2021
Effect of prior thoracic radiotherapy on prognosis in relapsed small cell lung cancer patients treated with anlotinib: a subgroup analysis of the ALTER 1202 trial
Liu Y, Cheng Y, Li K, Shi J, Liu Y, Wu L, Han B, Chen G, He J, Wang J, Qin H, Li X, Hamaji M, Park HS. Effect of prior thoracic radiotherapy on prognosis in relapsed small cell lung cancer patients treated with anlotinib: a subgroup analysis of the ALTER 1202 trial. Translational Lung Cancer Research 2021, 10: 3793-3806. PMID: 34733629, PMCID: PMC8512470, DOI: 10.21037/tlcr-21-632.Peer-Reviewed Original ResearchDisease control rateProgression-free survivalObjective response rateSmall cell lung cancerOverall survivalThoracic radiotherapySubgroup analysisRT subgroupPlacebo-controlled phase 2 trialSmall cell lung cancer patientsCell lung cancer patientsPrevious thoracic radiotherapyPrior thoracic radiotherapyRelapsed SCLC patientsPhase 2 trialCell lung cancerLung cancer patientsOS benefitPFS benefitSCLC patientsPlacebo groupPlacebo armRT patientsCancer patientsControl rate
2020
Mutational Profile Evaluates Response and Survival to First‐Line Chemotherapy in Lung Cancer
He Y, Song L, Wang H, Chen P, Liu Y, Sun H, Li X, Dang S, Liu G, Liu X, Chen S, Zhang X, Hofman P, Uchino J, Park HS, Pacheco JM, Tabbò F, Xu M, Dai J, He K, Yang Y, Zhou C, Group W. Mutational Profile Evaluates Response and Survival to First‐Line Chemotherapy in Lung Cancer. Advanced Science 2020, 8: 2003263. PMID: 33643802, PMCID: PMC7887584, DOI: 10.1002/advs.202003263.Peer-Reviewed Original ResearchFirst-line chemotherapyLung cancer patientsLong-term survivalNSCLC patientsCancer patientsLung cancerTherapeutic responseProgression-free survivalMolecular signaturesWhole-exome sequencingLine chemotherapySCLC patientsFree survivalWorse survivalHigh TMBTherapeutic decisionsResults HistologyMolecular subtypesPatientsChemotherapyDifferent subtypesSubtypesLimited biomarkersTissue samplesSurvivalQuantifying Treatment Selection Bias Effects on Survival in National Database Studies: Findings from Low-Risk Prostate Cancer Patients
Miccio J, Talcott W, Jairam V, Park H, Yu J, Leapman M, King M, Nguyen P, Kann B. Quantifying Treatment Selection Bias Effects on Survival in National Database Studies: Findings from Low-Risk Prostate Cancer Patients. International Journal Of Radiation Oncology • Biology • Physics 2020, 108: e397. DOI: 10.1016/j.ijrobp.2020.07.2439.Peer-Reviewed Original ResearchEmergency Department Presentations Resulting in Percutaneous Endoscopic Gastrostomy Tube Placement Among Head and Neck Cancer Patients
Talcott W, Blakaj A, Jairam V, Park H. Emergency Department Presentations Resulting in Percutaneous Endoscopic Gastrostomy Tube Placement Among Head and Neck Cancer Patients. International Journal Of Radiation Oncology • Biology • Physics 2020, 108: e838-e839. DOI: 10.1016/j.ijrobp.2020.07.378.Peer-Reviewed Original ResearchQuantifying treatment selection bias effect on survival in comparative effectiveness research: findings from low-risk prostate cancer patients
Miccio JA, Talcott WJ, Jairam V, Park HS, Yu JB, Leapman MS, Johnson SB, King MT, Nguyen PL, Kann BH. Quantifying treatment selection bias effect on survival in comparative effectiveness research: findings from low-risk prostate cancer patients. Prostate Cancer And Prostatic Diseases 2020, 24: 414-422. PMID: 32989262, DOI: 10.1038/s41391-020-00291-3.Peer-Reviewed Original ResearchConceptsProstate cancer-specific survivalLow-risk prostate cancerExternal beam radiotherapyTreatment selection biasOverall survivalRadical prostatectomyProstate cancerOS differenceLow-risk prostate cancer patientsCancer-specific survivalEnd Results (SEER) databaseProstate cancer patientsClinical trial designEffectiveness researchComparative effectiveness researchPropensity-score matchingMethodsThe SurveillanceTreatment guidelinesResults databaseEntire cohortResultsA totalCancer patientsTreatment modalitiesNational registryPatient managementThe Association Between the Affordable Care Act and Insurance Status, Stage and Treatment in Patients with Testicular Cancer.
Hsiang W, Han X, Jemal A, Nguyen KA, Shuch B, Park H, Yu JB, Gross CP, Davidoff AJ, Leapman MS. The Association Between the Affordable Care Act and Insurance Status, Stage and Treatment in Patients with Testicular Cancer. Urology Practice 2020, 7: 252-258. PMID: 34017908, PMCID: PMC8130174, DOI: 10.1097/upj.0000000000000109.Peer-Reviewed Original ResearchGerm cell tumorsTesticular germ cell tumorsProportion of patientsAffordable Care ActNon-expansion statesNational Cancer Data BaseExpansion statusState Medicaid expansion statusTesticular cancer patientsAdvanced-stage cancerLate-stage diagnosisLow-income patientsHealth insuranceCare ActMedicaid expansion statesMedicaid expansion statusDisease stageCancer patientsInsurance statusTesticular cancerCell tumorsPost-ACAMedicaid coveragePatientsMedicaid expansionAuthor Correction: Suicide among cancer patients
Zaorsky NG, Zhang Y, Tuanquin L, Bluethmann SM, Park HS, Chinchilli VM. Author Correction: Suicide among cancer patients. Nature Communications 2020, 11: 718. PMID: 32005824, PMCID: PMC6994458, DOI: 10.1038/s41467-020-14506-7.Peer-Reviewed Original ResearchCancer patients
2019
Clinical Outcomes of Head and Neck Cancer Patients Who Undergo Resection, But Forgo Adjuvant Therapy
LOGANADANE G, KANN BH, PARK HS, JOHNSON SB, MEHRA S, JUDSON BL, BHATIA A, BELKACEMI Y, YARBROUGH WG, BURTNESS B, HUSAIN ZA. Clinical Outcomes of Head and Neck Cancer Patients Who Undergo Resection, But Forgo Adjuvant Therapy. Anticancer Research 2019, 39: 4885-4890. PMID: 31519591, DOI: 10.21873/anticanres.13674.Peer-Reviewed Original ResearchConceptsLocoregional recurrence-free survivalAdjuvant therapyNeck squamous cell carcinomaOutcomes of patientsRecurrence-free survivalSquamous cell carcinomaNeck cancer patientsHNSCC patientsClinical outcomesRecurrence rateCell carcinomaMean TTPCancer patientsPatientsTherapyResectionMonthsOutcomesHNSCCSurgeryCarcinomaHeadIncidenceProgressionEmergency department visits for prescription and synthetic opioid overdoses among patients with cancer.
Jairam V, Yang D, Yu J, Park H. Emergency department visits for prescription and synthetic opioid overdoses among patients with cancer. Journal Of Clinical Oncology 2019, 37: 6579-6579. DOI: 10.1200/jco.2019.37.15_suppl.6579.Peer-Reviewed Original ResearchED visitsOpioid overdoseEmergency departmentHigh riskOverdose ratesCervical cancerSynthetic opioidsUtilization Project Nationwide Emergency Department SampleNationwide Emergency Department SampleNon-cancer patientsEnd Results ProgramEmergency Department SampleIntrahepatic bile ductsPrimary cancer siteSynthetic opioid overdoseDiagnosis of cancerRespiratory intubationMetastatic diseaseHospital admissionOpioid dependencePrimary cancerBile ductResults ProgramCancer patientsCommon cancerSuicide among cancer patients
Zaorsky NG, Zhang Y, Tuanquin L, Bluethmann SM, Park HS, Chinchilli VM. Suicide among cancer patients. Nature Communications 2019, 10: 207. PMID: 30643135, PMCID: PMC6331593, DOI: 10.1038/s41467-018-08170-1.Peer-Reviewed Original ResearchConceptsStandardized mortality ratioCancer patientsHigh riskHigher standardized mortality ratiosColorectal cancer patientsEnd Results ProgramPopulation-based studyYears of agePredominant patientsLocalized diseasePerson yearsResults ProgramHodgkin's lymphomaTesticular tumorsMortality ratioRates of suicideGeneral populationPatientsCommitted suicideUnmarried malesLungSuicideRiskRepresentative dataLymphoma
2017
Post-operative radiotherapy is associated with improved survival in esophageal cancer with positive surgical margins
Gao SJ, Park HS, Corso CD, Rutter CE, Khan SA, Johung KL. Post-operative radiotherapy is associated with improved survival in esophageal cancer with positive surgical margins. Journal Of Gastrointestinal Oncology 2017, 8: 953-961. PMID: 29299354, PMCID: PMC5750177, DOI: 10.21037/jgo.2017.08.12.Peer-Reviewed Original ResearchPost-operative radiotherapyClinical stage INational Cancer Data BaseEarly-stage esophageal cancerOverall survivalPositive surgical marginsPositive marginsUpfront esophagectomyEsophageal cancerStage IImproved survivalSurgical marginsMultivariable Cox regression analysisImproved overall survivalReceipt of chemotherapyCox regression analysisMultivariable logistic regressionEsophageal cancer patientsLog-rank testAdjuvant chemotherapyOS benefitPostoperative chemotherapyPN0 diseaseMultivariable analysisCancer patientsSurvival Outcomes Among Human Papillomavirus-Associated Oropharyngeal Squamous Cell Cancer Patients Treated with Upfront Surgery Versus Definitive Chemoradiation Therapy
Kelly J, An Y, Park H, Yarbrough W, Burtness B, Husain Z. Survival Outcomes Among Human Papillomavirus-Associated Oropharyngeal Squamous Cell Cancer Patients Treated with Upfront Surgery Versus Definitive Chemoradiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2017, 99: s43-s44. DOI: 10.1016/j.ijrobp.2017.06.114.Peer-Reviewed Original ResearchStage I Lung SBRT Clinical Practice Patterns
Corso CD, Park HS, Moreno AC, Kim AW, Yu JB, Husain ZA, Decker RH. Stage I Lung SBRT Clinical Practice Patterns. American Journal Of Clinical Oncology 2017, 40: 358-361. PMID: 25503436, DOI: 10.1097/coc.0000000000000162.Peer-Reviewed Original ResearchConceptsStereotactic body radiation therapyNational Cancer DatabaseStage I non-small cell lung cancer patientsUse of SBRTNon-small cell lung cancer patientsCell lung cancer patientsStage I NSCLCMajority of patientsClinical practice patternsLung cancer patientsBody radiation therapyMedian BED10SBRT useDosing guidelinesRetrospective studyCancer patientsPrescription trendsCancer DatabasePractice patternsRadiation therapyPatientsDose prescriptionGyRegimensCommon prescriptionRole of Adjuvant Treatment in Esophageal Cancer With Incidental Pathologic Node Positivity
Gao SJ, Park HS, Corso CD, Rutter CE, Kim AW, Johung KL. Role of Adjuvant Treatment in Esophageal Cancer With Incidental Pathologic Node Positivity. The Annals Of Thoracic Surgery 2017, 104: 267-274. PMID: 28456393, DOI: 10.1016/j.athoracsur.2017.01.092.Peer-Reviewed Original ResearchConceptsMargin-positive patientsSurgical resectionEsophageal cancer patientsMargin-negative patientsAdjuvant treatmentChemoradiation therapyOverall survivalCarcinoma patientsCancer patientsMultivariable Cox regression analysisNational Cancer Data BaseSquamous cell carcinoma patientsPathologic nodal involvementPathologic node positivityConcurrent chemoradiation therapyAdjuvant chemoradiation therapyCell carcinoma patientsEsophageal carcinoma patientsCox regression analysisFurther prospective studiesOptimal adjuvant treatmentLog-rank testKaplan-Meier estimationAdjuvant chemotherapyN0 patients
2013
Statins and prostate cancer recurrence following radical prostatectomy or radiotherapy: a systematic review and meta-analysis
Park HS, Schoenfeld JD, Mailhot RB, Shive M, Hartman RI, Ogembo R, Mucci LA. Statins and prostate cancer recurrence following radical prostatectomy or radiotherapy: a systematic review and meta-analysis. Annals Of Oncology 2013, 24: 1427-1434. PMID: 23508824, PMCID: PMC3660083, DOI: 10.1093/annonc/mdt077.Peer-Reviewed Original ResearchConceptsRecurrence-free survivalPrimary treatment modalityLocalized prostate cancerEffect of statinsRadical prostatectomy patientsProstate cancer recurrenceHazard ratioProstatectomy patientsTreatment modalitiesRadical prostatectomyCancer recurrenceProstate cancerProstate cancer patientsOncologic outcomesDefinitive treatmentRT patientsCancer patientsEmbase databasesEligible studiesStatinsPatientsSystematic reviewRadiotherapyBeneficial effectsSystematic search
2011
Impact of Hospital Volume of Thoracoscopic Lobectomy on Primary Lung Cancer Outcomes
Park HS, Detterbeck FC, Boffa DJ, Kim AW. Impact of Hospital Volume of Thoracoscopic Lobectomy on Primary Lung Cancer Outcomes. The Annals Of Thoracic Surgery 2011, 93: 372-379. PMID: 21945225, DOI: 10.1016/j.athoracsur.2011.06.054.Peer-Reviewed Original ResearchConceptsPrimary lung cancer patientsLung cancer patientsShorter LOSMultivariable analysisMedian LOSHospital volumeIndependent predictorsPulmonary lobectomyOpen lobectomyCancer patientsVAT volumeUtilization Project Nationwide Inpatient Sample databaseVideo-assisted thoracoscopic surgery lobectomyHospital operative volumeShorter median LOSLung cancer outcomesPrimary lung cancerHigher hospital volumeShort-term outcomesThoracoscopic surgery lobectomyDiseases procedure codesTotal complicationsHospital lengthHospital morbidityVATS patients