2019
Lower antimüllerian hormone is associated with lower oocyte yield but not live-birth rate among women with obesity
Vitek W, Sun F, Baker VL, Styer AK, Christianson MS, Stern JE, Zhang H, Polotsky AJ. Lower antimüllerian hormone is associated with lower oocyte yield but not live-birth rate among women with obesity. American Journal Of Obstetrics And Gynecology 2019, 222: 363.e1-363.e7. PMID: 31589862, PMCID: PMC8022853, DOI: 10.1016/j.ajog.2019.09.046.Peer-Reviewed Original ResearchConceptsNormal body mass indexAntimüllerian hormone levelsLower antimüllerian hormoneBody mass indexLower oocyte yieldLive birth rateAntimüllerian hormoneLow ovarian reserveOocyte yieldMass indexHormone levelsOvarian reserveBody mass index 18.5Low antimüllerian hormone levelsAssisted Reproductive Technology Clinic Outcome Reporting System databaseLower live birth ratesClass 3 obesitySerum antimüllerian hormoneClass 1 obesityClass 2 obesityNumber of oocytesSmall antral folliclesReporting System databaseNormal BMIRetrospective cohortHuman chromatin remodeler cofactor, RNA interactor, eraser and writer sperm RNAs responding to obesity
Swanson GM, Estill M, Diamond MP, Legro RS, Coutifaris C, Barnhart KT, Huang H, Hansen KR, Trussell JC, Coward RM, Zhang H, Goodrich R, Krawetz SA. Human chromatin remodeler cofactor, RNA interactor, eraser and writer sperm RNAs responding to obesity. Epigenetics 2019, 15: 32-46. PMID: 31354029, PMCID: PMC6961666, DOI: 10.1080/15592294.2019.1644880.Peer-Reviewed Original ResearchConceptsSperm RNASperm DNA methylationChromosome organizationCoregulatory networkGene OntologyDNA methylationResponse pathwaysCellular stressRNA elementsRNAInteractorsErasersCofactorOvarian stimulation (AMIGOS) trialMethylationObesity-related inflammationTranscriptsMeasures of obesityAdipogenesisPathwayMultiple gestationsStimulation trialsAnimal modelsBMIHuman studies
2018
Gestational Weight Gain in Women With Polycystic Ovary Syndrome: A Controlled Study
Kent J, Dodson WC, Kunselman A, Pauli J, Stone A, Diamond MP, Coutifaris C, Schlaff WD, Alvero R, Casson P, Christman GM, Rosen RM, Hansen KR, Robinson R, Baker V, Usadi R, Santoro N, Zhang H, Eisenberg E, Legro RS, Network R. Gestational Weight Gain in Women With Polycystic Ovary Syndrome: A Controlled Study. The Journal Of Clinical Endocrinology & Metabolism 2018, 103: 4315-4323. PMID: 30085187, PMCID: PMC6194806, DOI: 10.1210/jc.2017-02764.Peer-Reviewed Original ResearchConceptsPreconception body mass indexGestational weight gainPolycystic ovary syndromeBody mass indexOvulatory controlsPregnancy complicationsOvary syndromeObese groupWeight gainSecond trimesterExcessive gestational weight gainPre-existing obesityProspective cohort studyNormal-weight womenContribution of diagnosisPreconception baselinePreconception weightGestational diabetesPerinatal outcomesCohort studyPerinatal complicationsSingleton pregnanciesMass indexNormal weightFirst trimester
2016
Benefit of Delayed Fertility Therapy With Preconception Weight Loss Over Immediate Therapy in Obese Women With PCOS
Legro RS, Dodson WC, Kunselman AR, Stetter CM, Kris-Etherton PM, Williams NI, Gnatuk CL, Estes SJ, Allison KC, Sarwer DB, Diamond MP, Schlaff WD, Casson PR, Christman GM, Barnhart KT, Bates GW, Usadi R, Lucidi S, Baker V, Zhang H, Eisenberg E, Coutifaris C, Dokras A. Benefit of Delayed Fertility Therapy With Preconception Weight Loss Over Immediate Therapy in Obese Women With PCOS. The Journal Of Clinical Endocrinology & Metabolism 2016, 101: 2658-2666. PMID: 27172435, PMCID: PMC4929837, DOI: 10.1210/jc.2016-1659.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnti-Obesity AgentsBehavior TherapyClomipheneCombined Modality TherapyContraceptives, Oral, HormonalFemaleFertility Agents, FemaleHumansInfertility, FemaleLife StyleObesityPolycystic Ovary SyndromePreconception CarePregnancyPregnancy RateReproductive Techniques, AssistedTime FactorsWeight LossYoung AdultConceptsPolycystic ovary syndromeImmediate treatmentLifestyle modificationObese womenOral contraceptivesInfertility treatmentPolycystic Ovary Syndrome trialCumulative live birth rateOvulation rateWeight lossContinuous oral contraceptivesCumulative ovulation rateCycles of clomipheneOral contraceptive pretreatmentPreconception weight lossLive birth rateOverweight/obeseConcurrent clinical trialsYears of ageBirth rateImproved ovulationPPCOS IIPreconception treatmentClomiphene citrateII trial
2013
The Pregnancy in Polycystic Ovary Syndrome II study: baseline characteristics and effects of obesity from a multicenter randomized clinical trial
Legro RS, Brzyski RG, Diamond MP, Coutifaris C, Schlaff WD, Alvero R, Casson P, Christman GM, Huang H, Yan Q, Haisenleder DJ, Barnhart KT, Bates GW, Usadi R, Lucidi R, Baker V, Trussell JC, Krawetz SA, Snyder P, Ohl D, Santoro N, Eisenberg E, Zhang H, Network I. The Pregnancy in Polycystic Ovary Syndrome II study: baseline characteristics and effects of obesity from a multicenter randomized clinical trial. Fertility And Sterility 2013, 101: 258-269.e8. PMID: 24156957, PMCID: PMC3899700, DOI: 10.1016/j.fertnstert.2013.08.056.Peer-Reviewed Original ResearchConceptsAntimüllerian hormone levelsAntral follicle countPolycystic ovary syndromeBaseline characteristicsFollicle countClinical trialsHormone levelsCross-sectional baseline dataCardiovascular risk factorsEffect of obesityMost metabolic parametersMean semen parametersFSH ratioFSH levelsII studyOvarian volumeOvary syndromeMetabolic syndromeTreatment regimensRisk factorsHealth centersMetabolic dysfunctionMetabolic parametersMAIN OUTCOMETreatment groups