2018
Modeling hybrid traits for comorbidity and genetic studies of alcohol and nicotine co-dependence
Zhang H, Liu D, Zhao J, Bi X. Modeling hybrid traits for comorbidity and genetic studies of alcohol and nicotine co-dependence. The Annals Of Applied Statistics 2018, 12: 2359-2378. PMID: 30666272, PMCID: PMC6338437, DOI: 10.1214/18-aoas1156.Peer-Reviewed Original ResearchFull likelihoodComplicated likelihood functionsParametric frameworkParametric modeling frameworkHigh computational complexityExtensive simulation studyModel fitting algorithmStatistical inferenceRank-based methodLikelihood functionComputational burdenType I error ratesComputational complexityFitting algorithmSimulation studyNovel multivariate modelModeling frameworkEffect size estimationLatent variablesHybrid modelInferenceSize estimationModelFrameworkTheory
2016
Energy bagging tree.
Cao T, Wang X, Zhang H. Energy bagging tree. Statistics And Its Interface 2016, 9: 171-181. PMID: 26594301, PMCID: PMC4648255, DOI: 10.4310/sii.2016.v9.n2.a5.Peer-Reviewed Original ResearchMeasures of dispersionMultivariate nonparametric regression problemReal data analysisNonparametric regression problemsGini’s mean differenceNon-parametric extensionExtensive simulation studyRegression problemsSimulation studyEnergy distanceComplex dataBagging treesRegression tree methodTree methodSample variationData analysisDispersion
2015
Association Tests of Multiple Phenotypes: ATeMP
Guo X, Li Y, Ding X, He M, Wang X, Zhang H. Association Tests of Multiple Phenotypes: ATeMP. PLOS ONE 2015, 10: e0140348. PMID: 26479245, PMCID: PMC4610695, DOI: 10.1371/journal.pone.0140348.Peer-Reviewed Original ResearchConceptsExtensive simulation studyStatistical literatureJoint association analysisMultiPhenSimulation studyEquivalence relationshipProportional odds modelReal case studyMeasurement errorMultivariate methodsOdds modelMultiple intermediate phenotypesJoint analysisMultiple phenotypesExplanatory variablesEquivalenceEstimationDistributionPhenotypic distributionATempSolutionError
2007
Statistical Analysis of Diffusion Tensors in Diffusion-Weighted Magnetic Resonance Imaging Data
Zhu H, Zhang H, Ibrahim J, Peterson B. Statistical Analysis of Diffusion Tensors in Diffusion-Weighted Magnetic Resonance Imaging Data. Journal Of The American Statistical Association 2007, 102: 1085-1102. DOI: 10.1198/016214507000000581.Peer-Reviewed Original ResearchA score test for linkage analysis of ordinal traits based on IBD sharing
Feng R, Zhang H. A score test for linkage analysis of ordinal traits based on IBD sharing. Biostatistics 2007, 9: 114-127. PMID: 17519391, DOI: 10.1093/biostatistics/kxm016.Peer-Reviewed Original Research
2006
Generalized score test of homogeneity for mixed effects models
Zhu H, Zhang H. Generalized score test of homogeneity for mixed effects models. The Annals Of Statistics 2006, 34: 1545-1569. DOI: 10.1214/009053606000000380.Peer-Reviewed Original ResearchTest statisticsAsymptotic distributionRandom quadratic formsGeneralized score testQuadratic formInvariance principleScore testTest of homogeneityLatent variable modelsSimulation studyResampling procedureRestrictive assumptionsEmpirical performanceHomogeneity hypothesisTheoretical resultsVariance componentsVariable modelTest procedureBiomedical studiesMild conditionsInvarianceOverdispersionImportant problemsAssumptionsObservational data
2003
Hypothesis testing in mixture regression models
Zhu H, Zhang H. Hypothesis testing in mixture regression models. Journal Of The Royal Statistical Society Series B (Statistical Methodology) 2003, 66: 3-16. DOI: 10.1046/j.1369-7412.2003.05379.x.Peer-Reviewed Original ResearchMixture regression modelLikelihood estimatorTest statisticLog-likelihood ratio test statisticOptimal convergence ratesMaximum likelihoodRatio test statisticAsymptotic theoryReal data setsAsymptotic distributionConvergence rateTheoretical resultsEmpirical performanceReasonable conditionsSimulation studyHypothesis testingEstimatorStatisticsData setsRegression modelsModelTheoryDistributionA Latent Variable Model of Segregation Analysis for Ordinal Traits
Zhang H, Feng R, Zhu H. A Latent Variable Model of Segregation Analysis for Ordinal Traits. Journal Of The American Statistical Association 2003, 98: 1023-1034. DOI: 10.1198/016214503000000981.Peer-Reviewed Original ResearchDichotomous traitsLatent variable modelsAsymptotic theoryModel of segregation analysisFamilial transmission of alcoholismGene-environment interactionsAssessed familial aggregationConduct simulation studiesGenetic epidemiologySegregation analysisTransmission of alcoholismHealth conditionsOrdinal traitsFamilial aggregationBinary traitsVariable modelComplex genetic basisInheritance of diseaseStatistical inferenceEM algorithmEnvironmental factorsSimulation studyPsychiatric disordersGene componentsAlcohol abuseIdentification of Linear Directions in Multivariate Adaptive Spline Models
Zhang H, Yu C, Zhu H, Shi J. Identification of Linear Directions in Multivariate Adaptive Spline Models. Journal Of The American Statistical Association 2003, 98: 369-376. DOI: 10.1198/016214503000152.Peer-Reviewed Original Research