Inmaculada Ruz-Maldonado
Associate Research ScientistCards
About
Research
Publications
2024
Global deletion of G protein‐coupled receptor 55 impairs glucose homeostasis during obesity by reducing insulin secretion and β‐cell turnover
Liu B, Ruz‐Maldonado I, Persaud S. Global deletion of G protein‐coupled receptor 55 impairs glucose homeostasis during obesity by reducing insulin secretion and β‐cell turnover. Diabetes Obesity And Metabolism 2024, 26: 4591-4601. PMID: 39113250, DOI: 10.1111/dom.15816.Peer-Reviewed Original ResearchGPR55<sup>-/-</sup> miceDiet-induced obesityIncreased islet cell apoptosisHigh-fat dietB cell proliferationWild-typeCytokine-induced apoptosisInsulin secretionCaspase-3/7 activityIslet cell apoptosisGlucose homeostasisInsulin secretion in vivoWT miceB cellsDynamic insulin secretionImpaired glucose-Standard chowSusceptibility to diet-induced obesityPerifusion of isolated isletsIslet functionG protein-coupled receptorsG protein-coupled receptor 55Weeks of dietary interventionReduced insulin secretionB cell turnoverFatty acid binding protein 5 suppression attenuates obesity-induced hepatocellular carcinoma by promoting ferroptosis and intratumoral immune rewiring
Sun J, Esplugues E, Bort A, Cardelo M, Ruz-Maldonado I, Fernández-Tussy P, Wong C, Wang H, Ojima I, Kaczocha M, Perry R, Suárez Y, Fernández-Hernando C. Fatty acid binding protein 5 suppression attenuates obesity-induced hepatocellular carcinoma by promoting ferroptosis and intratumoral immune rewiring. Nature Metabolism 2024, 6: 741-763. PMID: 38664583, DOI: 10.1038/s42255-024-01019-6.Peer-Reviewed Original ResearchConceptsFatty acid binding protein 5Tumor-associated macrophagesHepatocellular carcinomaImmunosuppressive phenotype of tumor-associated macrophagesIncreased CD8+ T cell activationCD8+ T cell activationPhenotype of tumor-associated macrophagesPro-inflammatory tumor microenvironmentCo-stimulatory molecules CD80T cell activationHepatocellular carcinoma burdenTransformation of hepatocytesBinding protein 5Potential therapeutic approachImmunosuppressive phenotypeTumor microenvironmentFerroptosis-induced cell deathMale miceEnhanced ferroptosisTherapeutic approachesPharmacological inhibitionGenetic ablationIncreased expressionSingle-cell atlasAnalysis of transformed cellsHeterogeneity of hepatocyte dynamics restores liver architecture after chemical, physical or viral damage
Ruz-Maldonado I, Gonzalez J, Zhang H, Sun J, Bort A, Kabir I, Kibbey R, Suárez Y, Greif D, Fernández-Hernando C. Heterogeneity of hepatocyte dynamics restores liver architecture after chemical, physical or viral damage. Nature Communications 2024, 15: 1247. PMID: 38341404, PMCID: PMC10858916, DOI: 10.1038/s41467-024-45439-0.Peer-Reviewed Original Research
2023
Kisspeptin upregulates β-cell serotonin production during pregnancy
Hill T, Smith L, Ruz-Maldonado I, Jones P, Bowe J. Kisspeptin upregulates β-cell serotonin production during pregnancy. Journal Of Endocrinology 2023, 260: e230218. PMID: 37997938, PMCID: PMC10762540, DOI: 10.1530/joe-23-0218.Peer-Reviewed Original ResearchConceptsIslet adaptationSerotonin productionSerotonin biosynthesisΒ-cellsDevelopment of GDMEffects of kisspeptinLactogenic hormonesGestational insulin resistanceΒ-cell compensationElevated insulin secretionMaternal pancreatic isletsΒ-cell proliferationPregnant controlsInsulin resistanceSerotonin levelsInsulin secretionAutocrine effectsPregnancyTPH-1KisspeptinKnockdown micePancreatic isletsRodent isletsPro-proliferative genesTime points