Analyses of [18F]altanserin bolus injection PET data. I: Consideration of radiolabeled metabolites in baboons
Price J, Lopresti B, Mason N, Holt D, Huang Y, Mathis C. Analyses of [18F]altanserin bolus injection PET data. I: Consideration of radiolabeled metabolites in baboons. Synapse 2001, 41: 1-10. PMID: 11354008, DOI: 10.1002/syn.1054.Peer-Reviewed Original ResearchConceptsBolus injectionMajor radiometabolitePositron emission tomographySerotonin 2A receptor bindingBlood-brain barrier passageReceptor-rich regionsKetanserin administrationNonspecific radioactivityReceptor blockadeInput function methodEmission tomographyPET studiesPET dataReceptor bindingRadiometabolitesVivo kineticsInjectionBBBTissue componentsHuman brainBaboonsMetabolitesRadioactivityBlockadeAntagonistAnalyses of [18F]altanserin bolus injection PET data. II: Consideration of radiolabeled metabolites in humans
Price J, Lopresti B, Meltzer C, Smith G, Mason N, Huang Y, Holt D, Gunn R, Mathis C. Analyses of [18F]altanserin bolus injection PET data. II: Consideration of radiolabeled metabolites in humans. Synapse 2001, 41: 11-21. PMID: 11354009, DOI: 10.1002/syn.1055.Peer-Reviewed Original ResearchConceptsBlood-brain barrierPositron emission tomographyPrevious animal studiesAntagonist radiotracersPET dataBolus injectionAnimal studiesReference tissue methodEmission tomographyPET studiesArterial inputTissue measuresConstant radioactivityLogan analysisFurther studiesHigh-performance liquid chromatography analysisRadiometabolitesTissue methodLiquid chromatography analysisMetabolitesInjectionBolus