2009
Regulating human Th17 cells via differential expression of IL-1 receptor
Lee WW, Kang SW, Choi J, Lee SH, Shah K, Eynon EE, Flavell RA, Kang I. Regulating human Th17 cells via differential expression of IL-1 receptor. Blood 2009, 115: 530-540. PMID: 19965648, PMCID: PMC2810985, DOI: 10.1182/blood-2009-08-236521.Peer-Reviewed Original ResearchConceptsT cellsIL-1RICell differentiationDifferential expressionIL-17IL-15IL-1betaIL-7T cell receptor triggeringT helper 17 (Th17) cellsIL-1 receptor expressionIL-1RI expressionIL-17 productionHelper 17 cellsT cell populationsCytokine IL-7IL-1R antagonistIL-1 receptorUmbilical cord bloodHuman peripheral bloodGene expressionReceptor triggeringPeripheral bloodCord bloodReceptor expression
2007
Dual Roles of IL-15 in Maintaining IL-7RαlowCCR7− Memory CD8+ T Cells in Humans via Recovering the Phosphatidylinositol 3-Kinase/AKT Pathway
Kim HR, Hwang KA, Kang I. Dual Roles of IL-15 in Maintaining IL-7RαlowCCR7− Memory CD8+ T Cells in Humans via Recovering the Phosphatidylinositol 3-Kinase/AKT Pathway. The Journal Of Immunology 2007, 179: 6734-6740. PMID: 17982063, DOI: 10.4049/jimmunol.179.10.6734.Peer-Reviewed Original ResearchMeSH KeywordsCD8-Positive T-LymphocytesCell ProliferationCell SurvivalEnzyme ActivationGene Expression RegulationHumansImmunologic MemoryInfectionsInterleukin-15Interleukin-2 Receptor beta SubunitInterleukin-7NeoplasmsPerforinPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktReceptors, Antigen, T-CellReceptors, CCR7Receptors, Interleukin-17Signal TransductionConceptsIL-15T cellsPI3K/Akt pathwayAkt pathwayIL-7Memory T cell survivalProliferation of ILIL-15 signalingHuman peripheral bloodT cell survivalEffector cytokinesMemory CD8Peripheral bloodEffector functionsIL-7REnhanced gene expressionProliferative functionIndependent mechanismsILTCR triggeringCell survivalSuch cellsSurvivalTranscriptional factorsDual roleDown-Regulation of IL-7Rα Expression in Human T Cells via DNA Methylation
Kim HR, Hwang KA, Kim KC, Kang I. Down-Regulation of IL-7Rα Expression in Human T Cells via DNA Methylation. The Journal Of Immunology 2007, 178: 5473-5479. PMID: 17442928, DOI: 10.4049/jimmunol.178.9.5473.Peer-Reviewed Original ResearchConceptsJurkat T cellsDNA methylationGene expressionGene promoterIL-7Ralpha expressionT cellsPromoter activityImportant gene regulatory mechanismGene regulatory mechanismsGene promoter constructsHuman CD8Gene promoter activityIL-7Cell survival responseT cell developmentT cell subsetsIL-7Rα expressionRegulatory mechanismsPromoter constructsCell developmentMethylationLuciferase reporterHuman T cellsSurvival responseDown regulation