2024
Aldehydes alter TGF-β signaling and induce obesity and cancer
Yang X, Bhowmick K, Rao S, Xiang X, Ohshiro K, Amdur R, Hassan M, Mohammad T, Crandall K, Cifani P, Shetty K, Lyons S, Merrill J, Vegesna A, John S, Latham P, Crawford J, Mishra B, Dasarathy S, Wang X, Yu H, Wang Z, Huang H, Krainer A, Mishra L. Aldehydes alter TGF-β signaling and induce obesity and cancer. Cell Reports 2024, 43: 114676. PMID: 39217614, PMCID: PMC11560041, DOI: 10.1016/j.celrep.2024.114676.Peer-Reviewed Original ResearchAldehyde dehydrogenase 2Small interfering RNADisease progression to cancerPro-oncogenic phenotypeTGF-bProgression to cancerGrowth factor BTGF-b signalingHuman metabolic syndromeSteatotic liver diseasePotential therapeutic targetMetabolic syndromePro-fibroticInduce obesityTherapeutic inhibitionLiver diseaseCurrent treatmentSmad3 signalingGlucose handlingTherapeutic targetFunctional phenotypeDehydrogenase 2Improve glucose handlingSPTBN1Obesity
2005
Tipping the Scales: The Effect of Literacy on Obese Patients’ Knowledge and Readiness to Lose Weight
Kennen E, Davis T, Huang J, Yu H, Carden D, Bass R, Arnold C. Tipping the Scales: The Effect of Literacy on Obese Patients’ Knowledge and Readiness to Lose Weight. Southern Medical Journal 2005, 98: 15-18. PMID: 15678634, DOI: 10.1097/01.smj.0000146617.21240.49.Peer-Reviewed Original ResearchConceptsObese patientsOverweight/obese patientsWeight lossHalf of patientsThird of patientsPrimary care clinicsAdverse health consequencesMean respondent ageLiteracy levelsCare clinicsPatient interviewsAdult outpatientsPatient educationPatientsHealth consequencesPublic hospitalsConvenience sampleLow literacyLow literacy skillsSignificant relationRespondent ageOverweightObesityOutpatientsLevels