1987
The Biochemistry of Fetal Lung Development
Kresch M, Gross I. The Biochemistry of Fetal Lung Development. Clinics In Perinatology 1987, 14: 481-507. PMID: 3311536, DOI: 10.1016/s0095-5108(18)30747-4.ChaptersConceptsSurfactant therapyLung complianceLung maturationAdministration of betamethasoneEffects of glucocorticoidsFetal lung developmentNumber of alveoliGlucocorticoid therapyFetal rabbitsLung developmentTherapyAnimal dataTissue complianceHormonal enhancementAdditive effectAdministrationComplianceMaturationRDSMorbidityBetamethasoneGlucocorticoidsLungMortalitySteroids
1979
Thyrotropin-Releasing Hormone Increases the Amount of Surfactant in Lung Lavage from Fetal Rabbits
Rooney S, Marino P, Gobran L, Gross I, Warshaw J. Thyrotropin-Releasing Hormone Increases the Amount of Surfactant in Lung Lavage from Fetal Rabbits. Pediatric Research 1979, 13: 623-625. PMID: 112569, DOI: 10.1203/00006450-197905000-00009.Peer-Reviewed Original ResearchConceptsThyrotropin-releasing hormoneLung lavageLung maturationFetal lung slicesRespiratory distress syndromeFetal lung maturationPulmonary surfactant productionSurfactant productionPhosphatidylcholine/sphingomyelin ratioDistress syndromeTRH administrationPregnant rabbitsIncorporation of cholineFetal rabbitsGestation resultsLung slicesLavagePhysiologic roleFetusesSphingomyelin ratioTotal phospholipidsControl littersSurfactant releasePhospholipid contentMore phosphatidylcholine
1977
AMINOPHYLLINE STIMULATES PHOSPHOLIPID SYNTHESIS BY FETAL RAT LUNG IN ORGAN CULTURE
Gross I, Rooney S, Warshaw J. AMINOPHYLLINE STIMULATES PHOSPHOLIPID SYNTHESIS BY FETAL RAT LUNG IN ORGAN CULTURE. Pediatric Research 1977, 11: 571-571. DOI: 10.1203/00006450-197704000-01210.Peer-Reviewed Original ResearchFetal rat lungRat lungInfluence of aminophyllineAdministration of aminophyllineOrgan cultureLung phospholipid synthesisCyclic AMPAminophylline effectsDays lungsDibutyryl cyclic AMPNonspecific stimulationLES stimulationIncorporation of cholineMM aminophyllineFetal rabbitsPhospholipid synthesisAminophyllineProtein/hourLungDay fetusesSignificant increaseF12 mediumSph synthesisStimulationExposure
1976
Studies on pulmonary surfactant Effects of cortisol administration to fetal rabbits on lung phospholipid content, composition and biosynthesis
Rooney S, Gobran L, Gross I, Wai-Lee T, Nardone L, Motoyama E. Studies on pulmonary surfactant Effects of cortisol administration to fetal rabbits on lung phospholipid content, composition and biosynthesis. Biochimica Et Biophysica Acta 1976, 450: 121-130. PMID: 186118, DOI: 10.1016/0005-2760(76)90083-7.Peer-Reviewed Original ResearchMeSH Keywords1-Acylglycerophosphocholine O-AcyltransferaseAnimalsCholine KinaseCytidine Diphosphate CholineDiacylglycerol CholinephosphotransferaseFatty AcidsFemaleFetusGestational AgeGlycerolHydrocortisoneLungNucleotidyltransferasesPhosphatidylcholinesPhospholipidsPregnancyPulmonary SurfactantsRabbitsConceptsLung lavageCortisol administrationDays gestationFetal rabbitsUntreated fetusesLung phospholipid contentGreater gestational ageSaline-injected controlsLysolecithin acyltransferasePhospholipid contentGestational ageIntrauterine injectionLung tissueSaline injectionFetal lungMaturational effectsGestationFetusesLavageMajor surface-active componentAdministrationCorticosteroidsCholinephosphate cytidylyltransferaseSynthesis of phosphatidylcholineHormone
1975
The Influence of Cortisol on the Enzymes of Fatty Acid Synthesis in Developing Mammalian Lung and Brain
Gross I, Rooney S, Warshaw J. The Influence of Cortisol on the Enzymes of Fatty Acid Synthesis in Developing Mammalian Lung and Brain. Pediatric Research 1975, 9: 752-755. PMID: 648, DOI: 10.1203/00006450-197509000-00014.Peer-Reviewed Original ResearchConceptsDe novo fatty acid synthesisNovo fatty acid synthesisFatty acid synthesisRabbit lungsFatty acid synthetaseAcetyl-CoA carboxylase activityAccelerated lung maturationCortisol-induced inhibitionHyaline membrane diseaseAdministration of cortisolFetal rabbit lungInfluence of cortisolFatty acid synthetase activityAcid synthesisFatty acid elongation activityAntenatal administrationNumber of inhibitoryMembrane diseaseRight lungLung maturationLung growthCortisol exposureElectron microscopic examinationFetal rabbitsFetal brainStimulation of glycerolphosphate phosphatidyltransferase activity in fetal rabbit lung by cortisol administration
Rooney S, Gross I, Gassenheimer L, Motoyama E. Stimulation of glycerolphosphate phosphatidyltransferase activity in fetal rabbit lung by cortisol administration. Biochimica Et Biophysica Acta 1975, 398: 433-441. PMID: 1242106, DOI: 10.1016/0005-2760(75)90194-0.Peer-Reviewed Original ResearchConceptsAdministration of cortisolFetal rabbit lungLysolecithin acyltransferase activityLung maturationLiver enzymesDays gestationFetal rabbitsThyroxine treatmentGestation resultsCortisol administrationRabbit lungsCortisol treatmentDirect administrationAdministrationPulmonary surfactantSurfactant productionSignificant increaseGestationCholine phosphotransferaseAcyltransferase activityTreatmentCorticosteroidsPrevious studiesLungFetuses
1974
Enzyme Activities Related to Fatty Acid Synthesis in Developing Mammalian Lung
Gross I, Warshaw J. Enzyme Activities Related to Fatty Acid Synthesis in Developing Mammalian Lung. Pediatric Research 1974, 8: 193-199. PMID: 4150151, DOI: 10.1203/00006450-197403000-00007.Peer-Reviewed Original ResearchConceptsDe novo fatty acid synthesisNovo fatty acid synthesisFetal lifeFatty acid synthesisRabbit lungsHepatic de novo fatty acid synthesisEarly dietary intakeHepatic fatty acid synthesisFatty acidsFetal rabbit lungAcid synthesisDe novo pathwaySurface-active lipidsPulmonary synthesisFatty acid elongationLung homogenatesDietary intakeNutritional intakeFetal rabbitsMicrosomal fatty acid elongationRabbit fetusesLipid metabolismLung membranesLungAdult levels