Endometrial Shedding Effect on Conception and Live Birth in Women With Polycystic Ovary Syndrome
Diamond M, Kruger M, Santoro N, Zhang H, Casson P, Schlaff W, Coutifaris C, Brzyski R, Christman G, Carr B, McGovern P, Cataldo N, Steinkampf M, Gosman G, Nestler J, Carson S, Myers E, Eisenberg E, Legro R. Endometrial Shedding Effect on Conception and Live Birth in Women With Polycystic Ovary Syndrome. Obstetrical & Gynecological Survey 2012, 67: 548-549. DOI: 10.1097/01.ogx.0000421452.19985.8f.Peer-Reviewed Original ResearchPolycystic ovary syndromeLive birth rateProgestin withdrawalEndometrial sheddingLive birthsAnovulatory womenClomiphene citrateOvary syndromeOvulation inductionSpontaneous mensesProgestin-induced withdrawal bleedingEunice Kennedy Shriver National InstituteBirth rateAdministration of clomipheneOligo-ovulatory womenPrevious bleeding episodesDouble-blind trialFirst-line therapyCommon clinical practiceUse of progestinsOccurrence of ovulationRate of conceptionWithdrawal bleedWithdrawal bleedingBleeding episodesEndometrial Shedding Effect on Conception and Live Birth in Women With Polycystic Ovary Syndrome
Diamond MP, Kruger M, Santoro N, Zhang H, Casson P, Schlaff W, Coutifaris C, Brzyski R, Christman G, Carr BR, McGovern PG, Cataldo NA, Steinkampf MP, Gosman GG, Nestler JE, Carson S, Myers EE, Eisenberg E, Legro RS. Endometrial Shedding Effect on Conception and Live Birth in Women With Polycystic Ovary Syndrome. Obstetrics And Gynecology 2012, 119: 902-908. PMID: 22525900, PMCID: PMC4007263, DOI: 10.1097/aog.0b013e31824da35c.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeLive birth rateAnovulatory cyclesEndometrial sheddingClomiphene citrateOvary syndromeLive birthsEunice Kennedy Shriver National InstituteBirth rateCommon clinical practiceOccurrence of ovulationRate of conceptionAnovulatory womenOvarian stimulationOvulation inductionSpontaneous mensesProgestin withdrawalChild healthClinical practiceNetwork trialSecondary analysisOvulation rateMetforminAdverse effectsWomenThe Pregnancy in Polycystic Ovary Syndrome II (PPCOS II) trial: Rationale and design of a double-blind randomized trial of clomiphene citrate and letrozole for the treatment of infertility in women with polycystic ovary syndrome
Legro RS, Kunselman AR, Brzyski RG, Casson PR, Diamond MP, Schlaff WD, Christman GM, Coutifaris C, Taylor HS, Eisenberg E, Santoro N, Zhang H, Network F. The Pregnancy in Polycystic Ovary Syndrome II (PPCOS II) trial: Rationale and design of a double-blind randomized trial of clomiphene citrate and letrozole for the treatment of infertility in women with polycystic ovary syndrome. Contemporary Clinical Trials 2012, 33: 470-481. PMID: 22265923, PMCID: PMC3312939, DOI: 10.1016/j.cct.2011.12.005.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntineoplastic AgentsChi-Square DistributionClomipheneDouble-Blind MethodFemaleFertility Agents, FemaleHealth Status IndicatorsHirsutismHumansHyperandrogenismInfertility, FemaleLetrozoleMiddle AgedNitrilesOvulation InductionPolycystic Ovary SyndromePregnancyQuality of LifeResearch DesignTriazolesWomen's HealthYoung AdultConceptsPolycystic ovary syndromeClomiphene citrateOvary syndromeInfertile womenTreatment armsDouble-blind clinical trialSelective estrogen receptor modulatorsMajor infertility factorOral clomiphene citrateMultiple pregnancy rateFirst-line treatmentLive birth rateEstrogen receptor modulatorsDifferent treatment armsTreatment of infertilityPoor ovulatory responseEndometrial effectsII trialII studyLine treatmentInfertility factorsProgestin withdrawalAromatase inhibitorsClinical trialsFemale infertility