Association Between Left Ventricular Mechanical Deformation and Myocardial Fibrosis in Nonischemic Cardiomyopathy
Csecs I, Pashakhanloo F, Paskavitz A, Jang J, Al‐Otaibi T, Neisius U, Manning W, Nezafat R. Association Between Left Ventricular Mechanical Deformation and Myocardial Fibrosis in Nonischemic Cardiomyopathy. Journal Of The American Heart Association 2020, 9: e016797. PMID: 33006296, PMCID: PMC7792406, DOI: 10.1161/jaha.120.016797.Peer-Reviewed Original ResearchMeSH KeywordsCardiomyopathiesFemaleFibrosisHeartHumansMagnetic Resonance ImagingMaleMiddle AgedMyocardiumRetrospective StudiesStroke VolumeVentricular RemodelingConceptsLate gadolinium enhancementSeptal late gadolinium enhancementLV ejection fractionNonischemic cardiomyopathyExtent of fibrosisCardiovascular magnetic resonanceEjection fractionImpaired global circumferential strainImpaired LV ejection fractionLate gadolinium enhancement groupsDepressed LV ejection fractionClinical cardiovascular magnetic resonanceLeft ventricular (LVLGE-negative groupCircumferential strainGlobal radial strainGlobal longitudinal strainRadial strainGlobal circumferential strainLV deformation parametersGlobal LV functionAdverse cardiovascular outcomesLGE-positiveNonischemic fibrosisFibrosis burdenMulti‐domain convolutional neural network (MD‐CNN) for radial reconstruction of dynamic cardiac MRI
El‐Rewaidy H, Fahmy A, Pashakhanloo F, Cai X, Kucukseymen S, Csecs I, Neisius U, Haji‐Valizadeh H, Menze B, Nezafat R. Multi‐domain convolutional neural network (MD‐CNN) for radial reconstruction of dynamic cardiac MRI. Magnetic Resonance In Medicine 2020, 85: 1195-1208. PMID: 32924188, DOI: 10.1002/mrm.28485.Peer-Reviewed Original ResearchConceptsStructural similarity indexMulti-domain convolutional neural networkMean-squared-errorConvolutional neural networkMD-CNNNeural networkDynamic cardiac MRIComplex-valued networksCardiac MR cine imagesK-space interpolationProcessing MR dataImage domainTemporal fidelityUndersampled datasetsFast reconstructionCine imagesK-spaceArtifact suppressionMR cine imagesSimilarity indexCine dataBorder sharpnessNetworkLong scan timesNon-sinus rhythmLeft atrial fibrosis progression detected by LGE‐MRI after ablation of atrial fibrillation
Kheirkhahan M, Baher A, Goldooz M, Kholmovski E, Morris A, Csecs I, Chelu M, Wilson B, Marrouche N. Left atrial fibrosis progression detected by LGE‐MRI after ablation of atrial fibrillation. Pacing And Clinical Electrophysiology 2020, 43: 402-411. PMID: 31867751, DOI: 10.1111/pace.13866.Peer-Reviewed Original ResearchConceptsAF recurrenceAF ablationLGE-MRIAtrial fibrillationLong-term procedural outcomesGadolinium-enhanced magnetic resonance imagingAssociated with significantly higher riskArrhythmia-free survivalAtrial arrhythmia recurrencePostablation AF recurrenceLate gadolinium enhancement magnetic resonance imagingEnhanced magnetic resonance imagingFollow-up periodSignificantly higher riskCardiovascular risk factorsMagnetic resonance imagingMonths postablationArrhythmia recurrenceConsecutive patientsLA fibrosisAblation proceduresFibrosis progressionProcedural outcomesAblation lesionsRecurrence