Featured Publications
Transcriptomic organization of the human brain in post-traumatic stress disorder
Girgenti MJ, Wang J, Ji D, Cruz DA, Stein M, Gelernter J, Young K, Huber B, Williamson D, Friedman M, Krystal J, Zhao H, Duman R. Transcriptomic organization of the human brain in post-traumatic stress disorder. Nature Neuroscience 2020, 24: 24-33. PMID: 33349712, DOI: 10.1038/s41593-020-00748-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAutopsyBrain ChemistryCohort StudiesDepressive Disorder, MajorFemaleGene Expression RegulationGene Regulatory NetworksGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansInterneuronsMaleMiddle AgedNerve Tissue ProteinsSex CharacteristicsStress Disorders, Post-TraumaticTranscriptomeYoung AdultConceptsGenome-wide association studiesSignificant gene networksDifferential gene expressionSystems-level evidenceSignificant genetic liabilityMajor depressive disorder cohortGene networksTranscriptomic organizationTranscriptomic landscapeDownregulated setsGenomic networksGene expressionAssociation studiesMolecular determinantsExtensive remodelingGenotype dataSexual dimorphismSignificant divergenceMolecular profileNetwork analysisELFN1TranscriptsDimorphismPostmortem tissueDivergence
2013
Guilt by rewiring: gene prioritization through network rewiring in Genome Wide Association Studies
Hou L, Chen M, Zhang CK, Cho J, Zhao H. Guilt by rewiring: gene prioritization through network rewiring in Genome Wide Association Studies. Human Molecular Genetics 2013, 23: 2780-2790. PMID: 24381306, PMCID: PMC3990172, DOI: 10.1093/hmg/ddt668.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesWide association studyDisease-associated genesGWAS signalsNetwork rewiringAssociation studiesFunctional genomic informationGene expression networksCo-expression networkDisease-associated pathwaysExpression networksGene networksGenomic informationAssociation signalsGene prioritizationDisease genesDisease locusSusceptibility lociGenesAssociation principleRewiringDisease associationsLociMillions of candidatesDisease conditions