2019
A novel copy number variation in CATSPER2 causes idiopathic male infertility with normal semen parameters
Luo T, Chen H, Zou Q, Wang T, Cheng Y, Wang H, Wang F, Jin Z, Chen Y, Weng S, Zeng X. A novel copy number variation in CATSPER2 causes idiopathic male infertility with normal semen parameters. Human Reproduction 2019, 34: 414-423. PMID: 30629171, DOI: 10.1093/humrep/dey377.Peer-Reviewed Original ResearchConceptsIdiopathic male infertilityNormal semen parametersWhole-cell patch-clamp techniqueMale infertilityPatch-clamp techniqueSemen parametersCatSper currentsIdiopathic infertilitySTUDY FUNDING/COMPETINGGenetic abnormalitiesCatSper genesChild Health HospitalReproductive medical centerNovel copy number variationsPARTICIPANTS/MATERIALSROLE OF CHANCEHuman male infertilityHealthy male donorsCopy number variationsHuman CatSperPrinciple Ca2Progesterone responseCase reportProvincial MaternalHealth Hospital
2017
Exposure to Cadmium Impairs Sperm Functions by Reducing CatSper in Mice
Wang H, Chang M, Peng T, Yang Y, Li N, Luo T, Cheng Y, Zhou M, Zeng X, Zheng L. Exposure to Cadmium Impairs Sperm Functions by Reducing CatSper in Mice. Cellular Physiology And Biochemistry 2017, 42: 44-54. PMID: 28554186, DOI: 10.1159/000477113.Peer-Reviewed Original ResearchConceptsAdult male C57BL/6 miceMale C57BL/6 miceImpair sperm functionAcute cadmium exposureSperm functionSperm-specific Ca2C57BL/6 miceReproductive toxicityCadmium exposureWestern blottingDifferent dosesSperm dysfunctionExpression levelsEnvironmental heavy metalsToxic effectsMiceEndocrine disruptorsCatSperSperm motilityMouse spermatozoaSpecific roleToxicityExposureMotilityDysfunction
2015
Matrine Inhibits Mouse Sperm Function by Reducing Sperm [Ca2+]i and Phospho-ERK1/2
Luo T, Zou Q, He Y, Wang H, Li N, Zeng X. Matrine Inhibits Mouse Sperm Function by Reducing Sperm [Ca2+]i and Phospho-ERK1/2. Cellular Physiology And Biochemistry 2015, 35: 374-385. PMID: 25591778, DOI: 10.1159/000369703.Peer-Reviewed Original ResearchMeSH KeywordsAcrosome ReactionAlkaloidsAniline CompoundsAnimalsCalcimycinCalciumFemaleFertilization in VitroMaleMatrinesMiceMice, Inbred C57BLMicroscopy, FluorescenceMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Patch-Clamp TechniquesPhosphorylationPotassiumQuinolizinesSperm MotilitySpermatozoaXanthenesConceptsMouse sperm functionIntracellular calcium concentrationSperm functionCauda epididymal spermMouse spermPhosphorylation of ERK1/2Acrosome reaction rateEpididymal spermMouse cauda epididymal spermFertilization abilityPharmacological effectsPotassium currentP-ERK1/2Phospho-ERK1/2Calcium concentrationChinese medicineKinase 1/2Male reproductionSignificant reductionMatrineMature mouse spermProgressive motilityAcrosome reactionMotilityTotal motility