2015
Cluster analysis of spontaneous preterm birth phenotypes identifies potential associations among preterm birth mechanisms
Esplin MS, Manuck TA, Varner MW, Christensen B, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J. Cluster analysis of spontaneous preterm birth phenotypes identifies potential associations among preterm birth mechanisms. American Journal Of Obstetrics And Gynecology 2015, 213: 429.e1-429.e9. PMID: 26070700, PMCID: PMC4556543, DOI: 10.1016/j.ajog.2015.06.011.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthDecidual hemorrhagePlacental dysfunctionProspective case-control multicenter studyCase-control multicenter studyPremature membrane ruptureGroup of womenCommon biologic pathwaysMaternal comorbiditiesPreterm singletonsPreterm birthWeeks' gestationMulticenter studyMaternal stressSecondary analysisBiologic pathwaysFamilial factorsGenetic factorsWomenPhenotypic profileGestationInfectionMembrane ruptureCommon mechanismPhenotype
2014
Modified screening and ranking algorithm for copy number variation detection
Xiao F, Min X, Zhang H. Modified screening and ranking algorithm for copy number variation detection. Bioinformatics 2014, 31: 1341-1348. PMID: 25542927, PMCID: PMC4410664, DOI: 10.1093/bioinformatics/btu850.Peer-Reviewed Original Research
2011
Sex differences in grey matter atrophy patterns among AD and aMCI patients: Results from ADNI
Skup M, Zhu H, Wang Y, Giovanello KS, Lin JA, Shen D, Shi F, Gao W, Lin W, Fan Y, Zhang H, Initiative T. Sex differences in grey matter atrophy patterns among AD and aMCI patients: Results from ADNI. NeuroImage 2011, 56: 890-906. PMID: 21356315, PMCID: PMC3085726, DOI: 10.1016/j.neuroimage.2011.02.060.Peer-Reviewed Original ResearchConceptsGrey matter atrophy patternsAlzheimer's Disease Neuroimaging InitiativeProbable Alzheimer's diseaseAlzheimer's diseaseAmnestic mild cognitive impairmentAtrophy patternsDisease Neuroimaging InitiativeLongitudinal magnetic resonance imaging (MRI) dataPredetermined brain regionsBilateral caudate nucleusAMCI groupBilateral middle temporal gyrusVoxel-wise analysisMild cognitive impairmentGray matter regionsMiddle temporal gyrusBilateral thalamusBrain atrophyStructural MRI dataHealthy controlsGrey matter dataMagnetic resonance imaging dataAD groupBilateral precuneusCaudate nucleus
2008
Diffusible retinal secretions regulate the expression of tight junctions and other diverse functions of the retinal pigment epithelium.
Sun R, Peng S, Chen X, Zhang H, Rizzolo LJ. Diffusible retinal secretions regulate the expression of tight junctions and other diverse functions of the retinal pigment epithelium. Molecular Vision 2008, 14: 2237-62. PMID: 19057659, PMCID: PMC2593753.Peer-Reviewed Original ResearchMeSH KeywordsActinsAdherens JunctionsAnimalsCell MembraneCells, CulturedChick EmbryoCluster AnalysisCulture Media, ConditionedDiffusionElectric ImpedanceExtracellular MatrixGene Expression ProfilingGene Expression Regulation, DevelopmentalGenomeIon ChannelsKineticsMelaninsMembrane ProteinsMicrotubulesOligonucleotide Array Sequence AnalysisPhagocytosisRetinal Pigment EpitheliumRNA, MessengerSubcellular FractionsTight JunctionsVisual PathwaysConceptsGene expression
2007
Analysis of the RPE transcriptome reveals dynamic changes during the development of the outer blood-retinal barrier.
Rizzolo LJ, Chen X, Weitzman M, Sun R, Zhang H. Analysis of the RPE transcriptome reveals dynamic changes during the development of the outer blood-retinal barrier. Molecular Vision 2007, 13: 1259-73. PMID: 17679949.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsBlood-Retinal BarrierCell Cycle ProteinsChick EmbryoCluster AnalysisCollagenExtracellular MatrixGene Expression ProfilingIntercellular JunctionsLamininMembrane ProteinsMicrotubule-Associated ProteinsMyosinsOligonucleotide Array Sequence AnalysisPhagocytosisPigment Epithelium of EyeProtein SubunitsProteinsReceptors, Cell SurfaceReverse Transcriptase Polymerase Chain ReactionRNA, MessengerTranscription, GeneticConceptsPattern of expressionExtensive remodelingAffymetrix microarray chipsCell-cell junctionsSignal transduction pathwaysExtracellular matrix interactionsAdherens junction proteinsTranscellular ion transportCell surface receptorsGenomic approachesEntire genomeGene OntologyTransduction pathwaysSTEM softwareZO-3Biological pathwaysFunctional clusteringMatrix interactionsExtracellular matrixSurface receptorsJunctional complexesMicroarray chipContinuous remodelingFalse discovery rateAffymetrix software
2004
Correcting the loss of cell-cycle synchrony in clustering analysis of microarray data using weights
Duan F, Zhang H. Correcting the loss of cell-cycle synchrony in clustering analysis of microarray data using weights. Bioinformatics 2004, 20: 1766-1771. PMID: 15166015, DOI: 10.1093/bioinformatics/bth169.Peer-Reviewed Original ResearchAlgorithmsBiological ClocksCell CycleCluster AnalysisGene Expression ProfilingGene Expression Regulation, FungalModels, GeneticModels, StatisticalOligonucleotide Array Sequence AnalysisPattern Recognition, AutomatedReproducibility of ResultsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSensitivity and SpecificityTime Factors