082433, PMCID: PMC2757006, DOI: 10.1016/j.immuni.2007.11.011.Peer-Reviewed Original ResearchConceptsTIM-4TIM-1Apoptotic cellsT cell immunoglobulin mucin (TIM) proteinsPrevention of autoimmunityT cell activationGroup of receptorsDendritic cellsCell activationPeritoneal macrophagesMonoclonal antibodiesEfficient clearanceMouse macrophagesRecognition of phosphatidylserineMucin proteinKidney cellsPhagocytosisMacrophagesCellsPS bindingMediate uptakeAutoimmunityPhosphatidylserine
2001
PD-L2 is a second ligand for PD-1 and inhibits T cell activation
Latchman Y, Wood C, Chernova T, Chaudhary D, Borde M, Chernova I, Iwai Y, Long A, Brown J, Nunes R, Greenfield E, Bourque K, Boussiotis V, Carter L, Carreno B, Malenkovich N, Nishimura H, Okazaki T, Honjo T, Sharpe A, Freeman G. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nature Immunology 2001, 2: 261-268. PMID: 11224527, DOI: 10.1038/85330.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntigens, CDAntigens, SurfaceApoptosisApoptosis Regulatory ProteinsB7-1 AntigenB7-H1 AntigenBlood ProteinsCD28 AntigensCells, CulturedCHO CellsCricetinaeCytokinesHumansIntercellular Signaling Peptides and ProteinsJurkat CellsLigandsLymphocyte ActivationMembrane GlycoproteinsMiceMice, Inbred BALB CMolecular Sequence DataPeptidesProgrammed Cell Death 1 Ligand 2 ProteinProgrammed Cell Death 1 ReceptorReceptors, Antigen, T-CellSequence Homology, Amino AcidT-LymphocytesTransfectionConceptsPD-1 ligand 2PD-1 interactionPD-1PD-L1Cytokine productionAntigen concentrationPD-L expressionAutoimmune-like diseaseT cell responsesAntigen-presenting cellsT cell proliferationHigh antigen concentrationsT cell activationT cell receptorInterferon γ treatmentLow antigen concentrationsG0/G1Death-1Immunoinhibitory receptorCell cycle arrestDeficient miceT cellsCell activationΓ treatmentCell responses