2022
Changes in Prostate-Specific Antigen Testing Relative to the Revised US Preventive Services Task Force Recommendation on Prostate Cancer Screening
Leapman MS, Wang R, Park H, Yu JB, Sprenkle PC, Cooperberg MR, Gross CP, Ma X. Changes in Prostate-Specific Antigen Testing Relative to the Revised US Preventive Services Task Force Recommendation on Prostate Cancer Screening. JAMA Oncology 2022, 8: 41-47. PMID: 34762100, PMCID: PMC8587214, DOI: 10.1001/jamaoncol.2021.5143.Peer-Reviewed Original ResearchConceptsProstate cancer screeningUS Preventive Services Task ForcePSA testingCancer screeningInterrupted time series analysisCohort studyUS Preventive Services Task Force (USPSTF) recommendationDraft statementLarge national cohort studyEligible beneficiariesPSA testing ratesRetrospective cohort studyRate of PSANational cohort studyProstate-specific antigenAge-adjusted ratesTask Force recommendationsUSPSTF guidelinesMedian ageGuideline changesProstate cancerMedian numberMAIN OUTCOMEClaims dataTesting rates
2021
Facility-Level Variation in Use of Locoregional Therapy for Metastatic Prostate Cancer
Buck M, Ghiraldi E, Demkowicz P, Park H, An Y, Kann B, Yu J, Sprenkle P, Kim I, Leapman M. Facility-Level Variation in Use of Locoregional Therapy for Metastatic Prostate Cancer. Urology Practice 2021, 9: 141-149. PMID: 37145694, DOI: 10.1097/upj.0000000000000290.Peer-Reviewed Original ResearchMetastatic prostate cancerLocal therapyProstate cancerLocoregional therapyFacility-level useFacility-level variationM1 prostate cancerDefinitive local therapyNational Cancer DatabaseMetastatic prostate adenocarcinomaClinical practice guidelinesMultilevel logistic regressionM1 diseasePatient factorsTherapy useUninsured statusRadical prostatectomyCancer DatabaseProstate adenocarcinomaHigh comorbidityLocal treatmentPatient levelPractice guidelinesLower oddsPatientsEmergency department visits for radiation cystitis among patients with a prostate cancer history
Lee V, An Y, Park HS, Yu JB, Kim SP, Jairam V. Emergency department visits for radiation cystitis among patients with a prostate cancer history. BJU International 2021, 130: 208-216. PMID: 34806813, DOI: 10.1111/bju.15650.Peer-Reviewed Original ResearchConceptsProstate cancer historyRadiation cystitisED visitsInvasive proceduresCancer historyProstate cancerRadiation therapyHigher median total chargesNationwide Emergency Department SampleEmergency department visitsEmergency Department SampleMedian total chargesPrior prostatectomyUrinary retentionBlood transfusionDepartment visitsMedian lengthEmergency departmentNational burdenSecondary diagnosisPrimary diagnosisHospital characteristicsPotential complicationsEffective modalityInvasive measuresAdoption of New Risk Stratification Technologies Within US Hospital Referral Regions and Association With Prostate Cancer Management
Leapman MS, Wang R, Park HS, Yu JB, Sprenkle PC, Dinan MA, Ma X, Gross CP. Adoption of New Risk Stratification Technologies Within US Hospital Referral Regions and Association With Prostate Cancer Management. JAMA Network Open 2021, 4: e2128646. PMID: 34623406, PMCID: PMC8501394, DOI: 10.1001/jamanetworkopen.2021.28646.Peer-Reviewed Original ResearchConceptsProstate magnetic resonance imagingMagnetic resonance imagingHospital referral regionsProportion of patientsProstate cancerGenomic testingCohort studyReferral regionsRetrospective cohort studyProstate cancer carePatient-level analysisCommercial insurance claimsProstate cancer managementUS hospital referral regionsYears of ageProportion of menPatients 40Definitive treatmentCancer careTesting uptakeHRR levelMAIN OUTCOMECancer managementPatientsRegional uptakePrevalence of Missing Data in the National Cancer Database and Association With Overall Survival
Yang DX, Khera R, Miccio JA, Jairam V, Chang E, Yu JB, Park HS, Krumholz HM, Aneja S. Prevalence of Missing Data in the National Cancer Database and Association With Overall Survival. JAMA Network Open 2021, 4: e211793. PMID: 33755165, PMCID: PMC7988369, DOI: 10.1001/jamanetworkopen.2021.1793.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseNon-small cell lung cancerOverall survivalCell lung cancerCancer DatabaseMedical recordsLung cancerProstate cancerBreast cancerPatient recordsComplete dataRetrospective cohort studyCohort studyCancer RegistryCommon cancerVariables of interestHigh prevalenceMAIN OUTCOMEPatientsClinical advancementReal-world data sourcesCancerPrevalenceSurvivalHeterogeneous differences
2020
Quantifying treatment selection bias effect on survival in comparative effectiveness research: findings from low-risk prostate cancer patients
Miccio JA, Talcott WJ, Jairam V, Park HS, Yu JB, Leapman MS, Johnson SB, King MT, Nguyen PL, Kann BH. Quantifying treatment selection bias effect on survival in comparative effectiveness research: findings from low-risk prostate cancer patients. Prostate Cancer And Prostatic Diseases 2020, 24: 414-422. PMID: 32989262, DOI: 10.1038/s41391-020-00291-3.Peer-Reviewed Original ResearchConceptsProstate cancer-specific survivalLow-risk prostate cancerExternal beam radiotherapyTreatment selection biasOverall survivalRadical prostatectomyProstate cancerOS differenceLow-risk prostate cancer patientsCancer-specific survivalEnd Results (SEER) databaseProstate cancer patientsClinical trial designEffectiveness researchComparative effectiveness researchPropensity-score matchingMethodsThe SurveillanceTreatment guidelinesResults databaseEntire cohortResultsA totalCancer patientsTreatment modalitiesNational registryPatient managementRadiation Dose to the Rectum With Definitive Radiation Therapy and Hydrogel Spacer Versus Postprostatectomy Radiation Therapy
Yang DX, Verma V, An Y, Yu JB, Sprenkle PC, Leapman MS, Park HS. Radiation Dose to the Rectum With Definitive Radiation Therapy and Hydrogel Spacer Versus Postprostatectomy Radiation Therapy. Advances In Radiation Oncology 2020, 5: 1225-1231. PMID: 33305083, PMCID: PMC7718530, DOI: 10.1016/j.adro.2020.08.015.Peer-Reviewed Original ResearchDefinitive radiation therapyPostoperative radiation therapyHydrogel spacerRadiation therapyRectal dosimetryProstate cancerGroup 1Rectal dose-volume parametersPostprostatectomy radiation therapyDose-volume parametersPostprostatectomy settingSurgical patientsPrimary managementRectal volumeDefinitive settingRadical prostatectomyRectal dosesGroup 2High riskPatientsLinear regression analysisProstatectomyMann-WhitneyTherapyCancer
2019
P28 Rectal Radiation Dose Comparison Between Definitive Radiotherapy with Hydrogel Spacer Injection versus Post-prostatectomy Radiotherapy for Prostate Cancer
Yang D, Yu J, An Y, Sprenkle P, Leapman M, Park H. P28 Rectal Radiation Dose Comparison Between Definitive Radiotherapy with Hydrogel Spacer Injection versus Post-prostatectomy Radiotherapy for Prostate Cancer. International Journal Of Radiation Oncology • Biology • Physics 2019, 103: e33. DOI: 10.1016/s0360-3016(19)30478-x.Peer-Reviewed Original Research
2018
Impact of Health Insurance Status on Prostate Cancer Treatment Modality Selection in the United States
Bledsoe T, Park H, Rutter C, Aneja S, Nguyen PL, Yu J. Impact of Health Insurance Status on Prostate Cancer Treatment Modality Selection in the United States. American Journal Of Clinical Oncology 2018, 41: 1062-1068. PMID: 29521648, DOI: 10.1097/coc.0000000000000423.Peer-Reviewed Original ResearchTreatment modality selectionInsurance statusTreatment modalitiesProstate cancerPrivate insuranceProstate cancer treatment modalitiesMultivariable logistic regression analysisInvasive surgeryModality selectionCancer-directed treatmentD'Amico risk classificationTreatment modality choiceNational Cancer DatabaseLocalized prostate cancerPatient insurance statusExternal beam radiotherapyLogistic regression analysisHealth insurance statusStrongest predictorMen ages 18Cancer treatment modalitiesClinical factorsMultivariable analysisActive surveillanceCancer DatabaseAssociation Between Prostate Magnetic Resonance Imaging and Observation for Low-risk Prostate Cancer
Leapman MS, Wang R, Park HS, Yu JB, Weinreb JC, Gross CP, Ma X. Association Between Prostate Magnetic Resonance Imaging and Observation for Low-risk Prostate Cancer. Urology 2018, 124: 98-106. PMID: 30107188, DOI: 10.1016/j.urology.2018.07.041.Peer-Reviewed Original ResearchConceptsLow-risk prostate cancerProstate magnetic resonance imagingMagnetic resonance imagingProstate cancerDefinitive treatmentPCa diagnosisEnd Results-Medicare databaseResonance imagingMultivariable logistic regression analysisPropensity scoreDiagnosis of PCaUse of MRIConditional logistic regression modelsLogistic regression analysisLogistic regression modelsInitial managementMultivariable analysisGreater oddsPatientsSocioeconomic statusDiagnosisHigher likelihoodRegression analysisDemographic factorsCancerMP53-08 USE OF PROSTATE MAGNETIC RESONANCE IMAGING AMONG MEDICARE BENEFICIARIES WITH LOW-RISK PROSTATE CANCER IS ASSOCIATED WITH A HIGHER LIKELIHOOD OF DEFINITIVE TREATMENT
Leapman M, Wang R, Park H, Yu J, Gross C, Ma X. MP53-08 USE OF PROSTATE MAGNETIC RESONANCE IMAGING AMONG MEDICARE BENEFICIARIES WITH LOW-RISK PROSTATE CANCER IS ASSOCIATED WITH A HIGHER LIKELIHOOD OF DEFINITIVE TREATMENT. Journal Of Urology 2018, 199: e707. DOI: 10.1016/j.juro.2018.02.1679.Peer-Reviewed Original ResearchNational trends in the management of patients with positive surgical margins at the time of radical prostatectomy.
Ghabili K, Nguyen K, Hsiang W, Syed J, Suarez-Sarmiento A, Shuch B, Park H, Yu J, Leapman M. National trends in the management of patients with positive surgical margins at the time of radical prostatectomy. Journal Of Clinical Oncology 2018, 36: 111-111. DOI: 10.1200/jco.2018.36.6_suppl.111.Peer-Reviewed Original ResearchAdjuvant radiation therapyAndrogen deprivation therapyPositive surgical marginsNational Cancer DatabaseAdjuvant therapyRadical prostatectomyRadiation therapyProstate cancerPathologic featuresSurgical marginsAddition of ADTAdjuvant androgen deprivation therapyStudy periodPre-treatment PSAPrimary definitive treatmentMajority of patientsManagement of patientsGleason grade groupCourse of managementOptimal management approachNon-academic facilitiesLogistic regression modelsBinary logistic regression modelAnalysis menDeprivation therapy
2016
The Association Between Evaluation at Academic Centers and the Likelihood of Expectant Management in Low-risk Prostate Cancer
Lester-Coll NH, Park HS, Rutter CE, Corso CD, Mancini BR, Yeboa DN, Kim SP, Gross CP, Yu JB. The Association Between Evaluation at Academic Centers and the Likelihood of Expectant Management in Low-risk Prostate Cancer. Urology 2016, 96: 128-135. PMID: 27392652, DOI: 10.1016/j.urology.2016.06.042.Peer-Reviewed Original ResearchConceptsLow-risk prostate cancerCancer center typeExpectant managementProstate cancerAcademic centersDefinitive treatmentNational Cancer Data BaseHierarchical mixed-effects logistic regression modelsMixed effects logistic regression modelsEffects logistic regression modelsLogistic regression modelsCommunity centersSurvival benefitActive surveillanceCenter typeRetrospective analysisLarge cohortTreatment selectionPertinent covariatesCancerInterfacility variationMenFacility typeFurther investigationRegression models
2015
Evaluation at Academic Centers Increases the Likelihood of Active Surveillance in Low-Risk Prostate Cancer
Lester-Coll N, Park H, Rutter C, Corso C, Mancini B, Yeboa D, Kim S, Gross C, Yu J. Evaluation at Academic Centers Increases the Likelihood of Active Surveillance in Low-Risk Prostate Cancer. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: s118. DOI: 10.1016/j.ijrobp.2015.07.281.Peer-Reviewed Original ResearchMinimally Invasive Surgery and External Beam Radiation Therapy Selection for Prostate Cancer Varies Significantly by Health Insurance Status
Bledsoe T, Park H, Rutter C, Aneja S, Yu J. Minimally Invasive Surgery and External Beam Radiation Therapy Selection for Prostate Cancer Varies Significantly by Health Insurance Status. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: e358-e359. DOI: 10.1016/j.ijrobp.2015.07.1461.Peer-Reviewed Original Research
2013
Statins and prostate cancer recurrence following radical prostatectomy or radiotherapy: a systematic review and meta-analysis
Park HS, Schoenfeld JD, Mailhot RB, Shive M, Hartman RI, Ogembo R, Mucci LA. Statins and prostate cancer recurrence following radical prostatectomy or radiotherapy: a systematic review and meta-analysis. Annals Of Oncology 2013, 24: 1427-1434. PMID: 23508824, PMCID: PMC3660083, DOI: 10.1093/annonc/mdt077.Peer-Reviewed Original ResearchConceptsRecurrence-free survivalPrimary treatment modalityLocalized prostate cancerEffect of statinsRadical prostatectomy patientsProstate cancer recurrenceHazard ratioProstatectomy patientsTreatment modalitiesRadical prostatectomyCancer recurrenceProstate cancerProstate cancer patientsOncologic outcomesDefinitive treatmentRT patientsCancer patientsEmbase databasesEligible studiesStatinsPatientsSystematic reviewRadiotherapyBeneficial effectsSystematic search