2024
To Expose or Not to Expose: A Comprehensive Perspective on Treatment for Posttraumatic Stress Disorder
Rubenstein A, Duek O, Doran J, Harpaz-Rotem I. To Expose or Not to Expose: A Comprehensive Perspective on Treatment for Posttraumatic Stress Disorder. American Psychologist 2024, 79: 331-343. PMID: 38635195, PMCID: PMC11034887, DOI: 10.1037/amp0001121.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderTreating posttraumatic stress disorderNon-trauma-focused treatmentsExposure therapyStress disorderTreatment of posttraumatic stress disorderNon-trauma-focused therapiesPosttraumatic stress disorder diagnosisSelf-directed exposureTrauma-focused psychotherapyPsychotherapy factorsTrauma memoriesTrauma-focusedBehavioral paradigmsSymptom remissionHigh dropout ratesTherapy processTherapy contextProlonged exposurePsychotherapyDropout ratesIncreased patient autonomyResearch literatureDisordersClinical research
2023
Long term structural and functional neural changes following a single infusion of Ketamine in PTSD
Duek O, Korem N, Li Y, Kelmendi B, Amen S, Gordon C, Milne M, Krystal J, Levy I, Harpaz-Rotem I. Long term structural and functional neural changes following a single infusion of Ketamine in PTSD. Neuropsychopharmacology 2023, 48: 1648-1658. PMID: 37270621, PMCID: PMC10517133, DOI: 10.1038/s41386-023-01606-3.Peer-Reviewed Original ResearchConceptsKetamine recipientsSingle infusionMain study outcomeTiming of administrationEnd of treatmentNMDA receptor antagonistFunctional neural changesFrequency of administrationSignificant clinical implicationsTrauma-focused psychotherapyBrief exposure therapyAmygdala-vmPFC connectivityPost-retrieval extinctionKetamine doseKetamine administrationReceptor antagonistTrauma scriptsNeural changesClinical implicationsDecreased connectivityExposure therapyKetamineTrauma memoriesStudy outcomesUncinate fasciculus
2020
Courses of suicidal ideation among military veterans in residential treatment for posttraumatic stress disorder
Smith NB, Sippel LM, Rozek DC, Spangler PT, Traber D, Straud CL, Hoff R, Harpaz‐Rotem I. Courses of suicidal ideation among military veterans in residential treatment for posttraumatic stress disorder. Depression And Anxiety 2020, 37: 273-284. PMID: 31951318, PMCID: PMC7054126, DOI: 10.1002/da.22993.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderBaseline posttraumatic stress disorderPTSD treatmentResidential PTSD treatmentPhysical functioningSuicidal thoughtsStress disorderPTSD symptomsSubstance useVeterans Affairs medical facilitiesWorse physical functioningLength of stayPTSD symptom improvementTrauma-focused psychotherapySpecific treatment interventionsPTSD symptom changeSeverity of suicidalSI onsetRace/ethnicitySymptom improvementPTSD improvementBaseline depressionMultinomial logistic regressionTreatment interventionsSuicidal ideation
2019
Predictors of Dropout From Residential Treatment for Posttraumatic Stress Disorder Among Military Veterans
Smith NB, Sippel LM, Rozek DC, Hoff RA, Harpaz-Rotem I. Predictors of Dropout From Residential Treatment for Posttraumatic Stress Disorder Among Military Veterans. Frontiers In Psychology 2019, 10: 362. PMID: 30873081, PMCID: PMC6401625, DOI: 10.3389/fpsyg.2019.00362.Peer-Reviewed Original ResearchPosttraumatic stress disorderTreatment dropoutResidential treatmentStress disorderSymptomatic patient populationResidential PTSD programsType of treatmentTrauma-focused psychotherapyVeterans Affairs programsTrauma-focused therapyResidential programsResidential PTSD treatmentPredictors of dropoutPatient populationSuccessful treatmentPhysical functioningSymptomatic individualsPsychiatric symptomsHigh riskPTSD treatmentReduced likelihoodFiscal year 2015PTSD programGreater PTSD symptomsGreater symptoms