2019
Initial Results From An Opioid Dependence Whole Exome Sequencing Study
Gelernter J, Sherva R, Zhao H, Kranzler H, Farrer L. Initial Results From An Opioid Dependence Whole Exome Sequencing Study. European Neuropsychopharmacology 2019, 29: s732. DOI: 10.1016/j.euroneuro.2017.06.056.Peer-Reviewed Original ResearchOpioid dependenceWhole-exome sequencesAfrican AmericansCase/control studySubstance use disordersSensory neuron developmentRisk markersPain perceptionSynaptic responsesWhole-exome sequencing studiesOD diagnosisUse disordersControl studySynaptic plasticityNeuron developmentExome sequencing studiesSynapse functionEuropean AmericansPrdm12Myotonic dystrophyGene-based testsBonferroni correctionCommon risk variantsOD riskRisk variants
2015
Gene-based and pathway-based genome-wide association study of alcohol dependence
Lingjun Z, ZHANG CK, SAYWARD FG, CHEUNG KH, Kesheng W, KRYSTAL JH, Hongyu Z, Xingguang L. Gene-based and pathway-based genome-wide association study of alcohol dependence. General Psychiatry 2015, 27: 111-118. PMID: 26120261, PMCID: PMC4466852, DOI: 10.11919/j.issn.1002-0829.215031.Peer-Reviewed Original ResearchGenome-wide association studiesRisk genesAssociation studiesBiological signaling processesPXN geneGene pathwaysSignaling processesGlycan degradationInteraction pathwayGenetic markersTransporter pathwaysGenesDiscovery samplePathwayReplication sampleAfrican American casesRisk pathwaysMultiple testingBonferroni correctionNew evidence