2024
IL-1 receptor 1 signaling shapes the development of viral antigen-specific CD4+ T cell responses following COVID-19 mRNA vaccination
Park H, Shin M, Shin J, Kim H, Kang B, Par-Young J, Unlu S, Afinogenova Y, Catanzaro J, Young J, Kim M, Lee S, Jeon S, You S, Racke M, Bucala R, Kang I. IL-1 receptor 1 signaling shapes the development of viral antigen-specific CD4+ T cell responses following COVID-19 mRNA vaccination. EBioMedicine 2024, 103: 105114. PMID: 38640835, PMCID: PMC11041015, DOI: 10.1016/j.ebiom.2024.105114.Peer-Reviewed Original ResearchConceptsCD4<sup>+</sup> T cellsCOVID-19 mRNA vaccinesAntigen-specific CD4<sup>+</sup> T cell responsesT cell responsesPrimary antibody deficiencyCD4<sup>+</sup> T cell responsesT cellsIL-1R1MRNA vaccinesIL-1IgG antibodiesAntigen-specific CD4<sup>+</sup> T cellsCD4+ T cell responsesLevels of IL-1R1Human CD4<sup>+</sup> T cellsIL-1 receptor 1Healthy individualsDose of COVID-19 mRNA vaccineAntigen-specific CD4IL-1R1 expressionT cell immunityRepetitive antigenic stimulationCytokines interleukin (IL)-1Immune response to virusesExpression of IL-1R1
2009
Regulating human Th17 cells via differential expression of IL-1 receptor
Lee WW, Kang SW, Choi J, Lee SH, Shah K, Eynon EE, Flavell RA, Kang I. Regulating human Th17 cells via differential expression of IL-1 receptor. Blood 2009, 115: 530-540. PMID: 19965648, PMCID: PMC2810985, DOI: 10.1182/blood-2009-08-236521.Peer-Reviewed Original ResearchConceptsT cellsIL-1RICell differentiationDifferential expressionIL-17IL-15IL-1betaIL-7T cell receptor triggeringT helper 17 (Th17) cellsIL-1 receptor expressionIL-1RI expressionIL-17 productionHelper 17 cellsT cell populationsCytokine IL-7IL-1R antagonistIL-1 receptorUmbilical cord bloodHuman peripheral bloodGene expressionReceptor triggeringPeripheral bloodCord bloodReceptor expression
2001
CD4+ T Helper 1 Cells Facilitate Regression of Murine Lyme Carditis
Bockenstedt L, Kang I, Chang C, Persing D, Hayday A, Barthold S. CD4+ T Helper 1 Cells Facilitate Regression of Murine Lyme Carditis. Infection And Immunity 2001, 69: 5264-5269. PMID: 11500394, PMCID: PMC98634, DOI: 10.1128/iai.69.9.5264-5269.2001.Peer-Reviewed Original ResearchConceptsAlphabeta T-cell-deficient miceT cell-deficient miceMurine Lyme carditisT cellsLyme carditisB cellsT helper 1 cellsAnti-inflammatory cytokines mRNA levelsTumor necrosis factor alphaBurgdorferi-specific antibodiesInfected control miceProminent macrophage infiltrateCell-mediated immunityT cell responsesT helper 1Murine Lyme borreliosisCytokine mRNA levelsNecrosis factor alphaAlphabeta T cellsPrincipal immune cellsMouse strain backgroundAdoptive transferAcute arthritisMacrophage infiltratesControl mice
2000
Modulation of collagen-induced arthritis by IL-4 and dexamethasone: the synergistic effect of IL-4 and dexamethasone on the resolution of CIA
Kang I, Lee W, Lee Y. Modulation of collagen-induced arthritis by IL-4 and dexamethasone: the synergistic effect of IL-4 and dexamethasone on the resolution of CIA. Immunopharmacology 2000, 49: 317-324. PMID: 10996029, DOI: 10.1016/s0162-3109(00)00248-4.Peer-Reviewed Original Research
1998
Modulation of Murine Lyme Borreliosis by Interruption of the B7/CD28 T-Cell Costimulatory Pathway
Shanafelt M, Kang I, Barthold S, Bockenstedt L. Modulation of Murine Lyme Borreliosis by Interruption of the B7/CD28 T-Cell Costimulatory Pathway. Infection And Immunity 1998, 66: 266-271. PMID: 9423867, PMCID: PMC107886, DOI: 10.1128/iai.66.1.266-271.1998.Peer-Reviewed Original ResearchAbataceptAnimalsAntibodies, BacterialAntibodies, BlockingAntigens, CDAntigens, DifferentiationArthritis, InfectiousB7-1 AntigenB7-2 AntigenCD28 AntigensCTLA-4 AntigenFemaleImmunoconjugatesImmunoglobulin GInterferon-gammaInterleukin-4Lyme DiseaseLymphocyte ActivationMembrane GlycoproteinsMiceMice, Inbred BALB CSpecific Pathogen-Free OrganismsTh1 CellsTh2 CellsUp-Regulation