2017
Fibroblast growth factor receptor is a mechanistic link between visceral adiposity and cancer
Chakraborty D, Benham V, Bullard B, Kearney T, Hsia HC, Gibbon D, Demireva EY, Lunt SY, Bernard JJ. Fibroblast growth factor receptor is a mechanistic link between visceral adiposity and cancer. Oncogene 2017, 36: 6668-6679. PMID: 28783178, PMCID: PMC5709202, DOI: 10.1038/onc.2017.278.Peer-Reviewed Original ResearchConceptsAdipose tissueFibroblast growth factor-2 levelsGrowth factor-2 levelsFGFR-1Cancer prevention strategiesEpithelial cellsExcess adipose tissueTumor formationFactor 2 levelsVisceral adipose tissueNovel ex vivo systemSkin tumor formationObese human donorsNon-tumorigenic epithelial cellsSoft agarEx vivo systemGrowth factor receptorAdjuvant therapyEpithelial cell growthVisceral adiposityLevels of FGF2Obese individualsEpidemiological evidenceFibroblast growth factor receptorCancer risk
2006
Adenoviral-Mediated Expression and Local Deposition of Recombinant Tenascin-C Perturbs Cell-Dependent Matrix Contraction
Hsia HC, Schwarzbauer JE. Adenoviral-Mediated Expression and Local Deposition of Recombinant Tenascin-C Perturbs Cell-Dependent Matrix Contraction. Journal Of Surgical Research 2006, 136: 92-97. PMID: 16926030, DOI: 10.1016/j.jss.2006.05.030.Peer-Reviewed Original ResearchConceptsMammalian cellsLysophosphatidic acidRho GTPaseMatrix proteinsCell contractilityCell-matrix contactsCultured mammalian cellsRho GTPase pathwayLarge extracellular matrix glycoproteinProvisional matrixRecombinant adenovirus infectionMatrix contractionAdenoviral mediated expressionExtracellular matrix glycoproteinGTPase pathwayLarge proteinsEndogenous expressionThree-dimensional fibrinMatrix glycoproteinProteinGTPaseRecombinant adenovirus vectorControl cellsTenascin-C expressionRecombinant form
2004
Coregulation of Fibronectin Signaling and Matrix Contraction by Tenascin-C and Syndecan-4
Midwood KS, Valenick LV, Hsia HC, Schwarzbauer JE. Coregulation of Fibronectin Signaling and Matrix Contraction by Tenascin-C and Syndecan-4. Molecular Biology Of The Cell 2004, 15: 5670-5677. PMID: 15483051, PMCID: PMC532045, DOI: 10.1091/mbc.e04-08-0759.Peer-Reviewed Original ResearchConceptsSyndecan-4 functionsSyndecan-4Actin stress fiber formationFocal adhesion kinaseMatrix contractionStress fiber formationExtracellular matrix proteinsEfficient tissue repairEffects of tenascinProvisional matrixTissue repairHeparan sulfate proteoglycanAdhesion kinaseCell spreadingSignaling pathwaysMatrix proteinsFibronectin signalingThree-dimensional fibrinExtracellular matrixFiber formationSulfate proteoglycanCell interactionsFibroblast morphologyTenascinFibroblast response