2022
An Explainable Machine Learning Approach Reveals Prognostic Significance of Right Ventricular Dysfunction in Nonischemic Cardiomyopathy
Fahmy A, Csecs I, Arafati A, Assana S, Yankama T, Al-Otaibi T, Rodriguez J, Chen Y, Ngo L, Manning W, Kwong R, Nezafat R. An Explainable Machine Learning Approach Reveals Prognostic Significance of Right Ventricular Dysfunction in Nonischemic Cardiomyopathy. JACC Cardiovascular Imaging 2022, 15: 766-779. PMID: 35033500, DOI: 10.1016/j.jcmg.2021.11.029.Peer-Reviewed Original ResearchConceptsNonischemic dilated cardiomyopathyBeth Israel Deaconess Medical CenterComposite endpointRight ventricular (RV) dysfunctionCardiovascular hospitalizationRisk prediction modelAdverse outcomesRisk markersMarker of adverse outcomeCardiac magnetic resonance markersRisk stratification of patientsRight ventricular dysfunctionRV ejection fractionMedical CenterFollow-up durationCardiac magnetic resonanceEnd-diastolic volumeStratification of patientsArea under the curveAll-cause deathHigh-risk thresholdVentricular dysfunctionEjection fractionNonischemic cardiomyopathyPrognostic significance
2020
Association Between Left Ventricular Mechanical Deformation and Myocardial Fibrosis in Nonischemic Cardiomyopathy
Csecs I, Pashakhanloo F, Paskavitz A, Jang J, Al‐Otaibi T, Neisius U, Manning W, Nezafat R. Association Between Left Ventricular Mechanical Deformation and Myocardial Fibrosis in Nonischemic Cardiomyopathy. Journal Of The American Heart Association 2020, 9: e016797. PMID: 33006296, PMCID: PMC7792406, DOI: 10.1161/jaha.120.016797.Peer-Reviewed Original ResearchConceptsLate gadolinium enhancementSeptal late gadolinium enhancementLV ejection fractionNonischemic cardiomyopathyExtent of fibrosisCardiovascular magnetic resonanceEjection fractionImpaired global circumferential strainImpaired LV ejection fractionLate gadolinium enhancement groupsDepressed LV ejection fractionClinical cardiovascular magnetic resonanceLeft ventricular (LVLGE-negative groupCircumferential strainGlobal radial strainGlobal longitudinal strainRadial strainGlobal circumferential strainLV deformation parametersGlobal LV functionAdverse cardiovascular outcomesLGE-positiveNonischemic fibrosisFibrosis burdenHow are ECG parameters related to cardiac magnetic resonance images? Electrocardiographic predictors of left ventricular hypertrophy and myocardial fibrosis in hypertrophic cardiomyopathy
Dohy Z, Vereckei A, Horvath V, Czimbalmos C, Szabo L, Toth A, Suhai F, Csecs I, Becker D, Merkely B, Vago H. How are ECG parameters related to cardiac magnetic resonance images? Electrocardiographic predictors of left ventricular hypertrophy and myocardial fibrosis in hypertrophic cardiomyopathy. Annals Of Noninvasive Electrocardiology 2020, 25: e12763. PMID: 32329134, PMCID: PMC7507346, DOI: 10.1111/anec.12763.Peer-Reviewed Original ResearchConceptsRomhilt-Estes scoreLeft ventricular hypertrophyCardiac magnetic resonance imagingFragmented QRSSokolow-Lyon indexHypertrophic cardiomyopathyMyocardial fibrosisCornell indexMagnetic resonance imagingVentricular hypertrophyRepolarization abnormalitiesPredictor of myocardial fibrosisElectrocardiographic parametersPresence of fragmented QRSLeft ventricular ejection fractionDetectable left ventricular hypertrophyElectrocardiographic voltage criteriaResonance imagingVentricular ejection fractionHypertrophic cardiomyopathy patientsStructural myocardial changesDegree of myocardial fibrosisPathologic Q wavesAmount of fibrosisEjection fraction
2019
P310Differentiation between arrhythmogenic right ventricular cardiomyopathy and athlete's heart using cardiac magnetic resonance based derived parameters and strain analysis
Czimbalmos C, Csecs I, Dohy Z, Toth A, Suhai F, Szabo L, Kiss O, Sydo N, Kovacs A, Lakatos B, Merkely B, Vago H. P310Differentiation between arrhythmogenic right ventricular cardiomyopathy and athlete's heart using cardiac magnetic resonance based derived parameters and strain analysis. European Heart Journal 2019, 40: ehz747.0145. DOI: 10.1093/eurheartj/ehz747.0145.Peer-Reviewed Original ResearchArrhythmogenic right ventricular cardiomyopathyArrhythmogenic right ventricular cardiomyopathy patientsTask Force criteriaRight ventricular cardiomyopathyCMR parametersARVC patientsEjection fractionVentricular cardiomyopathyDiagnostic accuracyRevised task force criteriaAthlete's heartForce criteriaDiagnosing ARVCRegional strain valuesRV global strainRV strain parametersEnd-diastolic volume ratioRight ventricular end-systolicGlobal circumferential strainRV strain rateCardiac magnetic resonanceStroke volume indexVentricular end-systolicT-wave inversionCut-off valueP4429Cardiac magnetic resonance characteristics of professional athletes and hypertrophic cardiomyopathy patients in the grey zone of hypertrophy
Czimbalmos C, Csecs I, Dohy Z, Toth A, Suhai F, Szabo L, Horvath V, Sydo N, Kiss O, Becker D, Merkely B, Vago H. P4429Cardiac magnetic resonance characteristics of professional athletes and hypertrophic cardiomyopathy patients in the grey zone of hypertrophy. European Heart Journal 2019, 40: ehz745.0831. DOI: 10.1093/eurheartj/ehz745.0831.Peer-Reviewed Original ResearchMale HCM patientsHCM patientsHypertrophic cardiomyopathy patientsHypertrophic cardiomyopathyHealthy athletesEjection fractionLeft ventricular (LV) ejection fractionLV) ejection fractionConventional CMR parametersCardiac magnetic resonanceEnd-diastolic wall thicknessLV hypertrophyCardiomyopathy patientsNo significant differenceCMR parametersGray zoneHCM groupEnd-diastolicPhysiological hypertrophyPatient groupAthlete's heartEnd-systolePatientsHypertrophyStroke volume
2018
Cardiac magnetic resonance based deformation imaging: role of feature tracking in athletes with suspected arrhythmogenic right ventricular cardiomyopathy
Czimbalmos C, Csecs I, Dohy Z, Toth A, Suhai F, Müssigbrodt A, Kiss O, Geller L, Merkely B, Vago H. Cardiac magnetic resonance based deformation imaging: role of feature tracking in athletes with suspected arrhythmogenic right ventricular cardiomyopathy. The International Journal Of Cardiovascular Imaging 2018, 35: 529-538. PMID: 30382474, PMCID: PMC6453871, DOI: 10.1007/s10554-018-1478-y.Peer-Reviewed Original ResearchMeSH KeywordsAdultArrhythmogenic Right Ventricular DysplasiaAthletesCardiomegaly, Exercise-InducedCase-Control StudiesDiagnosis, DifferentialFemaleHeart VentriclesHumansImage Interpretation, Computer-AssistedMagnetic Resonance Imaging, CineMaleMyocardial ContractionPredictive Value of TestsReproducibility of ResultsStroke VolumeVentricular Function, LeftVentricular Function, RightVentricular RemodelingConceptsArrhythmogenic right ventricular cardiomyopathyRV ejection fractionCardiac magnetic resonanceTask Force criteriaRV free wallRight ventricular cardiomyopathyCut-off valueAthlete's heartVentricular cardiomyopathyBalanced steady-state free precession cine imagesRight ventricular (RV) remodelingSuspected arrhythmogenic right ventricular cardiomyopathyDiagnosis of arrhythmogenic right ventricular cardiomyopathySteady-state free precession cine imagesFree wallHealthy athletesRV strain analysisRight ventricular volumesRV dilatationEjection fractionCine imagesVentricular volumeRegional strain analysisTrained athletesMagnetic resonanceLeft and right ventricular parameters corrected with threshold-based quantification method in a normal cohort analyzed by three independent observers with various training-degree
Csecs I, Czimbalmos C, Suhai F, Mikle R, Mirzahosseini A, Dohy Z, Szűcs A, Kiss A, Simor T, Tóth A, Merkely B, Vágó H. Left and right ventricular parameters corrected with threshold-based quantification method in a normal cohort analyzed by three independent observers with various training-degree. The International Journal Of Cardiovascular Imaging 2018, 34: 1127-1133. PMID: 29492774, DOI: 10.1007/s10554-018-1322-4.Peer-Reviewed Original ResearchConceptsCardiac magnetic resonancePapillary musclesInterobserver agreementIndependent observersShort-axis cine imagesCardiac magnetic resonance scansRight ventricular parametersRV ejection fractionRight ventricular functionInvestigate interobserver variabilityGlobal intraclass correlation coefficientAssess LVIntraclass correlation coefficientRV parametersEjection fractionVentricular parametersVentricular functionHealthy volunteersCine imagesLV parametersEnd-diastolicInterobserver variabilityMeasure LVEnd-systoleTB method