2021
Pooled CRISPR screening identifies m6A as a positive regulator of macrophage activation
Tong J, Wang X, Liu Y, Ren X, Wang A, Chen Z, Yao J, Mao K, Liu T, Meng FL, Pan W, Zou Q, Liu J, Zhou Y, Xia Q, Flavell RA, Zhu S, Li HB. Pooled CRISPR screening identifies m6A as a positive regulator of macrophage activation. Science Advances 2021, 7: eabd4742. PMID: 33910903, PMCID: PMC8081357, DOI: 10.1126/sciadv.abd4742.Peer-Reviewed Original ResearchConceptsMacrophage activationPotential cancer immunotherapy targetInnate immune cellsFaster tumor growthTNF-α productionInnate immune responseCancer immunotherapy targetCre miceImmune cellsImmunotherapy targetImmune responseLPS stimulationTumor growthBacterial infectionsTop candidate genesDeficient macrophagesMultiple cellular responsesMETTL3 deficiencyActivationUnknown roleMETTL3Negative regulatorBinding proteinCellular responsesRNA binding protein
2014
Inflammasome activation and metabolic disease progression
Li HB, Jin C, Chen Y, Flavell RA. Inflammasome activation and metabolic disease progression. Cytokine & Growth Factor Reviews 2014, 25: 699-706. PMID: 25156419, DOI: 10.1016/j.cytogfr.2014.07.020.Peer-Reviewed Original ResearchConceptsObesity-associated metabolic diseasesCytokines IL-1βMetabolic stressInnate immune systemMetabolic disease progressionIL-18IL-1βWorldwide epidemicDisease progressionInflammasome activationMetabolic diseasesImmune systemCytosolic sensorsRecent evidenceInflammasomeNLRActivationDifferent tissuesMetabolic systems