2022
Neuroimaging Studies of Brain Structure in Older Adults with Bipolar Disorder: A Review
Rajashekar N, Blumberg HP, Villa LM. Neuroimaging Studies of Brain Structure in Older Adults with Bipolar Disorder: A Review. Journal Of Psychiatry And Brain Science 2022, 7: e220006. PMID: 36092855, PMCID: PMC9453888, DOI: 10.20900/jpbs.20220006.Peer-Reviewed Original ResearchBipolar disorderWhite matterBrain regionsBrain differencesDiffusion-weighted magnetic resonance imaging studiesOlder adultsMagnetic resonance imaging studyMood-stabilizing medicationsWhite matter findingsGray matter reductionsLater lifeCommon mood disorderYounger age groupsResonance imaging studyStructural brain differencesSubcortical brain regionsAdverse outcomesCognitive dysfunctionBrain changesClinical dataMood disordersProtective effectElevated riskHigh riskCognitive symptoms
2006
Age, Rapid-Cycling, and Pharmacotherapy Effects on Ventral Prefrontal Cortex in Bipolar Disorder: A Cross-Sectional Study
Blumberg HP, Krystal JH, Bansal R, Martin A, Dziura J, Durkin K, Martin L, Gerard E, Charney DS, Peterson BS. Age, Rapid-Cycling, and Pharmacotherapy Effects on Ventral Prefrontal Cortex in Bipolar Disorder: A Cross-Sectional Study. Biological Psychiatry 2006, 59: 611-618. PMID: 16414030, DOI: 10.1016/j.biopsych.2005.08.031.Peer-Reviewed Original ResearchConceptsHealthy comparison subjectsWhite matter volumeMagnetic resonance imagingMatter volumeBD patientsHigh-resolution structural magnetic resonance imagingYoung adulthoodStructural magnetic resonance imagingTotal brain volumeCross-sectional studyGray matter volumeAge group interactionVentral prefrontal cortexPharmacotherapy effectsPrefrontal cortex functionIllness featuresBD IProtective effectVolume abnormalitiesHC subjectsComparison subjectsBrain volumeVolume deficitsBipolar disorderRapid initial decline