2021
Pan‐cancer analysis of prognostic metastatic phenotypes
Zaorsky NG, Wang X, Garrett SM, Lehrer EJ, Lin C, DeGraff DJ, Spratt DE, Trifiletti DM, Kishan AU, Showalter TN, Park HS, Yang JT, Chinchilli VM, Wang M. Pan‐cancer analysis of prognostic metastatic phenotypes. International Journal Of Cancer 2021, 150: 132-141. PMID: 34287840, PMCID: PMC8595638, DOI: 10.1002/ijc.33744.Peer-Reviewed Original ResearchConceptsLiver/lung metastasisLung metastasesOverall survivalMetastatic cancerConcordance indexCancer stage IV diseaseCox proportional hazards modelMetastatic phenotypeNational Cancer DatabaseStage IV diseaseEnd Results (SEER) databaseAmerican Joint CommitteeLong-term survivorsLatent class analysisProportional hazards modelStage IVANomogram modelResults databaseSurvival outcomesBetter prognosticationCancer DatabasePan-cancer analysisClinical trialsHazards modelJoint CommitteeFinancial relationships between industry and principal investigators of US cooperative group randomized cancer clinical trials
Metzger AL, Appiah A, Wright CM, Jairam V, Amini A, Park HS, Welsh JW, Thomas CR, Verma V, Ludmir EB. Financial relationships between industry and principal investigators of US cooperative group randomized cancer clinical trials. International Journal Of Cancer 2021, 149: 1683-1690. PMID: 34173669, DOI: 10.1002/ijc.33719.Peer-Reviewed Original ResearchConceptsClinical trialsMultivariable gamma regression analysesNational Clinical Trials NetworkPrincipal investigatorPhase III componentSystemic therapy trialsUS cooperative groupsClinical Trials NetworkCooperative groupsCancer clinical trialsGamma regression analysisSystemic therapySuch RCTsTherapy trialsRCTsTrials NetworkTrialsRegression analysisOne-thirdMedical journalsDrugsPrevalence of Missing Data in the National Cancer Database and Association With Overall Survival
Yang DX, Khera R, Miccio JA, Jairam V, Chang E, Yu JB, Park HS, Krumholz HM, Aneja S. Prevalence of Missing Data in the National Cancer Database and Association With Overall Survival. JAMA Network Open 2021, 4: e211793. PMID: 33755165, PMCID: PMC7988369, DOI: 10.1001/jamanetworkopen.2021.1793.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseNon-small cell lung cancerOverall survivalCell lung cancerCancer DatabaseMedical recordsLung cancerProstate cancerBreast cancerPatient recordsComplete dataRetrospective cohort studyCohort studyCancer RegistryCommon cancerVariables of interestHigh prevalenceMAIN OUTCOMEPatientsClinical advancementReal-world data sourcesCancerPrevalenceSurvivalHeterogeneous differences
2020
Nationwide patterns of hemorrhagic stroke among patients hospitalized with brain metastases: influence of primary cancer diagnosis and anticoagulation
Lee V, Jairam V, Yu JB, Park HS. Nationwide patterns of hemorrhagic stroke among patients hospitalized with brain metastases: influence of primary cancer diagnosis and anticoagulation. Scientific Reports 2020, 10: 10084. PMID: 32572113, PMCID: PMC7308286, DOI: 10.1038/s41598-020-67316-8.Peer-Reviewed Original ResearchConceptsBrain metastasesLong-term anticoagulationIntracerebral hemorrhageKidney cancerHigh riskUtilization Project Nationwide Inpatient SampleDiagnosis of ICHHospital-related characteristicsRisks of anticoagulationPrimary cancer diagnosisMultivariable logistic regressionNationwide Inpatient SampleLonger lengthDiagnosis of melanomaMann-Whitney UHemorrhagic strokeNeurologic dysfunctionConcurrent diagnosisSignificant morbiditySecondary diagnosisInpatient SampleBaseline differencesDecreased qualityAnticoagulationHealthcare costsProton-Based Chemoradiotherapy—What Level of Evidence Is Necessary to Justify Its Widespread Use?
Park HS, Yu JB. Proton-Based Chemoradiotherapy—What Level of Evidence Is Necessary to Justify Its Widespread Use? JAMA Oncology 2020, 6: 246-247. PMID: 31876903, DOI: 10.1001/jamaoncol.2019.4875.Peer-Reviewed Original Research
2019
Emergency Department Visits for Opioid Overdoses Among Patients With Cancer
Jairam V, Yang DX, Yu JB, Park HS. Emergency Department Visits for Opioid Overdoses Among Patients With Cancer. Journal Of The National Cancer Institute 2019, 112: 938-943. PMID: 31845985, PMCID: PMC7492769, DOI: 10.1093/jnci/djz233.Peer-Reviewed Original ResearchConceptsOpioid-related ED visitsED visitsEmergency departmentOpioid overdoseComorbid diagnosesUtilization Project Nationwide Emergency Department SampleMultivariable logistic regression analysisNationwide Emergency Department SampleHigh opioid useOpioid-related visitsPrimary disease siteEmergency department visitsEmergency Department SampleLogistic regression analysisSubstance use disordersOpioid useDepartment visitsChronic painMultiple myelomaNeck cancerPrimary diagnosisRisk factorsPatient visitsBaseline differencesOpioid overdosesError Types and Associations of Clinically Significant Events Within Food and Drug Administration Recalls of Linear Accelerators and Related Products
Jairam V, Lincoln H, Brown D, Park HS, Evans SB. Error Types and Associations of Clinically Significant Events Within Food and Drug Administration Recalls of Linear Accelerators and Related Products. Practical Radiation Oncology 2019, 10: e8-e15. PMID: 31408733, DOI: 10.1016/j.prro.2019.08.001.Peer-Reviewed Original ResearchTreatment-Related Complications of Systemic Therapy and Radiotherapy
Jairam V, Lee V, Park HS, Thomas CR, Melnick ER, Gross CP, Presley CJ, Adelson KB, Yu JB. Treatment-Related Complications of Systemic Therapy and Radiotherapy. JAMA Oncology 2019, 5: 1028-1035. PMID: 30946433, PMCID: PMC6583836, DOI: 10.1001/jamaoncol.2019.0086.Peer-Reviewed Original ResearchConceptsTreatment-related complicationsOverall ED visitsAcute kidney injuryED visitsSystemic therapyInpatient admissionsEmergency departmentKidney injuryCommon complicationMAIN OUTCOMEUtilization Project Nationwide Emergency Department SampleFinancial burdenNationwide Emergency Department SampleHospital-related factorsClinical Modification codesEmergency Department SampleClinical Classification SoftwareTotal financial burdenInternational Statistical ClassificationOverall financial burdenHigh rateRelated Health ProblemsAcute complicationsStudy cohortNinth RevisionSuicide among cancer patients
Zaorsky NG, Zhang Y, Tuanquin L, Bluethmann SM, Park HS, Chinchilli VM. Suicide among cancer patients. Nature Communications 2019, 10: 207. PMID: 30643135, PMCID: PMC6331593, DOI: 10.1038/s41467-018-08170-1.Peer-Reviewed Original ResearchConceptsStandardized mortality ratioCancer patientsHigh riskHigher standardized mortality ratiosColorectal cancer patientsEnd Results ProgramPopulation-based studyYears of agePredominant patientsLocalized diseasePerson yearsResults ProgramHodgkin's lymphomaTesticular tumorsMortality ratioRates of suicideGeneral populationPatientsCommitted suicideUnmarried malesLungSuicideRiskRepresentative dataLymphoma
2018
Complementary Medicine, Refusal of Conventional Cancer Therapy, and Survival Among Patients With Curable Cancers
Johnson SB, Park HS, Gross CP, Yu JB. Complementary Medicine, Refusal of Conventional Cancer Therapy, and Survival Among Patients With Curable Cancers. JAMA Oncology 2018, 4: 1375-1381. PMID: 30027204, PMCID: PMC6233773, DOI: 10.1001/jamaoncol.2018.2487.Peer-Reviewed Original ResearchConceptsConventional cancer treatmentsUse of CMOverall survivalComplementary medicineHormone therapyTreatment delayCharlson-Deyo comorbidity scoreCancer treatmentCancer-accredited centersNational Cancer DatabaseCharacteristics of patientsYear of diagnosisRetrospective observational studyConventional cancer therapiesHigh refusal rateRace/ethnicityNonmetastatic breastComorbidity scorePatient characteristicsCurable cancerEntire cohortColorectal cancerCancer DatabaseInsurance typeObservational study
2012
Using the Surveillance, Epidemiology, and End Results Database to Investigate Rare Cancers, Second Malignancies, and Trends in Epidemiology, Treatment, and Outcomes
Lloyd S, Park HS, Decker RH, Wilson LD, Yu JB. Using the Surveillance, Epidemiology, and End Results Database to Investigate Rare Cancers, Second Malignancies, and Trends in Epidemiology, Treatment, and Outcomes. Current Problems In Cancer 2012, 36: 191-199. PMID: 22495057, DOI: 10.1016/j.currproblcancer.2012.03.008.Peer-Reviewed Original ResearchComparative Effectiveness Research and the Surveillance, Epidemiology, and End Results Database
Yu JB, Lloyd S, Decker RH, Wilson LD, Park HS. Comparative Effectiveness Research and the Surveillance, Epidemiology, and End Results Database. Current Problems In Cancer 2012, 36: 208-215. PMID: 22481005, DOI: 10.1016/j.currproblcancer.2012.03.010.Peer-Reviewed Original ResearchPrediction Models, Nomograms, and Staging Validation with the Surveillance, Epidemiology, and End Results Database
Lloyd S, Park HS, Wilson LD, Decker RH, Yu JB. Prediction Models, Nomograms, and Staging Validation with the Surveillance, Epidemiology, and End Results Database. Current Problems In Cancer 2012, 36: 200-207. PMID: 22481008, DOI: 10.1016/j.currproblcancer.2012.03.009.Peer-Reviewed Original ResearchOverview of the Surveillance, Epidemiology, and End Results Database: Evolution, Data Variables, and Quality Assurance
Park HS, Lloyd S, Decker RH, Wilson LD, Yu JB. Overview of the Surveillance, Epidemiology, and End Results Database: Evolution, Data Variables, and Quality Assurance. Current Problems In Cancer 2012, 36: 183-190. PMID: 22481006, DOI: 10.1016/j.currproblcancer.2012.03.007.Peer-Reviewed Original ResearchLimitations and Biases of the Surveillance, Epidemiology, and End Results Database
Park HS, Lloyd S, Decker RH, Wilson LD, Yu JB. Limitations and Biases of the Surveillance, Epidemiology, and End Results Database. Current Problems In Cancer 2012, 36: 216-224. PMID: 22481009, DOI: 10.1016/j.currproblcancer.2012.03.011.Peer-Reviewed Original Research