2017
Fibroblast growth factor receptor is a mechanistic link between visceral adiposity and cancer
Chakraborty D, Benham V, Bullard B, Kearney T, Hsia HC, Gibbon D, Demireva EY, Lunt SY, Bernard JJ. Fibroblast growth factor receptor is a mechanistic link between visceral adiposity and cancer. Oncogene 2017, 36: 6668-6679. PMID: 28783178, PMCID: PMC5709202, DOI: 10.1038/onc.2017.278.Peer-Reviewed Original ResearchConceptsAdipose tissueFibroblast growth factor-2 levelsGrowth factor-2 levelsFGFR-1Cancer prevention strategiesEpithelial cellsExcess adipose tissueTumor formationFactor 2 levelsVisceral adipose tissueNovel ex vivo systemSkin tumor formationObese human donorsNon-tumorigenic epithelial cellsSoft agarEx vivo systemGrowth factor receptorAdjuvant therapyEpithelial cell growthVisceral adiposityLevels of FGF2Obese individualsEpidemiological evidenceFibroblast growth factor receptorCancer risk
2014
Reversible Modulation of Myofibroblast Differentiation in Adipose-Derived Mesenchymal Stem Cells
Desai VD, Hsia HC, Schwarzbauer JE. Reversible Modulation of Myofibroblast Differentiation in Adipose-Derived Mesenchymal Stem Cells. PLOS ONE 2014, 9: e86865. PMID: 24466271, PMCID: PMC3900664, DOI: 10.1371/journal.pone.0086865.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueBlotting, WesternCell DifferentiationCell MovementCells, CulturedExtracellular Matrix ProteinsFibroblast Growth Factor 2HumansMesenchymal Stem CellsMyofibroblastsReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSignal TransductionConceptsAdipose-derived mesenchymal stem cellsMesenchymal stem cellsExtracellular matrixERK/MAP kinaseMyofibroblastic phenotypeStem cellsRegulation of tenascinProtein type IActivation of Smad2Abundant extracellular matrixFocal adhesionsGrowth factorKinase downstreamHuman adipose-derived mesenchymal stem cellsCytoskeletal proteinsMAP kinaseStress fibersECM proteinsCell differentiationADSC differentiationDifferentiation processFibroblast-like cellsMyofibroblast differentiationNovel therapeutic strategiesRegenerative medicine